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999			_c96547 _d96547 _x1
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003			ES-MaUEC
005			20230102112759.0
006			m o d
007			cr |n|||||||||
008			170927s2017 sz o 000 0 eng d
020			_a3319632604 _q(electronic bk.)
020			_a9783319632605 _q(electronic bk.)
020			_z3319632590
020			_z9783319632599
040			_aYDX _beng _cYDX _dN$T _dEBLCP _dGW5XE _dN$T _dYDX _dNJR _dAZU _dUPM _dMERER _dOCLCO _dIOG _dCOO _dOCLCO _dOCLCQ _dJG0 _dOCLCO _dOCLCA _dES-MaUEC _bspa
050		4	_aRC346 _b2017 EB
066			_c(S
245	0	0	_aObesity and brain function _cLiliana Letra, Raquel Seiça, editors.
264		1	_aCham, Switzerland _bSpringer International Publishing _c2017
300			_a1 recurso en línea
336			_aTexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_atext file _bPDF
490	0		_aAdvances in neurobiology _x2190-5215 _vv. 19
500			_a
505	0		_6880-01 _aPreface; Contents; Part I: Adipose Tissue Biology and Crosstalks; Chapter 1: Function and Dysfunction of Adipose Tissue; 1.1 Adipose Tissue Structure; 1.2 Metabolic Functions of the Adipose Tissue; 1.2.1 Mechanisms of Nutrient Uptake and Storage in Adipocytes; 1.2.2 Cholesterol Fluxes; 1.3 Endocrine Function of the Adipose Tissue; 1.3.1 Leptin; 1.3.2 Adiponectin; 1.3.3 Resistin; 1.3.4 Other Adipose Tissue Products; 1.4 Dysregulation of Adipose Tissue Function in Obesity; 1.4.1 Dysregulation of Lipid Metabolism; 1.4.2 Adipose Tissue Hypoxia
505	8		_a2.2 Brain Circuits of Food Intake Regulation2.2.1 Hypothalamus; 2.2.1.1 Arcuate Nucleus; 2.2.1.2 Paraventricular Nucleus; 2.2.1.3 Ventromedial Hypothalamus and Dorsomedial Hypothalamus; 2.2.1.4 Lateral Hypothalamic Area; 2.2.1.5 Glucose and Lipid Sense Neurons; 2.2.2 Brainstem; 2.2.3 Brain Reward Circuits; 2.3 Neuronal and Humoral Outputs to the Peripheral Organs; 2.3.1 Central Nervous System and White Adipose Tissue; 2.3.2 Central Nervous System and Brown Adipose Tissue; 2.4 Concluding Remarks; References; Chapter 3: Neuroendocrinology of Adipose Tissue and Gut-Brain Axis; 3.1 Introduction
505	8		_a3.2 Gastrointestinal Signals to the Brain3.2.1 Orexigenic Factors; 3.2.1.1 Ghrelin; 3.2.1.2 Endocannabinoids; 3.2.2 Anorexigenic Factors; 3.2.2.1 Cholecystokinin; 3.2.2.2 Glucagon-like-Peptide-1; 3.2.2.3 Glucagon-like Peptide-2; 3.2.2.4 Peptide Tyrosine Tyrosine; 3.2.2.5 Oxyntomodulin; 3.2.2.6 Gastric Leptin; 3.2.2.7 Apolipoprotein-IV; 3.2.2.8 Neurotensin; 3.2.2.9 Secretin; 3.2.2.10 GUT Microbiota; 3.3 Endocrine Pancreas-Derived Signals to the Brain; 3.3.1 Insulin; 3.3.2 Glucagon; 3.3.3 Amylin; 3.3.4 Pancreatic Polypeptide; 3.4 Adipose Tissue-Derived Signals to the Brain; 3.4.1 Leptin
505	8		_a3.4.2 Adiponectin3.4.3 Resistin; 3.4.4 Apelin; 3.5 Concluding Remarks; References; Part II: Obesity as a Risk Factor for Neurological Disease; Chapter 4: Hypothalamic Dysfunction in Obesity and Metabolic Disorders; 4.1 Introduction; 4.2 Changes of Hypothalamic Food Intake Regulation Controlled by the Hypothalamus; 4.2.1 Obesity Induces Insulin, Leptin, and Ghrelin Resistance in the Hypothalamus; 4.2.1.1 Hypothalamic Insulin Resistance in Obesity; 4.2.1.2 Hypothalamic Leptin Resistance in Obesity; 4.2.1.3 Hypothalamic Ghrelin Resistance in Obesity
520	3		_aThis compendium provides a wide view covering everything from molecular mechanisms and risk factors for neurological disorders to the effects of bariatric surgery on brain function and functional neuroimaging applied to obesity research. The impact of obesity on brain function and the development of neurodegenerative and neuroinflammatory disorders has been understudied, despite the recent proliferation of obesity research. Among the topics covered are adipose biology, the adipose tissue - gut - brain axis, brain energy metabolism, dementia, cerebrovascular disease, and multiple sclerosis.
588	0		_aVersión impresa
988			_aEBOOK, EBSPRINGER_2017
650		7	_2embne _aSistema nervioso _xEnfermedades _9169088
650		7	_2embne _aNeurología _9139040
700	1		_aLetra, Liliana.
700	1		_aSeica, Raquel.
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=http://link.springer.com/10.1007/978-3-319-63260-5 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
880	8		_6505-01/(S _a1.4.3 Activation of Stress and Inflammatory Pathways by Lipid Mediators and Hypoxia: Consequences for Inflammatory Cell Recruitment1.4.3.1 Adipose Tissue Immune System: Recruitment of Inflammatory Cells and Secretion of Inflammatory Cytokines; 1.4.4 Inhibition of Nutrient Uptake by Inflammatory Stimuli: Insulin Resistance and PPARγ Inhibition; 1.4.5 Activation of Angiogenesis; 1.4.5.1 Pro and Antiangiogenic Factors; 1.4.6 Inflammatory Feedback in Adipose Tissue: Unifying Mechanism; References; Chapter 2: The Role of Brain in Energy Balance; 2.1 Introduction
942			_2lcc _cLE
998			_b02/2018 _dz _e- _zSI