000			04686cam a2200397Ia 4500
999			_c96714 _d96714 _x1
001			96714
003			ES-MaUEC
005			20230102112807.0
006			m o d
007			cr cnu---unuuu
008			171125s2017 si ob 000 0 eng d
020			_a9789811061417 _q(electronic bk.)
020			_a9811061416 _q(electronic bk.)
020			_z9789811061400
040			_aEBLCP _beng _epn _cEBLCP _dN$T _dGW5XE _dN$T _dVT2 _dOCLCQ _dAZU _dUPM _dIOG _dUAB _dMERER _dES-MaUEC _bspa
050		4	_aQP609.P78 _b2017 EB
245	0	0	_aPathophysiological aspects of proteases _cSajal Chakraborti, Naranjan S. Dhalla, editors.
264		1	_aSingapore _bSpringer International Publishing _c2017
300			_a1 recurso en línea (667 páginas)
336			_aTexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_atext file _bPDF
500			_a
504			_aIncluye referencias bibliográficas
505	0		_aProtease mediated viral infection -- Role of proteases in cancer pathology especially in breast cancer, as well as role of proteases as posible targets for drug development for cancer -- The multifunctional post-prolinedipeptidyl peptidase, DPP9, in EGF signaling, immunity and cancer biology -- Translating the knowledge of functional dynamics towards designing inhibitors of BACE1, a key aspartate protease in Alzheimer's disease -- Cysteine Dependent Aspartate Specific Proteases in Coronary Artery Disease -- Matrix metalloproteases: Potential role in Type 2 Diabetic Nephropathy -- Matrix-metalloproteinases in Breast Carcinoma, Immunohistology and Prognosis -- Matrix metalloproteinases in parasitic infections -- Role of proteases in cancer metastasis -- Proteolytic activation of kinase growth factors in the pathophysiology of cancer -- Involvement of m-Calpain in Colorectal Adenocarcinomas -- Proteases in Cancer: Potential Therapeutic Targets -- MMPs in Oral Squamous Cell Carcinoma -- Matrix metalloproteinase silencing: a therapeutic approach to treat cardiovascular pathology -- Proteases and Breast cancer -- Matrix metalloproteinases (MMPs) in cancer initiation and progression -- Neutrophil Serine protease in health and disease -- Proteases in disease pathology -- PAR1 mediated apoptosis and tumor regression of breast cancer cells by V. cholerae hemagglutinin protease -- Protein-protease interactions : an overview of the process from an 'in silico' perspective -- The functional relevance of Deubiquitinases in life and disease -- Physiological and pathological functions of mitochondrial proteases -- Proteases of parasitic helminths: their metabolic role in establishment of infection in the host -- Cysteine proteases of parasitic helminths -- Targeting proteases in urine for bladder cancer diagnosis.
520	3		_aThis book provides a comprehensive overview of the multifaceted field of protease in the cellular environment and focuses on the recently elucidated functions of complex proteolytic systems in physiology and pathophysiology. Given the breadth and depth of information covered in the respective contributions, the book will be immensely useful for researchers working to identify targets for drug development. Multidisciplinary in scope, the book bridges the gap between fundamental and translational research, with applications in the biomedical and pharmaceutical industry, making it a thought-provoking read for basic and applied scientists engaged in biomedical research.   Proteases represent one of the largest and most diverse families of enzymes known, and we now know that they are involved in every aspect of a given organism's life functions. Under physiological conditions, proteases are regulated by their endogenous inhibitors. However, when the activity of proteases is not correctly regulated, disease processes such as tumour progression, vascular remodelling, atherosclerotic plaque progression, ulcer, rheumatoid arthritis, Alzheimer's disease and inflammation can result. Many infective microorganisms require proteases for replication or use them as virulence factors, which has facilitated the development of protease-targeted therapies for a variety of parasitic diseases.
588	0		_aVersión impresa
988			_aEBOOK, EBSPRINGER_2017
650		7	_2embne _9144712 _aFisiopatología
700	1		_aChakraborti, Sajal. _984935
700	1		_aDhalla, Naranjan S. _984616
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=http://link.springer.com/10.1007/978-981-10-6141-7 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
998			_b02/2018 _dz _e- _zSI