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050 4 _aTP248.F6
_b2017 EB
100 1 _aHe, Rongqiao,
_eautor
245 1 0 _aFormaldehyde and cognition
_cRongqiao He.
264 1 _aDordrecht, the Netherlands
_bSpringer International Publishing
_c2017
264 4 _c2017
300 _a1 recurso en línea
336 _aTexto
_btxt
_2rdacontent
337 _aelectrónico
_bc
_2rdamedia
338 _arecurso electrónico
_bcr
_2rdacarrier
347 _atext file
_bPDF
500 _a
504 _aIncluye referencias bibliográficas e índice
505 0 _a""Preface""; ""References""; ""Contents""; ""Chapter 1: Formaldehyde from Environment""; ""1 Introduction""; ""2 Formaldehyde Sources""; ""2.1 Natural Sources of Formaldehyde""; ""2.2 Anthropogenic Sources of Formaldehyde""; ""3 Formaldehyde Inhalation Exposure""; ""3.1 Indoor Formaldehyde Inhalation Exposure""; ""3.1.1 Indoor Residential Formaldehyde Exposure""; ""3.1.2 Indoor Office Exposure""; ""3.1.3 Indoor Public Exposure""; ""3.1.4 Indoor Occupational Exposure""; ""3.2 Outdoor Air Exposure""; ""4 Dietary Exposure of Formaldehyde""; ""5 Formaldehyde Exposure and Health Problems""
505 8 _a""2 Formaldehyde Plays a Role in DNA Methylation and Demethylation""""3 Formaldehyde and RNA Methylation/Demethylation""; ""4 Formaldehyde Is Also Active in Histone Methylation/Demethylation""; ""5 Methylation and Demethylation and Memory""; ""6 Formaldehyde Acting as an Epigenetic Factor in Formation and Loss of Memory""; ""7 Conclusion""; ""References""; ""Chapter 4: Dehydration, Formaldehyde, and Age-Related Cognitive Impairment""; ""1 Introduction""; ""2 A Progressive Dehydration as Aging""; ""3 Diminished Thirst Sensation as Aging""
505 8 _a""2.4.3 From Reducing Sugar Decomposition""""2.4.4 Formaldehyde from Dimethylaminoethanol, Dimethylglycine, and Sarcosine (N-Methylglycine)""; ""2.4.5 From Substrates Containing the CH3N or CH3O Group Mediated by Cytochrome P-450 System""; ""2.5 Oxidative Stress Produces Formaldehyde""; ""2.5.1 SSAO Catalyzes Methylamine to Generate Formaldehyde""; ""2.5.2 Formaldehyde from Glycine Oxidation by MPO""; ""2.5.3 Cells Produce Reactive Oxygen Species (ROS) in the Presence of Formaldehyde and Vice Versa""; ""2.6 From Intestinal Flora""; ""2.7 From Oxidative Demethylation""
505 8 _a""3 Formaldehyde Metabolic Pathways""""3.1 Mitochondrial ALDH2 Pathway""; ""3.2 Glutathione (GSH)-Dependent Pathway""; ""3.3 Intestinal Microbiota""; ""3.4 Synthesis of THF""; ""3.5 Reaction with Biomacromolecules Such as Protein, DNA, and RNA""; ""3.5.1 The Reaction Between Formaldehyde and Proteins""; ""3.5.2 The Reaction Between Formaldehyde and Nucleic Acids""; ""3.5.3 The Cross-Links of Proteins and Nucleic Acids Induced by Formaldehyde""; ""4 Conclusion""; ""References""; ""Chapter 3: Formaldehyde Playing a Role in (De)methylation for Memory""; ""1 Introduction""
505 8 _a""5.1 Acute Toxicosis""""5.2 Impairment and Symptoms of Intoxication""; ""6 Formaldehyde in Biological Evolution and Metabolism""; ""6.1 The Role of Formaldehyde in Biological Evolution""; ""6.2 The Metabolism of Formaldehyde""; ""7 Conclusion""; ""References""; ""Chapter 2: Metabolism of Formaldehyde In Vivo""; ""1 Introduction""; ""2 Endogenous Formaldehyde Generation""; ""2.1 From Environment""; ""2.2 From Food""; ""2.3 Formaldehyde in One-Carbon Circle""; ""2.4 Formaldehyde from Biochemical Compounds""; ""2.4.1 From Protein Denaturation""; ""2.4.2 From Lipid Oxidation""
520 3 _aThis book introduces important, new knowledge regarding formaldehyde, especially endogenous formaldehyde, revealing its many key roles in the human body. It reviews the relationship between endogenous formaldehyde and cognition as well as age-related cognitive impairment, by discussing different aspects such as formaldehyde metabolism, its function in the brain, links with epigenetics and neurophysiology, and epidemiological and clinical investigations. The author also provides suggestions on how to prevent cognitive impairment resulting from excess endogenous formaldehyde. This book appeals to all readers who are interested in cognitive science and toxicology.
588 0 _aOnline resource; title from PDF title page (Ebsco, viewed October 26, 2017).
988 _aEBOOK, EBSPRINGER_2017
650 7 _2embne
_9139809
_aProductos químicos
856 4 0 _uhttps://go.openathens.net/redirector/universidadeuropea.es?url=http://link.springer.com/10.1007/978-94-024-1177-5
_zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942 _2lcc
_cLE
998 _b02/2018
_dz
_e-
_zSI