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008			171011t20172017sz a ob 000 0 eng d
020			_a3319658530 _q(electronic bk.)
020			_a9783319658537 _q(electronic bk.)
020			_z3319658514 _q(hardcover : alk. paper)
020			_z9783319658513 _q(hardcover : alk. paper)
040			_aYDX _beng _erda _cYDX _dN$T _dGW5XE _dN$T _dMMU _dOCLCO _dOCLCF _dTFH _dOCLCO _dUAB _dOCLCO _dMERER _dOCLCO _dIOG _dCOO _dAZU _dUPM _dVT2 _dOCLCO _dES-MaUEC _bspa
050		4	_aRM301.41 _b2017 EB
245	0	0	_aSigma proteins : _bevolution of the concept of sigma receptors _cFelix J. Kim, Gavril W. Pasternak, editors.
264		1	_aCham, Switzerland _bSpringer International Publishing _c2017
264		4	_c2017
300			_a1 recurso en línea (viii, 330 páginas) _bilustraciones (algunas a color)
336			_aTexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_atext file _bPDF
490	0		_aHandbook of experimental pharmacology _x1865-0325 _vvolume 244
500			_a _bSpringer Biomedical and Life Sciences eBooks 2017 English+International
504			_aIncluye referencias bibliográficas
505	0		_aIntroduction to sigma proteins: evolution of the concept of sigma receptors / Felix J. Kim -- Structural insights into sigma1 function / Andrew Kruse -- 3d homology model of sigma1 receptor / Erik Laurini, Domenico Marson, Maurizio Fermeglia, Sabrina Pricl -- Medicinal chemistry of [sigma]1 receptor ligands: pharmacophore models, synthesis, structure affinity relationships, and pharmacological applications / Frauke Weber, Bernhard Wünsch -- Sigma-1 ([sigma]1) receptor in memory and neurodegenerative diseases / Tangui Maurice, Nino Goguadze -- Sigma-1 receptor and neuronal excitability / Saïd Kourrich -- Sigma-1 receptor and pain / Manuel Merlos, Luz Romero, Daniel Zamanillo, Carlos Plata-Salamán, José Miguel Vela -- Allosteric modulation of opioid g-protein coupled receptors by sigma1 receptors / Gavril W. Pasternak -- A role for sigma receptors in stimulant self-administration and addiction / Jonathan L. Katz, Takato Hiranita, Weimin C. Hong, Martin O. Job, Christopher R. McCurdy -- Sigma receptors and alcohol use disorders / Valentina Sabino, Pietro Cottone -- Sigma1 pharmacology in the context of cancer / Felix J. Kim, Christina M. Maher -- Molecular probes for imaging the sigma-2 receptor: in vitro and in vivo imaging studies / Chenbo Zeng, Elizabeth S. McDonald, Robert H. Mach.
520	3		_a"Two sigma receptor subtypes have been proposed, sigma1 and 2. Much of our understanding of this system is based on biochemical and pharmacological characterization of the cloned sigma1 receptor subtype (Sigma1). It has become clear that sigma receptors are not canonical receptors. Sigma1 is highly conserved among mammalian species, however, it does not share significant homology with any other mammalian protein. Although a range of structurally diverse small molecules bind Sigma1 with high affinity, and it has been associated with a broad range of signaling systems, Sigma1 itself has no known signaling or enzymatic activity. The evolution of this field over nearly four decades has more recently led to a fundamental shift in the concept of "sigma receptors" to what may more accurately and generally be called sigma proteins. Largely based on traditional pharmacologic approaches, the Sigma1 protein has been associated with a broad range of signaling systems, including G-protein coupled receptors, NMDA receptors, and ion channels. Sigma proteins have been linked to a range of physiological processes, including intracellular calcium signaling, neuroprotection, learning, memory, and cognition. Emerging genetic, clinical, and mechanism focused molecular pharmacology data demonstrate the involvement of proteins in a range of pathophysiologies and disorders including neurodegenerative disease, pain, addiction, psychomotor stimulant abuse, and cancer. However, an understanding of the physiological role of sigma proteins has remained elusive. Emerging data associate Sigma1 with chaperone-like activities or molecular scaffold functions. This book aims to provide an updated perspective on this rapidly evolving field undergoing changes in fundamental concepts of key importance to the discipline of pharmacology. It focusses on the reported roles of sigma proteins in pathophysiology and on emergent therapeutic initiatives"--Publisher's description.
650		7	_aMedicamentos _xEfectos fisiológicos _2embne _0(OCoLC)fst01742279 _0 _9168752
700	1		_aKim, Felix J., _eeditor literario
700	1		_aPasternak, Gavril W., _eeditor literario
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=http://link.springer.com/10.1007/978-3-319-65853-7 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
988			_aEBOOK, asignarmaterias, EBSPRINGER_2017
998			_b02/2018 _dz _e- _zSI
999			_c96587 _d96587 _x1