SARS-CoV-2 Spike Protein Convergent Evolution : Impact of Virus Variants on Efficacy of COVID-19 Therapeutics and Vaccines
Focosi, Daniele
SARS-CoV-2 Spike Protein Convergent Evolution : Impact of Virus Variants on Efficacy of COVID-19 Therapeutics and Vaccines by Daniele Focosi - First edition 2021 - 1 recurso en línea (XIII, 136 páginas) 11 ilustraciones, 2 ilustraciones a color - SpringerBriefs in Microbiology 2191-5393 Biomedical and Life Sciences (SpringerNature-11642) Biomedical and Life Sciences (R0) (SpringerNature-43708) .
Chapter 1. Why the Spike protein is relevant for COVID19 therapeutics -- Chapter 2. SARS-CoV-2 variants -- Chapter 3. Conclusion.
This book reviews the current knowledge of the globally circulating SARS-CoV-2 variants, highlights their distinct genetic characteristics and associated conformational changes in the viral spike protein, and profoundly discusses the mechanisms of convergent evolution that led to the rise of these mutated strains at different geographic regions during the Covid-19 pandemic. Furthermore, the book explores how these variants do and may impact the efficacy of established neutralizing antibody-based (nAb) vaccines and therapeutics by analysing latest in vivo and in vitro clinical data. Finally, the author discusses ways on how nAb Covid-19 treatment derived immune escape of SARS-CoV-2 could be minimized in the future.
9783030873240
10.1007/978-3-030-87324-0 doi
COVID-19
RA644.C67 / 2021 EB
SARS-CoV-2 Spike Protein Convergent Evolution : Impact of Virus Variants on Efficacy of COVID-19 Therapeutics and Vaccines by Daniele Focosi - First edition 2021 - 1 recurso en línea (XIII, 136 páginas) 11 ilustraciones, 2 ilustraciones a color - SpringerBriefs in Microbiology 2191-5393 Biomedical and Life Sciences (SpringerNature-11642) Biomedical and Life Sciences (R0) (SpringerNature-43708) .
Chapter 1. Why the Spike protein is relevant for COVID19 therapeutics -- Chapter 2. SARS-CoV-2 variants -- Chapter 3. Conclusion.
This book reviews the current knowledge of the globally circulating SARS-CoV-2 variants, highlights their distinct genetic characteristics and associated conformational changes in the viral spike protein, and profoundly discusses the mechanisms of convergent evolution that led to the rise of these mutated strains at different geographic regions during the Covid-19 pandemic. Furthermore, the book explores how these variants do and may impact the efficacy of established neutralizing antibody-based (nAb) vaccines and therapeutics by analysing latest in vivo and in vitro clinical data. Finally, the author discusses ways on how nAb Covid-19 treatment derived immune escape of SARS-CoV-2 could be minimized in the future.
9783030873240
10.1007/978-3-030-87324-0 doi
COVID-19
RA644.C67 / 2021 EB