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020 _a3319561065
_q(electronic bk.)
020 _a9783319561066
_q(electronic bk.)
020 _z3319561049
020 _z9783319561042
040 _aN$T
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050 4 _aRC683.8
_b2017 EB
245 0 0 _aCardiac regeneration
_cMasaki Ieda, Wolfram-Hubertus Zimmermann, editors.
264 1 _aCham, Switzerland
_bSpringer International Publishing
_c2017
300 _a1 recurso en línea
336 _aTexto
_btxt
_2rdacontent
337 _aelectrónico
_bc
_2rdamedia
338 _arecurso electrónico
_bcr
_2rdacarrier
347 _atext file
_bPDF
490 0 _aCardiac and vascular biology
500 _a
504 _aIncluye referencias bibliográficas
505 0 _a""Preface""; ""Contents""; ""1: Past and Future of Cell-Based Heart Repair""; ""1.1 Introduction""; ""1.2 Cell Therapy for Cardiac Repair""; ""1.2.1 Skeletal Myoblasts""; ""1.2.2 Bone Marrow-Derived Stem Cells""; ""1.2.3 Endothelial Progenitors""; ""1.2.4 Mesenchymal Stem Cells""; ""1.2.5 Endogenous Cardiac Stem Cells""; ""1.2.5.1 C-kit + Cardiac Progenitors""; ""1.2.5.2 Cardiosphere and Cardiosphere-Derived Cells""; ""1.2.5.3 Side Population Cells""; ""1.2.5.4 Sca1+ Cardiac Progenitors""; ""1.2.5.5 Islet1+ Cardiac Progenitors""; ""1.2.5.6 Epicardial Progenitors""
505 8 _a""1.2.6 ES-Derived Cardiomyocytes""""1.2.7 Induced Pluripotent Stem Cells and Reprogramming""; ""1.2.7.1 iPSCs""; ""1.2.7.2 Direct Reprogramming into Cardiomyocytes""; ""1.3 Future of Cell Therapy""; ""References""; ""2: Progenitor Cells from the Adult Heart""; ""2.1 Phenotype and Characteristics of eCSCs""; ""2.1.1 c-kitpos Stem and Progenitor Cells""; ""2.1.2 Sca-1pos and Side Population Progenitor Cells""; ""2.2 Cardiac Differentiation Potential of eCSCs""; ""2.3 The Controversy""; ""2.4 Origin of eCSCs""; ""2.5 Impact of Ageing and Senescence on eCSCs""
505 8 _a""2.6 Therapeutic Targets to Activate eCSCs and Reverse the Senescent, Dysfunctional eCSC Phenotype""""References""; ""3: Epicardial Progenitors in the Embryonic and Adult Heart""; ""3.1 Epicardial Development Across Species""; ""3.2 EPDC Derivatives and Epicardial Heterogeneity""; ""3.2.1 Epicardium Contribution to Coronary Endothelial Cells""; ""3.2.2 Epicardial Contribution to Cardiomyocytes""; ""3.2.3 Epicardial Contribution to Fat Cells""; ""3.3 The Epicardium as a Signaling Center in the Developing Heart""
505 8 _a""3.3.1 Epicardial Signals Promoting Cardiomyocyte Proliferation""""3.3.2 Epicardial Signals Directing Coronary Angiogenesis""; ""3.3.3 Other Epicardial Signals Contributing to Heart Development""; ""3.4 Adult Epicardium""; ""3.4.1 Physiological Role of the Epicardium in Homeostatic Conditions""; ""3.4.2 The Epicardium to Regenerate the Adult Heart""; ""3.5 Human Epicardium""; ""References""; ""4: Generation and Application of Human Pluripotent Stem Cell-Derived Cardiomyocytes""; ""4.1 Introduction""; ""4.2 Applications""; ""4.2.1 Regenerative Medicine""
505 8 _a""4.2.2 Biological Pacemaker Development""""4.2.3 Understanding of Human Cardiac Development""; ""4.2.4 Disease Modeling""; ""4.2.5 Drug Discovery, Pharmacogenomics, and Cardiotoxicity Screening""; ""4.3 Cardiomyogenesis during Mammalian Heart Development""; ""4.4 Control of the Pluripotent State""; ""4.5 Human Pluripotent Growth Media""; ""4.6 Priming for Cardiac Differentiation""; ""4.7 Maintenance of hiPSC-Derived Mesodermal Intermediates and Cardiac Progenitor Cells""; ""4.8 Directed Cardiac Differentiation of Human Pluripotent Stem Cells""
520 3 _aThis Volume of the series Cardiac and Vascular Biology offers a comprehensive and exciting, state-of-the-art work on the current options and potentials of cardiac regeneration and repair. Several techniques and approaches have been developed for heart failure repair: direct injection of cells, programming of scar tissue into functional myocardium, and tissue-engineered heart muscle support. The book introduces the rationale for these different approaches in cell-based heart regeneration and discusses the most important considerations for clinical translation. Expert authors discuss when, why, and how heart muscle can be salvaged. The book represents a valuable resource for stem cell researchers, cardiologists, bioengineers, and biomedical scientists studying cardiac function and regeneration.
988 _aEBOOK, asignarmaterias, EBSPRINGER_2017
650 7 _9138557
_aCardiología
_2fast
_0(OCoLC)fst00847121
_0
700 1 _aIeda, Masaki,
_eeditor literario
700 1 _aZimmermann, Wolfram-Hubertus,
_eeditor literario
856 4 0 _uhttps://go.openathens.net/redirector/universidadeuropea.es?url=http://link.springer.com/10.1007/978-3-319-56106-6
_zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942 _2lcc
_cLE
998 _b02/2018
_dz
_e-
_zSI