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001			96511
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005			20230102112757.0
006			m o d
007			cr |n|||||||||
008			170913s2017 sz o 000 0 eng d
020			_a331960189X _q(electronic bk.)
020			_a9783319601892 _q(electronic bk.)
020			_z3319601881
020			_z9783319601885
040			_aYDX _beng _cYDX _dN$T _dEBLCP _dGW5XE _dN$T _dOCLCF _dNJR _dAZU _dUPM _dMERER _dIOG _dCOO _dOCLCQ _dES-MaUEC _bspa
050		4	_aRA1231.M52 _b2017 EB
245	0	0	_aNeurotoxicity of metals _cMichael Aschner, Lucio G. Costa, editors.
264		1	_aCham, Switzerland _bSpringer International Publishing _c2017
300			_a1 recurso en línea
336			_aTexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_atext file _bPDF
490	0		_aAdvances in neurobiology _vv. 18
500			_a _bSpringer Biomedical and Life Sciences eBooks 2017 English+International
505	0		_aPart I: Developmental Neurotoxicity; Developmental Neurotoxicity of Lead; Introduction; Developmental Exposures to Lead; Neurobehavioral Effects of Lead; Molecular Mechanisms of Neurotoxicity; Developmental Exposures to Lead and Alzheimer's Disease; Conclusions; References; Manganese and Developmental Neurotoxicity; Manganese in the Environment; Airborne Particles; Deposited Dust; Surface Soil; Edible Vegetables; Drinking Water; Toxicology and Biomarkers; Metabolism; Pediatric Absorption; Biomarkers; Effects on Cognitive Functions; Intellectual Ability
505	8		_aExecutive Function Memory; Academic Achievement; Effects on Motor Functions; Behavior; Attention Deficit Hyperactivity Disorder; Autism Spectrum Disorder; Other Behavioral Outcomes; Effects on Olfactory Function; References; Inherited Disorders of Manganese Metabolism; Introduction; SLC30A10; SLC39A14; SLC39A8; Concluding Perspectives; References; Part II: Neurodegenerative Disorders; Chemical Speciation of Selenium and Mercury as Determinant of Their Neurotoxicity; Introduction; Selenium in the Environment and in the Living Organisms; Selenium: Neurotoxic or Neuroprotector?
505	8		_aFrom Selenide to Selenoproteins Selenoproteins in the Brain; Mercury in the Environment and in the Living Organisms; Inorganic Mercury Neurotoxicity; Organic Mercury Neurotoxicity; Selenium and Mercury: Brain Antagonistic Interactions; Selenium as Antagonist of Inorganic Mercury Neurotoxicity; Selenium as an Antagonist of the Neurotoxicity Induced by Organic Mercury; Conclusion; References; Metals and Paraoxonases; Introduction; PON1; Human Polymorphisms of PON1 and Definition of PON1 Status; Modulation of PON1 Activity and Expression; PON2
505	8		_aIIS Signaling and Its Role in the Brain Mn and Insulin/IGF Homeostasis; HD Pathobiology; Mn Dysregulation in HD; IIS Dysregulation in HD; Autophagy Deficits in HD, Potential Links to Mn and IIS; Mitochondrial Pathology in HD, Possible Links to Mn and IIS; IIS Signaling and Mn in Other NDDs; PD and IIS/Mn; AD and IIS/Mn; ALS and IIS/Mn; Autophagy in Other Neurodegenerative Diseases; Manganese Toxicity and IGF; The Co-regulation of ATM, Mn, and Insulin/IGF; IIS Signaling, Mn, and Cancer; Conclusions; References; Occupational Metal Exposure and Parkinsonism; Introduction
505	8		_aPON2 as an Intracellular Antioxidant Enzyme Modulation of PON2; PON3: Activity, Polymorphisms, Physiological Functions, and Modulation; Interactions of Metals with PONs; In Vitro Effects of Metals on PONs; Effects of Metals on PONs: Animal Studies; Metals and PONs: Human Studies; Lead; Arsenic; Methylmercury and Selenium; Cadmium; Other Metals; Potential Mechanisms of PON1 Modulation by Metals; Summary and Conclusions; References; Manganese and the Insulin-IGF Signaling Network in Huntington's Disease and Other Neurodegenerative Disorders; Introduction
520	3		_aIn this book, international authorities address contemporary research in metal neurotoxicity. Essential and non-essential metals play an important role in neurodevelopmental and neurodegenerative diseases. Recent developments in understanding the role of metals in the etiology of these disorders have led to rapid growth in clarifying the pathology of some of the most devastating diseases we face and in identifying potential new therapies. Few books or periodicals have been wholly dedicated to the topic of metals, and this collection is intended to serve as a resource for all researchers interested in metals and their role in health and disease.
650		7	_9138327 _aMetales _xToxicology. _2fast _0(OCoLC)fst01018222 _0
700	1		_aAschner, Michael _4
700	1		_aCosta, Lucio _4 _925385
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=http://link.springer.com/10.1007/978-3-319-60189-2 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
988			_aEBOOK, asignarmaterias, EBSPRINGER_2017
998			_b02/2018 _dz _e- _zSI
999			_c96511 _d96511 _x1