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020 _a3319645269
_q(electronic bk.)
020 _a9783319645247
020 _a9783319645261
_q(electronic bk.)
020 _z9783319645247
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066 _c(S
050 4 _aQR186.8.M2
_b2017 EB
245 0 0 _aIgM and its receptors and binding proteins
_cHiromi Kubagawa, Peter D. Burrows, editors.
264 1 _aCham, Switzerland
_bSpringer International Publishing
_c2017
264 4 _c2017
300 _a1 recurso en línea
_bilustraciones
336 _aTexto
_btxt
_2rdacontent
337 _aelectrónico
_bc
_2rdamedia
338 _arecurso electrónico
_bcr
_2rdacarrier
347 _atext file
_bPDF
490 0 _aCurrent topics in microbiology and immunology
_vv. 408
500 _a
_bSpringer Biomedical and Life Sciences eBooks 2017 English+International
504 _aIncluye referencias bibliográficas
505 0 _6880-01
_a""Preface""; ""References""; ""Contents""; ""22 The Appearance and Diversification of Receptors for IgM During Vertebrate Evolution""; ""Abstract""; ""1 The Adaptive Immune System of Vertebrates""; ""2 The Appearance of Receptors Interacting with the Constant Domain of Igs""; ""3 The Polymeric Ig Receptorâ#x80;#x94;PIGR""; ""4 The FcαµR""; ""5 The FcµR""; ""6 Concluding Remarks""; ""Acknowledgements""; ""References""; ""23 Authentic IgM Fc Receptor (FcμR)""; ""Abstract""; ""1 Introduction""; ""2 Lymphocyte-Restricted Expression of FcµR""; ""3 Unique Ligand-Binding Activity""
505 8 _a""1 Introduction""""1.1 IgG-Mediated Feedback Suppression""; ""1.2 IgG-Mediated Feedback Enhancement""; ""1.3 IgE-Mediated Feedback Enhancement""; ""1.4 IgM-Mediated Feedback Enhancement""; ""2 Basic Parameters of IgM-Mediated Enhancement""; ""2.1 Antigens""; ""2.2 The IgM Molecule and Mode of Administration""; ""2.3 Primary Antibody Responses""; ""2.4 Priming for Memory Responses""; ""2.5 Avidity of the Enhanced Response""; ""2.6 Germinal Center Responses""; ""2.7 Specificity of the Enhanced Antibody Response""; ""2.8 T Cells and IgM-Mediated Enhancement""
505 8 _a""3 Complement in Antibody Responses to Uncomplexed Antigen""""4 Complement in Antibody Responses to IgM-Antigen Complexes""; ""4.1 Complement Activation by IgM""; ""4.2 Complement Receptors 1 and 2, CR1/2, in Antibody Responses to IgM-Antigen Complexes""; ""4.3 Cμ13 Knock-in Mice with a Point Mutation in the IgM Heavy Chain Abolishing C1q-Binding""; ""4.4 FcμR (Toso/Faim3) and IgM-Mediated Enhancement""; ""4.5 Other IgM-Binding Receptors and IgM-Mediated Enhancement""; ""4.6 Specific IgM from Wildtype but not Cμ13 Mice, Causes Rapid Deposition of C3 on SRBC in Vivo""
505 8 _a""3.1 Fcµ-Specificity, Ligand-Binding Avidity, and Glycosylation""""3.2 Cis Engagement""; ""3.3 Modulatory Effect of FcµR by Cis Engagement""; ""3.4 Key Residues in the Transmembrane and Cytoplasmic Tail for FcµR Function""; ""4 FcµR Deficiency in Mice""; ""5 Epilogue""; ""Acknowledgements""; ""References""; ""40 FCRLAâ#x80;#x94;A Resident Endoplasmic Reticulum Protein that Associates with Multiple Immunoglobulin Isotypes in B Lineage Cells""; ""Abstract""; ""1 Introductionâ#x80;#x94;Fc Receptors and Their Relatives""; ""2 The Identification of FCRLA and FCRLB""; ""3 The FCRLA Genome Landscape""
505 8 _a""4 Features of the FCRLA Protein""""5 FCRLAâ#x80;#x94;Phylogeny and Disease Association""; ""6 FCRLAâ#x80;#x94;Expression Pattern and Regulation""; ""7 FCRLA is a Soluble Resident ER Protein""; ""8 FCRLA is Retained in the ER via its N-terminal Disordered Domain""; ""9 FCRLA Associates with Multiple Ig Isotypes in the ER""; ""10 TRIM21â#x80;#x94;One Other Intracellular Fc Receptor that Binds Multiple Ig Isotypes""; ""11 FCRLA Functionâ#x80;#x94;Facts and Speculations""; ""11.1 Facts""; ""11.2 Speculations""; ""Acknowledgements""; ""References""; ""24 Specific IgM and Regulation of Antibody Responses""; ""Abstract""
650 7 _aInmunoglobulinas
_2embne
_0(OCoLC)fst00967957
_0
_9143641
700 1 _aBurrows, Peter D.,
_eeditor literario
700 1 _aKubagawa, Hiromi,
_eeditor literario
856 4 0 _uhttps://go.openathens.net/redirector/universidadeuropea.es?url=http://link.springer.com/10.1007/978-3-319-64526-1
_zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
880 _6520-00/(S
_aThis volume reviews the current state of research on the IgM antibody and its multiple receptors and binding proteins. Interactions of the IgM ligands with these molecules are important for protection against infections as a first line of defense, as well as for regulation of immune responses to pathogens and self-antigens. The book includes up-to-date information on: (i) the phylogeny of three IgM-binding receptors [polymeric Ig receptor (pIgR), Fc receptor for both IgA and IgM (Fcα/µR), and Fc receptor for IgM only (FcµR)]; (ii) the lymphocyte-restricted distribution and unique ligand-binding activity of FcµR; (iii) the definition and potential function of Fc receptor-like molecule A (FCRLA) as a resident endoplasmic reticulum protein that binds IgM, but also IgG and IgA; (iv) IgM antibody-mediated enhancement of humoral immune responses, highlighting the importance of complement and its receptors, (v) the numerous important roles of IgM natural antibodies in regulation of inflammation. It is an invaluable resource for researchers and clinicians alike.
880 0 _6505-01/(S
_aThe appearance and diversification of receptors for IgM during vertebrate evolution. -- Authentic IgM Fc Receptor (FcμR) -- FCRLA -- A resident endoplasmic reticulum protein that associates with multiple immunoglobulin isotypes in B lineage cells -- Specific IgM and regulation of antibody responses -- Role of Natural IgM autoantibodies (IgM- NAA) and IgM anti-leucocyte antibodies (IgM-ALA) in regulating inflammation.
988 _aEBOOK, asignarmaterias, EBSPRINGER_2017
998 _b02/2018
_dz
_e-
_zSI
999 _c96634
_d96634
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