000			03073cam a2200385Mi 4500
999			_c96734 _d96734 _x1
001			96734
003			ES-MaUEC
005			20230102112808.0
006			m d
007			cr cnu---unuuu
008			171202s2017 sz o 000 0 eng d
020			_a3319689290 _q(electronic bk.)
020			_a9783319689296 _q(electronic bk.)
020			_z3319689282
020			_z9783319689289
040			_aEBLCP _beng _erda _cEBLCP _dOCLCO _dYDX _dN$T _dGW5XE _dNOC _dUPM _dVT2 _dOCLCF _dUAB _dES-MaUEC _bspa
050		4	_aQR186 _b2017 EB
245	0	0	_aEmerging concepts targeting immune checkpoints in cancer and autoimmunity _cAkihiko Yoshimura, editor.
264		1	_aCham, Switzerland _bSpringer International Publishing _c2017
300			_a1 recurso en línea (268 páginas)
336			_aTexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
490	0		_aCurrent Topics in Microbiology and Immunology _vv.410
500			_aDescription based upon print version of record.
500			_a
505	0		_aRegulatory T cells: molecular and cellular basis for immunoregulation -- Overview of LAG-3- expressing, IL-10-producing regulatory T cells -- Regulatory Dendritic Cells -- Role of PD-1 in immunity and diseases -- CTLA-4, an essential immune-checkpoint for T cell activation -- Tim-3, Lag-3, and TIGIT -- SOCS1: regulator of T cells in autoimmunity and cancer -- Mining the complex family of protein tyrosine phosphatases for checkpoint regulators in immunity -- Immune regulation by ubiquitin tagging as checkpoint code -- MicroRNA in Immune Regulation.
520	3		_aThis volume reviews the current state of research on immune checkpoints and offers novel concepts. It discusses the two most important immune checkpoints: T lymphocyte-associated antigen-4 (CTLA-4) and programmed cell death-1 (PD-1). It shows that antagonistic antibodies against these two molecules are highly effective in the treatment of various cancers and that PD-1 and CTLA-4 have been linked to the suppression of T-cell receptor signaling and co-stimulatory molecules. Further, the volume examines other agents, a number of cells, receptors and signaling molecules, that are also involved in the regulation of T-cell activation and extends the concept of immune checkpoints to "molecules and cells that negatively regulate T-cell activation". Playing essential roles in immune homeostasis, they could offer new targets for cancer immunotherapy, and for the therapy of autoimmune diseases. Written by internationally respected scientists, this book will appeal to basic scientists, clinicians, drug development researchers, and advanced students alike.
988			_aEBOOK, EBSPRINGER_2017
650		7	_aCáncer _2embne _9139308
700	1		_aYoshimura, Akihiko.
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=http://link.springer.com/10.1007/978-3-319-68929-6 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
998			_b02/2018 _dz _e- _zSI