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_b2017 EB
066 _c(S
245 0 0 _aBiochemical Basis and Therapeutic Implications of Angiogenesis
_cedited by Jawahar L. Mehta, Pankaj Mathur, Naranjan S. Dhalla.
250 _a2nd ed. 2017.
264 1 _aCham, Switzerland
_bSpringer International Publishing :
_bImprint
_bSpringer International Publishing
_c2017
300 _a1 recurso en línea (ix, 548 páginas)
_bilustraciones (algunas a color)
336 _aTexto
_btxt
_2rdacontent
337 _aelectrónico
_bc
_2rdamedia
338 _arecurso electrónico
_bcr
_2rdacarrier
347 _atext file
_bPDF
490 0 _aAdvances in Biochemistry in Health and Disease
_v6
500 _a
_bSpringer Biomedical and Life Sciences eBooks 2017 English+International
505 0 _aPart1. Molecular Mechanisms in Angiogenesis -- 1. Endothelial Growth Factor Receptors in Angiogenesis -- 2. The Role of Integrins in Angiogenesis -- 3. Toll-Like Receptors in Angiogenesis -- 4. Vascular Stem Cells in Regulation of Angiogenesis -- 5. Role of Transforming Growth Factor Beta Family in Angiogenesis -- 6. Angiogenesis-based Strategy by Hepatocyte Growth Factor for the Treatment of Ischemic Organ Diseases: From Biology to Clinical Trials -- 7. Functions of MicroRNAs in Angiogenesis -- 8. Mast Cells in Angiogenesis. The role of Angiogenic Cytokines -- Part2. Therapeutic Implications of Angiogenesis in Cancer -- 9. Therapeutic Implications of Angiogenesis in Cancer -- 10. The Role of Angiogenesis in Non-small Cell Lung Cancer Tumor Behavior -- 11. Angiogenesis and Prostate Cancer: Friends or Foes -- Part3. Therapeutic Implications of Angiogenesis in Eye Disorders -- 12. Angiogenesis-based Therapies for Eye Diseases -- 13. Anti-Angiogenesis Therapy in Diabetic Retinopathy -- Part4. Therapeutic Implications of Angiogenesis in Cardiovascular Disorders and Peripheral Vascular Disease -- 14. Therapeutic Angiogenesis, Cell Therapy and Peripheral Vascular Disease -- 15. Cell-based Therapy in Ischemic Heart Disease -- 16. Angiogenesis and Atherosclerosis -- 17.microRNAs, Angiogenesis and Atherosclerosis -- 18. Trials of Angiogenesis Therapy in Patients with Ischemic Heart Disease -- Part5. Therapeutic Implications of Angiogenesis in Miscellaneous Disease States -- 19. Perspectives in New Advances in Retinal Neovascularization Pathogenesis and Therapeutic Approaches -- 20. Role of Estrogens and Androgens in Angiogenesis -- 21. Brain Angiogenesis after Stroke -- 22. Stimulated Microgravity and Induction of Angiogenesis; A New Perspective in Wound Healing -- 23. Role of Skeletal Muscle Angiogenesis in Peripheral Artery Disease.
520 3 _aThis book covers the latest developments in the therapeutic implications of angiogenesis, ranging from angiogenesis in the brain, angiogenesis in cancer, angiogenesis' role in atherosclerosis and heart disease as well as metabolic disorders and peripheral vascular disease. The book is comprehensive in its coverage of angiogenesis in a diverse set of diseases and examines the role of cellular and subcellular structures during the development of angiogenesis. Well-organized and thorough, this is an ideal book for researchers and biomedical engineers working in the field of therapeutic implications of angiogenesis. This book also: Covers the basics of the physiology of angiogenesis, including VEGF pathways in angiogenesis, integrins in angiogenesis, angiogenesis and exercise physiology, and more Details the role of angiogenesis in atherosclerosis and heart disease, including vascular endothelial growth factor and atherosclerotic plaque progression as well as angiogenesis and heart failure Illustrates in detail brain angiogenesis after stroke and the relationship between angiogenesis and Alzheimer's disease.
650 7 _aCancer
_xResearch.
_2fast
_0(OCoLC)fst00845497
_9139308
_0comprobar BNE19900970859
700 1 _aDhalla, Naranjan S.
_eeditor literario
_984616
700 1 _aMathur, Pankaj,
_eeditor literario
700 1 _aMehta, Jawahar L.,
_eeditor literario
_984651
856 4 0 _uhttps://go.openathens.net/redirector/universidadeuropea.es?url=http://link.springer.com/10.1007/978-3-319-61115-0
_zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
880 8 _6505-00/(S
_a4 TGFβ Co-receptors in Angiogenesis.
880 8 _6505-00/(S
_a4.2.1 Therapeutic Applications4.3 Pro-angiogenic Therapies; 5 Conclusion; References; Chapter 2: The Role of Integrins in Angiogenesis; 1 Introduction; 2 Bidirectional Signaling by Integrins Regulates Cellular Fate; 3 Integrin Binding to Proteolytic Protein Fragments; 4 Crosstalk of Integrins with Other Signaling Pathways; 4.1 Notch Signaling; 4.2 VEGF Signaling; 4.3 TGF-β Signaling; 5 Integrin Inhibition in Tumor Angiogenesis; 6 Integrin Inhibitors in Clinical Development; 6.1 GLPG0187; 6.2 Cilengitide; 6.3 ATN-161; 6.4 DI17E6; 7 Conclusions; References.
880 8 _6505-00/(S
_aChapter 5: Role of Transforming Growth Factor Beta Family in Angiogenesis1 TGFβ Molecule Family- Sources, Activation and Regulation of Transcription; 1.1 The TGFβ family; 1.2 TGFβ Sources; 1.3 Synthesis and Activation of TGFβ; 1.4 Regulation of Transcription by TGFβ; 1.5 TGFβ's Role in Angiogenesis; 2 TGFβ Receptors and Signalling; 2.1 Canonical SMAD Signalling; 2.2 Non-canonical Signalling Pathways; 3 TGFβ and Endothelial Sprouting, Proliferation and Permeability; 3.1 Endothelial Sprouting; 3.2 Endothelial Permeability; 3.3 Endothelial Proliferation and Migration.
988 _aEBOOK, asignarmaterias, EBSPRINGER_2017
998 _b02/2018
_dz
_e-
_zSI
999 _c96556
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