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SARS-CoV-2 Spike Protein Convergent Evolution : Impact of Virus Variants on Efficacy of COVID-19 Therapeutics and Vaccines / by Daniele Focosi

By: Focosi, Daniele, autor
Material type: materialTypeLabelE-bookSeries: (SpringerBriefs in Microbiology, 2191-5393); (Biomedical and Life Sciences (SpringerNature-11642)); (Biomedical and Life Sciences (R0) (SpringerNature-43708)).Publisher: Cham : Springer International Publishing, 2021Edition: First edition 2021.Description: 1 recurso en línea (XIII, 136 páginas) : 11 ilustraciones, 2 ilustraciones a color.ISBN: 9783030873240.Subject: COVID-19Online resources: Acceso a este recurso digital (usuarios Universidad Europea de Madrid)Digital Resources
Contents:
Chapter 1. Why the Spike protein is relevant for COVID19 therapeutics -- Chapter 2. SARS-CoV-2 variants -- Chapter 3. Conclusion.
Abstract: This book reviews the current knowledge of the globally circulating SARS-CoV-2 variants, highlights their distinct genetic characteristics and associated conformational changes in the viral spike protein, and profoundly discusses the mechanisms of convergent evolution that led to the rise of these mutated strains at different geographic regions during the Covid-19 pandemic. Furthermore, the book explores how these variants do and may impact the efficacy of established neutralizing antibody-based (nAb) vaccines and therapeutics by analysing latest in vivo and in vitro clinical data. Finally, the author discusses ways on how nAb Covid-19 treatment derived immune escape of SARS-CoV-2 could be minimized in the future.
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Holdings
Item type Current library Collection Call number Status Date due Barcode Item holds
LIBRO-E NO PRÉSTAMO LIBRO-E NO PRÉSTAMO Madrid Digital Acceso Electrónico (UEM) Ciencias de la Salud RA644 .C67 2021 EB (Browse shelf(Opens below)) Acceso electrónico eBook.18122410
Total holds: 0

Chapter 1. Why the Spike protein is relevant for COVID19 therapeutics -- Chapter 2. SARS-CoV-2 variants -- Chapter 3. Conclusion.

This book reviews the current knowledge of the globally circulating SARS-CoV-2 variants, highlights their distinct genetic characteristics and associated conformational changes in the viral spike protein, and profoundly discusses the mechanisms of convergent evolution that led to the rise of these mutated strains at different geographic regions during the Covid-19 pandemic. Furthermore, the book explores how these variants do and may impact the efficacy of established neutralizing antibody-based (nAb) vaccines and therapeutics by analysing latest in vivo and in vitro clinical data. Finally, the author discusses ways on how nAb Covid-19 treatment derived immune escape of SARS-CoV-2 could be minimized in the future.

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