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008			180703b2006 xxua|||| |||| 00| 0 eng d
020			_a9780387271996
040			_aES-MaUEC _bspa _dES-MaUEC _cES-MaUEC
050		4	_aRM301.5 _b.B66 2006 EB
100			_984103 _aBonate, Peter L. _eautor
245	1	0	_aPharmacokinetic-Pharmacodynamic Modeling and Simulation _cPeter L. Bonate
264		4	_aBoston _bSpringer _c2006
300			_a1 recurso en línea (XII, 387 páginas)
336			_2rdacontent _aTexto (visual) _btxt
337			_2rdamedia _aelectrónico _bc
338			_2rdacarrier _arecurso electrónico _bcr
520		3	_aThis book presents both the art and science behind pharmacokinetic-pharmacodynamic modeling. Using a building-block approach, the author starts from linear and nonlinear models at the individual level and proceeds to develop more complex linear and nonlinear mixed effects models at the population level, with particular emphasis on showing the interrelationships between the various model types. The theory behind the methods are illustrated using real data drawn from the literature and from the author's own experiences in drug development. Data are analyzed using a variety of software, including SAS, WinNonlin, SAAM II, and NONMEM. A key component of the book is to show how models are accepted and rejected, ultimately leading to a useful and informative model that can be utilized using computer simulation to answer "what-if" questions.
988			_aEBOOK, EBSPRINGER
650		7	_aDrogas _xEfectos fisiológicos _2embne _9169030
830		0	_aMcGraw-Hill's AccessMedicine _9134597 _0Local
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/b138744 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
901			_ai9780387271996
907			_a.b12812274 _b10-10-17 _c01-10-14
942			_2lcc _cLE
945			_aEBOOK EB _g0 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11617299 _z01-07-17
998			_b07/2018 _dz _ea _feng _gxxu _h0