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008			170908t20172017ne a ob 000 0 eng d
020			_a9402411704 _q(electronic bk.)
020			_a9789402411706 _q(electronic bk.)
020			_z9402411682 _q(hardcover : alk. paper)
020			_z9789402411683 _q(hardcover : alk. paper)
040			_aYDX _beng _cYDX _dN$T _dEBLCP _dMMU _dN$T _dGW5XE _dYDX _dCASUM _dTFH _dAZU _dUPM _dMERER _dUAB _dIOG _dCOO _dOCLCO _dOCLCQ _dOCLCO _dJG0 _dOCLCO _dOCLCA _dES-MaUEC _bspa
050		4	_aQR182 _b2017 EB
245	0	0	_aImmune metabolism in health and tumor _cBin Li, Fan Pan, editors.
264		1	_aDordrecht, The Netherlands _bSpringer International Publishing _c2017
264		4	_c2017
300			_a1 recurso en línea (v, 223 páginas) _bilustraciones (algunas a color)
336			_astill image _bsti _2rdacontent
336			_aTexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_atext file _bPDF
490	0		_aAdvances in experimental medicine and biology _x2214-8019 _vvolume 1011
500			_a
504			_aIncluye referencias bibliográficas
505	0		_aMetabolism in immune cell differentiation and function / Nicole M. Chapman, Sharad Shrestha, Hongbo Chi -- Metabolic regulation of T cell immunity / Paolo D. A. Vignali, Joseph Barbi, Fan Pan -- Transcriptional regulation of T cell metabolism reprograming / Jinxia Zhang, Guoyu Bi, Yu Xia, Pingfei Li, Xiaofei Deng, Zhengping Wei [and others] -- Adipose tissue-resident regulatory T cells / Fuxiang Zhu, Aiting Wang, Yangyang Li, Rui Liang, Dan Li, Bin Li -- Immune cell metabolism in tumor microenvironment / Yongsheng Li, Yisong Y. Wan, Bo Zhu -- Regulation of metabolism across different subsets of t cells in cancer / Xuerui Luo, Fuxiang Zhu, Zuojia Chen, Dan Li, Bin Li -- Innate and adaptive immune cell metabolism in tumor microenvironment / Duojiao Wu.
520	3		_a"This book offers a broad overview of the concepts and research findings in immunometabolism. The immune system is made up of numerous different cell types, pathways, and components that must be able to respond rapidly to a pathogen or cancer, but must also remain quiescent in the absence of challenges. Immune cells rely on metabolic pathways to adapt to changing environments and stimuli. Additionally, these cells can be modified in function or fate by fluctuations in available nutrients. The chapters in this book describe ways in which immune cells utilize and are regulated by metabolic pathways. Topics include how immune-cell metabolism shapes immune homeostasis, and how dysregulation of these pathways can lead to immune disorders. In different contexts, such as a tumor microenvironment, immune-cell function and identity may be modified not only by cytokines and checkpoint molecules, but also by nutrient availability and other metabolic stimuli. Transcriptional reprogramming confers many of the changes in immune cell metabolism that are seen when a T-cell, for example, undergoes activation or functional adaptation to different environments. Lastly, immune cells can destructively or protectively participate in human metabolic homeostasis or disorders. This book summarizes immune-metabolism from a variety of different perspectives, including the ways in which metabolic cues, pathways, and requirements of immune cells change in conditions of homeostasis and activation. The exploration of the significance of metabolic checkpoints and other cues, particularly in the context of cancer and immune disorders, may form the foundation for the development of therapeutics"--Publisher's description.
588			_aDescription based on online resource; title from pdf title page (SpringerLink, viewed September 11, 2017).
988			_aEBOOK, EBSPRINGER_2017
650		7	_2embne _aInmunología _9138330
650		7	_2embne _aMicrobiología _9138684
700	1		_aLi, Bin _c(Immunologist), _eeditor literario _977900
700	1		_aPan, Fan _c(Immuno-oncologist), _eeditor literario
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=http://link.springer.com/10.1007/978-94-024-1170-6 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
998			_b02/2018 _dz _e- _zSI