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020 _a9789811065835
_q(electronic bk.)
020 _a9811065837
_q(electronic bk.)
020 _z9789811065828
_q(hardcover : alk. paper)
020 _z9811065829
_q(hardcover : alk. paper)
040 _aEBLCP
_beng
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050 4 _aQP609.P76
_b2017 EB
245 0 0 _aDJ-1/PARK7 protein :
_bParkinson's disease, cancer and oxidative stress-induced diseases
_cHiroyoshi Ariga, Sanae M.M. Iguchi-Ariga, editors.
264 1 _aSingapore
_bSpringer International Publishing
_c2017
300 _a1 recurso en línea (224 páginas)
336 _aTexto
_btxt
_2rdacontent
337 _aelectrónico
_bc
_2rdamedia
338 _arecurso electrónico
_bcr
_2rdacarrier
347 _atext file
_bPDF
490 0 _aAdvances in experimental medicine and biology
_x2214-8019
_vvolume 1037
500 _a
504 _aIncluye referencias bibliográficas
505 0 _aIntroduction/overview -- Structural biology of the DJ-1 superfamily -- Expression of DJ-1 in patients with neurodegenerative diseases -- DJ-1 as an oncogene and its clinical significance -- Role of DJ-1 in fertilization -- Anti-oxidative stress function of DJ-1 -- Transcriptional regulation of DJ-1 -- Regulation of signal transduction by DJ-1 -- Protein repair by DJ-1 from glycation by glyoxal and methylglyoxal -- DJ-1 as a biomarker of Parkinson's disease -- Roles of DJ-1 in diabetes mellitus -- Therapeutic activities of DJ-1 and its binding compounds against neurodegenerative diseases -- DJ-1 as an oncogene and promising target for cancer chemotherapy.
520 3 _aThis book reviews the functions and roles of DJ-1 in various oxidative stress-related diseases and applications of DJ-1 and its binding compounds to the diseases. The DJ-1 gene was first found to be a novel oncogene in 1997 and later, in 2003, also found to be a causative gene for a familial form of Parkinson's disease (PD), park7. The DJ-1 gene is therefore the first gene discovered that is known to cause cancer and neurodenegerative diseases, including PD. The research field has expanded as the research has developed. Thus this volume begins with a general introduction of DJ-1, and explains the history and research development to understand the following chapters. Those chapters present the roles of DJ-1 in various oxidative stress-related diseases such as neurodegenerative diseases, as well as cancer, diabetes, and fertility. Moreover, several chapters present evidence that DJ-1 is useful for therapeutic strategies against these diseases. The reader will discover that DJ-1 is a promising protein both for basic cell biology and for the mechanism and therapy for oxidative stress-related diseases. .
588 _aDescription based on online resource; title from electronic title page (ProQuest Ebook Library, viewed January 9, 2018).
988 _aEBOOK, EBSPRINGER_2017
650 7 _aSistema nervioso
_2embne
_9138462
700 1 _aAriga, Hiroyoshi,
_eeditor literario
700 1 _aIguchi-Ariga, Sanae M. M.,
_eeditor literario
856 4 0 _uhttps://go.openathens.net/redirector/universidadeuropea.es?url=http://link.springer.com/10.1007/978-981-10-6583-5
_zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942 _2lcc
_cLE
998 _b02/2018
_dz
_e-
_zSI