Introduction to Purinergic Signalling in the Brain / Geoffrey Burnstock -- Adenosine Signaling in Glioma Cells / Stefania Ceruti and Maria P. Abbracchio -- Cross-Talk in Nucleotide Signaling in Glioma C6 Cells / Dorota Wypych and Jolanta Barańska -- Calcium Signaling in Glioma Cells -- The Role of Nucleotide Receptors / Dorota Wypych and Paweł Pomorski -- Purinergic Signaling in Glioma Progression / Elizandra Braganhol, Márcia Rosângela Wink, Guido Lenz and Ana Maria Oliveira Battastini -- Cytoskeleton and Nucleotide Signaling in Glioma C6 Cells / Wanda Kłopocka, Jarosław Korczyński and Paweł Pomorski -- Signaling Determinants of Glioma Cell Invasion / Aneta Kwiatkowska and Marc Symons -- Receptor Tyrosine Kinases: Principles and Functions in Glioma Invasion / Mitsutoshi Nakada, Daisuke Kita, Lei Teng, Ilya V. Pyko and Takuya Watanabe, et al. -- TGF Beta Signaling and Its Role in Glioma Pathogenesis / Bozena Kaminska, Marta Kocyk and Magdalena Kijewska -- STAT Signaling in Glioma Cells / Karolina Swiatek-Machado and Bozena Kaminska -- Cannabinoid Signaling in Glioma Cells / Aleksandra Ellert-Miklaszewska, Iwona Ciechomska and Bozena Kaminska

Gliomas, developing in the brain from the transformed glial cells, are a very special kind of tumors, extremely refractory to conventional treatments. Therefore, for the development of new antitumor strategies, a better understanding of molecular mechanisms responsible for their biology, growth and invasion is still needed. Glioma Signaling is a text reference on cellular signaling processes regulating gliomas physiology and invasiveness. The first half of the book is focused on the mechanism of nucleotide receptor activation by exogenous nucleotides. The remaining chapters deal with the formation of complex signaling cascades, including cytoplasmic transcription factors, induced by growth factors, cytokines and cannabinoids. The book provides a framework explaining how signal transduction elements may modulate glioma cytoskeleton structure, cytoplasmic calcium concentration, cellular growth, progression and invasion, as well as presents perspectives concerning potential targets for glioma therapy.