Translational Research Methods for Diabetes, Obesity and Cardiometabolic Drug Development : A Focus on Early Phase Clinical Studies
Translational Research Methods for Diabetes, Obesity and Cardiometabolic Drug Development : A Focus on Early Phase Clinical Studies
edited by Andrew J. Krentz, Lutz Heinemann, Marcus Hompesch.
- London Springer 2015
- 1 recurso en línea (XII, 312 páginas) 76 ilustraciones, 39 ilustraciones en color
1. Review of physiology/pathophysiology -- 2. Methods for assessing insulin action in humans -- 3. Assessment of insulin secretion -- 4. Measurement of ectopic fat in liver and muscle using magnetic resonance spectroscopy -- 5. Isotopic tracers for theÂsurement of metabolic flux -- 6. Measuring food intake inÂnical drug development -- 7. Measurement of energy expenditure -- 8. Assessment of body composition -- 9.Âsessment of cardiovascular safety of new diabetes drugs.
This book aims to aid the selection of the most appropriate techniques for use in earlyÂse (1 and 2) clinicalÂdies of new drugs for diabetes, obesity, and related cardiometabolic disease. Clinical research methods for assessing theÂrmacokinetics and pharmacodynamics of new diabetes drugs, e.g. the euglycaemicÂmp technique,Âe become well-established in proof-of-mechanism studies; however, selection of the best techniques is by no means straightforward. This bookÂl the understanding of need newÂrmacotherapiesÂÂe 1 diabetes, type 2 diabetes, and obesity and the molecular targets of drugs currently in development.ÂEmergingÂhnologies including the omics disciplines considered togetherÂh practical and ethicalÂues ofÂly phase clinicalÂals in subjects with cardiometabolic disorders. Translational Research Methods for Diabetes, Obesity and Cardiometabolic Drug DevelopmentÂwill be of interest to biomedical scientists, pharmacologists, academics involved in metabolic research and clinicians practicing in these specialties.
9781447149200
10.1007/978-1-4471-4920-0 doi
Tecnología farmacéutica
Diabetes.
Farmacología
RM301.25 / 2015 EB
1. Review of physiology/pathophysiology -- 2. Methods for assessing insulin action in humans -- 3. Assessment of insulin secretion -- 4. Measurement of ectopic fat in liver and muscle using magnetic resonance spectroscopy -- 5. Isotopic tracers for theÂsurement of metabolic flux -- 6. Measuring food intake inÂnical drug development -- 7. Measurement of energy expenditure -- 8. Assessment of body composition -- 9.Âsessment of cardiovascular safety of new diabetes drugs.
This book aims to aid the selection of the most appropriate techniques for use in earlyÂse (1 and 2) clinicalÂdies of new drugs for diabetes, obesity, and related cardiometabolic disease. Clinical research methods for assessing theÂrmacokinetics and pharmacodynamics of new diabetes drugs, e.g. the euglycaemicÂmp technique,Âe become well-established in proof-of-mechanism studies; however, selection of the best techniques is by no means straightforward. This bookÂl the understanding of need newÂrmacotherapiesÂÂe 1 diabetes, type 2 diabetes, and obesity and the molecular targets of drugs currently in development.ÂEmergingÂhnologies including the omics disciplines considered togetherÂh practical and ethicalÂues ofÂly phase clinicalÂals in subjects with cardiometabolic disorders. Translational Research Methods for Diabetes, Obesity and Cardiometabolic Drug DevelopmentÂwill be of interest to biomedical scientists, pharmacologists, academics involved in metabolic research and clinicians practicing in these specialties.
9781447149200
10.1007/978-1-4471-4920-0 doi
Tecnología farmacéutica
Diabetes.
Farmacología
RM301.25 / 2015 EB