Regulation and Function of Basophil, Eosinophil and Mast Cell Responses -- Innate lymphoid cells: An Emerging Population in type 2 Inflammation -- Dendritic Cells and Type 2 Inflammation -- Th2 Cell Responses in Immunity and Inflammation Following Helminth Infection -- Regulatory T Cell Control of Type 2 Inflammation -- Developments in the Design of Anti-Helminth Vaccines -- Tissue Remodeling and Repair During Type 2 Inflammation -- Immune Response to Helminth Infections and as Treatment for Autoimmune Disorders -- Type 2 Immunity and Metabolism.

The type 2 immune response that develops during infectious disease has undergone major paradigm shifts in the last several years as new cell types and pathways have been identified.� It is now clear that the type 2 immune response, characterized by elevations in specific cytokines, including IL-4, IL-5 and IL-13, is associated with helminth infections in both humans and mice.� This response is complex and includes effector functions that mediate resistance, contributing to expulsion, and in some cases destruction, of the parasite.� But just as importantly, the type 2 immune response can also mediate tolerance mechanisms, which can mitigate tissue injury as these large multicellular parasites transit through vital organs.� The tolerance mechanisms include both tissue repair and immune regulatory effects. These latter aspects of the helminth-induced type 2 immune response are increasingly recognized as a potential resource that can be mined for the development of novel immunotherapies that may enhance wound healing, control of autoimmune and inflammatory diseases and regulation of metabolic homeostasis.� In this book, leading researchers in this exciting and dynamic field discuss the latest findings and emerging concepts, providing an intellectual framework that can be used as a basis for new discoveries and potentially new treatments for diseases associated with inflammation.