000			04409cam a2200409Ii 4500
001			96563
003			ES-MaUEC
005			20230102112800.0
006			m o d
007			cr |n|||||||||
008			171004s2017 sz ob 000 0 eng d
020			_a3319588117 _q(electronic bk.)
020			_a9783319588117 _q(electronic bk.)
020			_z3319588095
020			_z9783319588094
040			_aYDX _beng _cYDX _dN$T _dEBLCP _dGW5XE _dN$T _dNJR _dN$T _dAZU _dUPM _dMERER _dOCLCF _dIOG _dCOO _dOCLCQ _dES-MaUEC _bspa
050		4	_aQP609.P53 _b2017 EB
245	0	0	_aPhosphodiesterases : _bCNS functions and diseases _cHan-Ting Zhang, Ying Xu, James M. O'Donnell, editors.
264		1	_aCham, Switzerland _bSpringer International Publishing _c2017
300			_a1 recurso en línea
336			_aTexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_atext file _bPDF
490	0		_aAdvances in Neurobiology _vv.17
500			_a _bSpringer Biomedical and Life Sciences eBooks 2017 English+International
504			_aIncluye referencias bibliográficas
505	0		_aPart I. PDEs and Signaling, Circuitry, and Implications of CNS Functions and Disorders -- 1. Phosphodiesterase Diversity and Signal Processing within cAMP Signaling Networks -- 2. Current Understanding of PDE10A in the Modulation of Basal Ganglia Circuitry -- 3. Interaction of Cdk5 and cAMP/PKA Signaling in the Mediation of Neuropsychiatric and Neurodegenerative Diseases -- 4. The PDE4 cAMP-specific Phosphodiesterases: Targets for Drugs with Antidepressant and Memory-enhancing Action -- 5. Phosphodiesterase-4B as a Therapeutic Target for Cognitive Impairment and Obesity-related Metabolic Diseases -- Part II. PDEs in Cognition of Aging and Alzheimer's Disease -- 6. From age-related Cognitive Decline to Alzheimer's Disease: A Translational Overview of the Potential role for Phosphodiesterases -- 7. The Past, Present, and Future of Phosphodiesterase-4 Modulation for age-induced Memory Loss -- 8. A Role for Phosphodiesterase 11A (PDE11A) in the Formation of Social Memories and the Stabilization of Mood -- 9. Role of PDE9 in Cognition -- Part III. PDEs in Parkinson's and Huntington's Diseases -- 10. Regulation of Striatal Neuron Activity by Cyclic Nucleotide Signaling and Phosphodiesterase Inhibition: Implications for the Treatment of Parkinson's Disease -- 11. Role of Phosphodiesterases in Huntington's Disease -- Part IV. PDEs and Psychiatric Disorders -- 12. The role of Phosphodiesterase-2 in Psychiatric and Neurodegenerative Disorders -- 13. Phosphodiesterase 1: A Unique Drug Target for Degenerative Diseases and Cognitive Dysfunction -- 14. PDE Inhibitors for the Treatment of Schizophrenia -- Part V. PDEs and Others -- 15. Targeting Phosphodiesterases in Pharmacotherapy for Substance Dependence -- 16. Genetic Understanding of Stroke Treatment: Potential role for Phosphodiesterase Inhibitors -- 17. A unique sub-pocket for Improvement of Selectivity of Phosphodiesterase Inhibitors in CNS.
520	3		_aPDEs are a family of enzymes that catalyze the hydrolysis of intracellular cyclic neucleotides. They are implicated in a number of disorders and dysfunctions and PDE inhibitors have already proven to be effective therapies for erectile dysfunction, COPD, and psoriatic arthiritis. This family of enzymes also plays a role in diseases and disorders of the CNS such as depression, anxiety, schizophrenia, and Alzheimer's Disease. Unfortunately no effective PDE inhibitors have been developed for the treatment of these diseases. The proposed book will be a comprehensive overview of the current state of basic and translational research on PDE inhibitors written by internationally recognized experts. Authors will also discuss potential PDE subtypes and splice variants in the hopes that this will spur more creative approaches to PDE targeting drugs.
650		7	_aSistema nervioso central _xEnfermedades _2embne _0(OCoLC)fst01036114 _0 _9188115
700	1		_aO'Donnell, James M.
700	1		_aXu, Ying.
700	1		_aZhang, Han-Ting.
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=http://link.springer.com/10.1007/978-3-319-58811-7 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
988			_aEBOOK, asignarmaterias, EBSPRINGER_2017
998			_b02/2018 _dz _e- _zSI
999			_c96563 _d96563 _x1