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020 _a3319583387
_q(electronic bk.)
020 _a9783319583389
_q(electronic bk.)
020 _z9783319583372
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050 4 _aQP552.C48
_b2017 EB
245 0 0 _aChromogranins :
_bfrom cell biology to physiology and biomedicine
_cTommaso Angelone, Maria Carmela Cerra, Bruno Tota, editors.
264 1 _aCham, Switzerland
_bSpringer International Publishing
_c2017
300 _a1 recurso en línea (271 páginas)
336 _aTexto
_btxt
_2rdacontent
337 _aelectrónico
_bc
_2rdamedia
338 _arecurso electrónico
_bcr
_2rdacarrier
347 _atext file
_bPDF
490 0 _aUNIPA Springer Series
500 _a""2 Occurrence of Chromogranin A in Circulation""
500 _a
505 0 _a""Contents""; ""Contributors""; ""History and Perspectives""; ""1 History""; ""1.1 The First Hundred Years of the Chromaffin Cells""; ""1.2 The First Decade of the Chromaffin Granules""; ""1.3 The First Thirty Five Years of the Granins""; ""1.3.1 Glucose Homeostasis, Pancreastatin and the Prohormone Concept""; ""1.3.2 Calcium Homeostasis and the N-Terminus of CgA""; ""1.4 The Granins and their Derived Peptides""; ""1.4.1 The Antimicrobial Peptides and Innate Immunity""; ""1.5 Functional and Clinical Aspects""
505 8 _a""1.5.1 Vasostatins, Vasodilations, the Vascular Endothelium and Angiogenesis""""1.5.2 Vasostatins, Catestatin and Serpinin; Myocardial Contractility and Protection against Ischemia-Induced Injury""; ""1.5.3 Angiogenesis, Cell Adhesion and Tumor Progression""; ""1.5.4 A Physiological Role for the Circulating CgA""; ""1.5.5 Circulating CgA as a Marker for Inflammatory Diseases""; ""1.6 Putative Receptors for CgA and CgA-Derived Peptides""; ""2 Conclusions""; ""3 Perspectives""; ""References""
505 8 _a""2 I/ The Twenty-First Century, the Advent of Chromogranins as Critical Regulators of Secretory Granule Biogenesis""""3 II/ Hormone Aggregation as the First Function Assigned to Chromogranins""; ""4 III/ Hormone Sorting through Interaction of Chromogranins with the TGN Membrane""; ""5 IV/ Are Chromogranins Linked to Hypersecretory Endocrine Pathologies?""; ""6 Concluding Remarks""; ""References""; ""Involvement of Chromogranin A and Its Derived Peptides to Fight Infections""; ""1 Innate Immunity and Antimicrobial Peptides""
505 8 _a""8.2 Sorting and Release of Secretory Proteins""""8.3 Precursor of the Neuropeptide/Cytokine Secretoneurin""; ""8.3.1 Angiogenesis and Vasculogenesis""; ""8.3.2 Wound Healing""; ""8.3.3 Effects of SN on Cerebral Ischemia""; ""8.3.4 Effects of SN on Cardiomyocytes""; ""8.3.5 Effects of SN Gene Therapy on Animal Models of High Vascular Risk""; ""References""; ""Chromogranins as Molecular Coordinators at the Crossroads between Hormone Aggregation and Secretory Granule Biogenesis""; ""1 Introduction""
505 8 _a""Secretogranin II: Novel Insights into Expression and Function of the Precursor of the Neuropeptide Secretoneurin""""1 Introduction""; ""2 Structure & Posttranslational Modifications of Secretogranin II""; ""3 Subcellular Localization""; ""4 Tissue Expression and Secretion from Cells""; ""5 Phylogenetic Conservation of Secretogranin II""; ""6 Gene Organisation and Gene Regulation""; ""7 Biomarker and Disease""; ""7.1 Tumors""; ""7.2 CNS Diseases""; ""7.3 Heart Failure""; ""8 Physiologic Function of Secretogranin II""; ""8.1 Biogenesis of Secretory Granules""
520 3 _aThe volume is designed to provide an integrated overview of the results from the last fifteen years of research on Chromogranins in relation to cell biology, physiology and biomedicine. The different chapters highlight novel activities of these proteins, including their role in granule biogenesis, hormone co-storage, stimulus-processing-secretion coupling, autonomic sympathetic/parasympathetic balance, immune and cardiocirculatory function, and the response to stress. Biomedical aspects are also illustrated with focus on the prognostic and diagnostic significance of Chromogranin in the presence of tumors, cardiovascular diseases and inflammatory conditions. The volume is of interest for laboratory and clinical scientists, PhD and Post-doc students that will be inspired to go deep inside the molecular, biochemical, physiological, pharmacological and clinical aspects of these fascinating multifaceted proteins.
588 0 _aVersión impresa
988 _aEBOOK, EBSPRINGER_2017
650 7 _aProteínas
_2embne
_9139861
700 1 _aAngelone, Tommaso.
700 1 _aCerra, Maria Carmela.
700 1 _aTota, Bruno.
856 4 0 _uhttps://go.openathens.net/redirector/universidadeuropea.es?url=http://link.springer.com/10.1007/978-3-319-58338-9
_zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942 _2lcc
_cLE
998 _b02/2018
_dz
_e-
_zSI