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007			cr cnu---unuuu
008			171202s2017 si o 000 0 eng d
020			_a9789811066740 _q(electronic bk.)
020			_a9811066744 _q(electronic bk.)
020			_z9789811066733
040			_aEBLCP _beng _cEBLCP _dOCLCO _dN$T _dGW5XE _dVT2 _dAZU _dUPM _dIOG _dOCLCF _dUAB _dMERER _dCASUM _dOCLCO _dES-MaUEC _bspa
050		4	_aQP624.5.M58 _b2017 EB
245	0	0	_aMitochondrial DNA and diseases _cHongzhi Sun, Xiangdong Wang, editors.
264		1	_aSingapore _bSpringer International Publishing _c2017
300			_a1 recurso en línea (233 páginas)
336			_aTexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_atext file _bPDF
490	0		_aAdvances in Experimental Medicine and Biology _vv.1038
500			_a
505	0		_aHow far can mitochondrial DNA drive the disease? -- Mitochondrial DNA in lung cancer -- Approach, application and bioethics of mtDNA sequencing in cancer -- Roles of mitochondrial DNA signaling in immune responses -- Mitochondrial DNA in Telocytes -- Roles of mitochondrial DNA in energy metabolism -- The role of base excision repair in maintaining mitochondrial DNA stability.- Is mitochondrial cell fragility a cell weakness? -- Mitochondrial DNA methylation and related disease -- Beyond deubiquitylation: USP30-mediated regulation of mitochondrial homeostasis -- Metabolic regulation in mitochondria and drug resistance.- Mitochondrial Lon Protease and Cancer -- Regulatory roles of mitochondrial ribosome in lung diseases and single cell biology.-Epithelial mitochondrial dysfunction in lung disease.
520	3		_aThe book describes molecular principles and mechanisms by which mitochondrial DNA (mtDNA) can drive the occurrence of diseases and the latest understanding of mtDNA biology. The book explores roles of mtDNA mutation and genetic changes in cancer, with a special focus on lung cancer, and the significance of approach, application, and bioethics of mtDNA sequencing.  Authors made a great effort to overview roles of mtDNA signaling pathways, base excision repair, methylation, USP30-mediated regulation, mitochondrial ribosome, autophagy pathways, or ROS-dependent signaling in the pathogenesis, diagnosis, prevention and treatment of diseases. It also demonstrates the importance of basic mitochondrial genetics and the relationship between mutations and disease phenotypes and ageing. This book covers not only the basic information of mtDNA, the relationship of mtDNA and disease, but also mtDNA in stem cell and mitochondria and metabolism etc. The book is written for biological and clinical students and researchers in the field of mtDNA-associated diseases.
588			_aDescription based upon print version of record.
988			_aEBOOK, EBSPRINGER_2017
650		7	_aADN mitocondrial _2embne _9670608
700	1		_aSun, Hongzhi.
700	1		_aWang, Xiangdong _986082
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=http://link.springer.com/10.1007/978-981-10-6674-0 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
998			_b02/2018 _dz _e- _zSI