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Capillary Electrophoresis-Mass Spectrometry : Therapeutic Protein Characterization edited by James Q. Xia, Lichao Zhang - Cham Springer International Publishing 2016 - 1 recurso en línea (IX, 74 p.) 28 ilustraciones, 21 ilustraciones en color

Introduction to Capillary ElectrophoresisMass Spectrometry -- Coated Capillaries for CE-MS of Therapeutic Protein -- Intact Mass Analysis of Monoclonal Antibodies by Capillary Electrophoresis-Mass Spectrometry -- Separation and Characterization of Proteins and Peptides in Biological Fluids using CE-MS -- Host Cell Protein Analysis using CE-MS -- Antibody PTM Analysis using CE-MS -- Characterization of Intact Therapeutic Proteins and Protein Subunits using CE-MS Platform

This book covers the latest developments in capillary electrophoresis-mass spectrometry for the analysis of therapeutic proteins. The application of capillary electrophoresis-mass spectrometry (CE-MS) coupling technology in the analysis of recombinant therapeutic proteins is detailed thoroughly. Specific topics include recent developments in coupling capillary electrophoresis with mass spectrometry for the quality control of monoclonal antibody therapeutics, top-down analysis of monoclonal antibody using the CE-MS platform, and detection of host cell protein impurities. Comprehensive characterization of antibody-drug conjugates (ADCs) by coupling capillary electrophoresis with mass spectrometry is also covered. This is an ideal book for scientists in the life science and biopharmaceutical industry who are working on characterizing the PTMs of monoclonal antibodies, as well as graduate students and researchers in the separation science and biological mass spectrometry fields

ISBN: 9783319462400

Standard No.: 10.1007/978-3-319-46240-0 doi

Subjects--Topical Terms:
Espectrometría de masas
Proteínas
Microscopia

LC Class. No.: QP519.9.M3 / C375 2016 EB