000			05226cam a2200469Ki 4500
001			96486
003			ES-MaUEC
005			20230102112756.0
006			m o d
007			cr |n|||||||||
008			170906s2017 sz ob 000 0 eng d
020			_a3319601741 _q(electronic bk.)
020			_a9783319601748 _q(electronic bk.)
020			_z3319601725
020			_z9783319601724
040			_aYDX _beng _erda _cYDX _dN$T _dEBLCP _dGW5XE _dN$T _dUAB _dAZU _dYDX _dUPM _dOCLCF _dMERER _dOCLCQ _dESU _dIOG _dCOO _dOCLCO _dJG0 _dOCLCO _dOCLCA _dES-MaUEC _bspa
050		4	_aQP552.G16 _b2017 EB
245	0	0	_aG-protein-coupled receptor dimers _cKatharine Herrick-Davis, Graeme Milligan, Giuseppe Di Giovanni, editors.
264		1	_aCham, Switzerland _bHumana Press _c2017
264		4	_c2017
300			_a1 recurso en línea
336			_aTexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_atext file _bPDF
490	0		_aThe receptors _vv. 33
500			_a _bSpringer Biomedical and Life Sciences eBooks 2017 English+International
504			_aIncluye referencias bibliográficas
505	0		_aDedication; Foreword; On the Question of GPCR Oligomerization; References; Preface; Contents; Part I: Introduction; Chapter 1: Historical Perspectives: From Monomers to Dimers and Beyond, an Exciting Journey in the World of G Protein-Coupled Receptors; 1.1 Introduction; 1.2 The Birth of the Dimerization Concept; 1.3 Establishing the New Concept; 1.4 Oligomers Make the Picture More Complicated; 1.5 Receptor Homo- and Heteromers as New Pharmacological Targets; 1.6 Perspectives; References
505	8		_a2.1.6.1 Determining the Monomeric Quantal Brightness Value2.1.6.2 1 Population or 2 Population Mode; 2.1.6.3 When Does a QB Value Reflect Monomeric and When Dimeric/Oligomeric States?; 2.1.7 Determining the Quaternary Structure of GPCRs and How This May Be Affected by Ligand Binding; 2.1.8 Future Perspectives of SpIDA; References; Chapter 3: Advanced Microscopy Techniques; 3.1 Introduction; 3.2 FRET-Based Microscopy; 3.2.1 Definitions and the Principle of the Method; 3.2.2 Theoretical Basis of the Method; 3.2.3 Practical Implementation of FRET
505	8		_a3.2.3.1 General Requirements for Optical Microscopes Used in FRET Studies3.2.3.2 Two-Photon Absorption Optical Micro-spectroscopy; 3.2.3.3 Determination of FRET Efficiency from Optical Micro-­Spectroscopy Data; 3.2.4 Theoretical Models Used for Information Extraction from Experimental Data; 3.2.4.1 Prediction of FRET Efficiencies for Various Oligomer Configurations; 3.2.4.2 Computation of Average FRET Efficiencies for Mixtures of Oligomers; 3.2.5 Experimental Applications of FRET; 3.2.5.1 FRET Spectrometry; 3.2.5.2 Statistical-Ensemble Approach to FRET
505	8		_a3.2.5.3 Combination Between the Two FRET Approaches3.3 Spatial Fluorescence Correlation Spectroscopy; 3.3.1 Principle of the Method; 3.3.1.1 Generalized Spatial Correlation Function; 3.3.1.2 Spatial Auto-Correlation; 3.3.1.3 Spatial Cross-Correlation and Colocalization; 3.3.2 Practical Implementation of ICCS; 3.3.3 Experimental Applications of Spatial Fluorescence Correlation Spectroscopy; 3.4 Temporal Fluorescence Correlation Spectroscopy; 3.4.1 Principle of the Method; 3.4.2 Theoretical Background of the Method; 3.4.2.1 Generalized Temporal Correlation Function
505	8		_aChapter 2: The Use of Spatial Intensity Distribution Analysis to Examine G Protein-Coupled Receptor Oligomerization2.1 Introduction; 2.1.1 SpIDA Procedure; 2.1.2 Choice of Fluorophore; 2.1.3 Selection of the Expression System; 2.1.4 Establishing Imaging Conditions for SpIDA; 2.1.4.1 Laser Power Intensity Measurement; 2.1.4.2 Laser Spot Beam Waist Radius Size; 2.1.4.3 Analog Detector Calibration; 2.1.4.4 Assessment of White Noise Level; 2.1.5 Laser Scanning Confocal Image Acquisition; 2.1.6 Spatial Intensity Distribution Analysis of Laser Scanning Confocal Images
520	3		_aG-protein-coupled receptors (GPCRs) are believed to be the largest family of membrane proteins involved in signal transduction and cellular responses. They dimerize (form a pair of macromolecules) with a wide variety of other receptors. The proposed book will provide a comprehensive overview of GPCR dimers, starting with a historical perspective and including, basic information about the different dimers, how they synthesize, their signaling properties, and the many diverse physiological processes in which they are involved. In addition to presenting information about healthy GPCR dimer activity, the book will also include a section on their pathology and therapeutic potentials.
650		7	_aBiología molecular _2embne _0(OCoLC)fst00893854 _0 _9139103
700	1		_aDi Giovanni, Giuseppe, _eeditor literario _985071
700	1		_aHerrick-Davis, Katharine, _eeditor literario
700	1		_aMilligan, Graeme. _eeditor literario
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=http://link.springer.com/10.1007/978-3-319-60174-8 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
988			_aEBOOK, asignarmaterias, EBSPRINGER_2017
998			_b02/2018 _dz _e- _zSI
999			_c96486 _d96486 _x1