The Th2 Type Immune Response in Health and Disease : From Host Defense and Allergy to Metabolic Homeostasis and Beyond
The Th2 Type Immune Response in Health and Disease : From Host Defense and Allergy to Metabolic Homeostasis and Beyond
edited by William C Gause, David Artis
- 1st ed.
- 1 recurso en línea (XIV, 172 páginas) 23 ilustraciones en color
- McGraw-Hill's AccessMedicine .
Regulation and Function of Basophil, Eosinophil and Mast Cell Responses -- Innate lymphoid cells: An Emerging Population in type 2 Inflammation -- Dendritic Cells and Type 2 Inflammation -- Th2 Cell Responses in Immunity and Inflammation Following Helminth Infection -- Regulatory T Cell Control of Type 2 Inflammation -- Developments in the Design of Anti-Helminth Vaccines -- Tissue Remodeling and Repair During Type 2 Inflammation -- Immune Response to Helminth Infections and as Treatment for Autoimmune Disorders -- Type 2 Immunity and Metabolism.
The type 2 immune response that develops during infectious disease has undergone major paradigm shifts in the last several years as new cell types and pathways have been identified.� It is now clear that the type 2 immune response, characterized by elevations in specific cytokines, including IL-4, IL-5 and IL-13, is associated with helminth infections in both humans and mice.� This response is complex and includes effector functions that mediate resistance, contributing to expulsion, and in some cases destruction, of the parasite.� But just as importantly, the type 2 immune response can also mediate tolerance mechanisms, which can mitigate tissue injury as these large multicellular parasites transit through vital organs.� The tolerance mechanisms include both tissue repair and immune regulatory effects. These latter aspects of the helminth-induced type 2 immune response are increasingly recognized as a potential resource that can be mined for the development of novel immunotherapies that may enhance wound healing, control of autoimmune and inflammatory diseases and regulation of metabolic homeostasis.� In this book, leading researchers in this exciting and dynamic field discuss the latest findings and emerging concepts, providing an intellectual framework that can be used as a basis for new discoveries and potentially new treatments for diseases associated with inflammation.
9781493929115
Inmunología
QR185.8.T24 / T448 2016 EB
616.96
Regulation and Function of Basophil, Eosinophil and Mast Cell Responses -- Innate lymphoid cells: An Emerging Population in type 2 Inflammation -- Dendritic Cells and Type 2 Inflammation -- Th2 Cell Responses in Immunity and Inflammation Following Helminth Infection -- Regulatory T Cell Control of Type 2 Inflammation -- Developments in the Design of Anti-Helminth Vaccines -- Tissue Remodeling and Repair During Type 2 Inflammation -- Immune Response to Helminth Infections and as Treatment for Autoimmune Disorders -- Type 2 Immunity and Metabolism.
The type 2 immune response that develops during infectious disease has undergone major paradigm shifts in the last several years as new cell types and pathways have been identified.� It is now clear that the type 2 immune response, characterized by elevations in specific cytokines, including IL-4, IL-5 and IL-13, is associated with helminth infections in both humans and mice.� This response is complex and includes effector functions that mediate resistance, contributing to expulsion, and in some cases destruction, of the parasite.� But just as importantly, the type 2 immune response can also mediate tolerance mechanisms, which can mitigate tissue injury as these large multicellular parasites transit through vital organs.� The tolerance mechanisms include both tissue repair and immune regulatory effects. These latter aspects of the helminth-induced type 2 immune response are increasingly recognized as a potential resource that can be mined for the development of novel immunotherapies that may enhance wound healing, control of autoimmune and inflammatory diseases and regulation of metabolic homeostasis.� In this book, leading researchers in this exciting and dynamic field discuss the latest findings and emerging concepts, providing an intellectual framework that can be used as a basis for new discoveries and potentially new treatments for diseases associated with inflammation.
9781493929115
Inmunología
QR185.8.T24 / T448 2016 EB
616.96