000			05137cam a2200433 i 4500
999			_c96461 _d96461 _x1
001			96461
003			ES-MaUEC
005			20230102112755.0
006			m o d
007			cr cnu|||unuuu
008			170830s2017 sz a ob 001 0 eng d
020			_a3319561707 _q(electronic bk.)
020			_a9783319561707 _q(electronic bk.)
020			_z3319561685
020			_z9783319561684
040			_aYDX _bspa _cYDX _dN$T _dUAB _dEBLCP _dGW5XE _dDKU _dAZU _dUPM _dMERER _dOCLCQ _dESU _dIOG _dCOO _dES-MaUEC _bspa
050		4	_aHV5801 _b2017 EB
245	0	0	_amGlu receptors _cRichard Teke Ngomba [and 3 others], editors
264		1	_aCham, Switzerland, Switzerland _bHumana Press _c2017
300			_a1 recurso en línea _bilustraciones
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_atext file _bPDF
490	0		_aReceptors _vvolume 31
500			_a
504			_aIncluye referencias bibliográficas e índice
505	0		_aPreface; Contents; Chapter 1: mGlu5 Signaling: A Target for Addiction Therapeutics?; 1.1 Introduction: Pharmacotherapy and Allosteric Modulators; 1.2 Negative Allosteric Modulators Reduce Drug Reward; 1.3 mGlu5 Receptors and Synaptic Plasticity; 1.4 mGlu5 Receptor Expression Changes Across Development of Addiction; 1.5 Cognitive Capacity Is Positively Correlated with Treatment Outcome for Substance Abuse Disorders; 1.6 Amnestic Effects of mGlu5 Inactivation; 1.7 Facilitatory Effects of mGlu5 Activation on Learning, Memory, and Extinction Processes; 1.8 Conclusion; References
505	8		_a3.3.2 Group II mGlu Receptors3.3.3 Group III mGlu Receptors; 3.4 Group I mGlu Receptors and Parkinson's Disease; 3.5 Group II mGlu Receptors and Parkinson's Disease; 3.6 Group III mGlu Receptors and Parkinson's Disease; 3.7 Concluding Remarks; References; Chapter 4: Metabotropic Glutamate 2 (mGlu2) Receptors and Schizophrenia Treatment; 4.1 Schizophrenia; 4.2 Metabotropic Glutamate Receptors; 4.3 Preclinical and Clinical Schizophrenia Assays with mGlu2/3 Receptor Agonists; 4.4 Environmental Events and mGlu2 Expression
505	8		_a4.5 Expression of mGlu2 and 5-HT2A as a GPCR Heteromer in Schizophrenia Treatment4.6 Conclusions; References; Chapter 5: mGlu5: A Metabotropic Glutamate Receptor at the Hub of Hippocampal Information Processing, Persistent Synaptic Plasticity, and Long-Term Memory; 5.1 Introduction; 5.2 Role of mGlu5 in Persistent Forms of Hippocampal Synaptic Plasticity and Memory; 5.2.1 Role of mGlu5 in Persistent LTP and LTP-Related Memory; 5.2.2 Role of mGlu5 in Persistent LTD and LTD-Related Memory; 5.3 Role of mGlu5 in Hippocampal Information Processing; 5.3.1 Neuronal Oscillations
505	8		_a5.3.2 The Role of mGlu5 in Place Fields5.3.3 The Special Case of the CA3 Region; 5.4 mGlu5 at the Hub of Hippocampal Function; References; Chapter 6: Neuroprotective Properties of Glutamate Metabotropic Glutamate Receptors in Parkinson's Disease and Other Brain Disorders; 6.1 Introduction; 6.2 MGluR Localization in the Basal Ganglia Circuitry; 6.3 Neuroprotective Effects of Group I mGluRs; 6.4 Neuroprotective Effects of Group II mGluRs in PD; 6.5 Neuroprotective Effects of Group III mGluRs in PD; 6.6 Neuroprotective Effects of mGluR-Related Drugs in Other Brain Diseases
505	8		_aChapter 2: Supraspinal Metabotropic Glutamate Receptors: An Endogenous Substrate for Alleviating Chronic Pain and Related Affective Disorders2.1 Introduction; 2.2 mGluRs and Pain Processing; 2.3 Group I mGluRs; 2.4 Group II mGluRs; 2.5 Group III mGluRs; 2.6 Conclusion; References; Chapter 3: Metabotropic Glutamate Receptors and Parkinson's Disease: Basic and Preclinical Neuroscience; 3.1 Parkinson's Disease; 3.2 Rationale for Targeting mGlu Receptors for Parkinson's Disease; 3.3 Localization and Function of mGlu Receptors in the Basal Ganglia; 3.3.1 Group I mGlu Receptors
520	3		_aMetabotropic glutamate receptors (mGluRs) are members of the group C family of G-protein-coupled receptors. Eight different mGlu subtypes have been identified and classified into three groups based on amino acid sequence similarity, agonist pharmacology, and the signal transduction pathways to which they couple. They perform a variety of functions in the central and peripheral nervous systems, being involved in learning, memory, anxiety, and the perception of pain. They are found in pre- and postsynaptic neurons in synapses of the hippocampus, cerebellum, and cerebral cortex, as well as other parts of the brain and peripheral tissues. This volume comprises the latest contributions of experts in the field on the role of mGlu receptor in health and disease, following the 8th International meeting on these receptors.
988			_aEBOOK, EBSPRINGER_2017
650		7	_2embne _9140329 _aToxicomanía
700	1		_9676278 _aNgomba, Richard Teke _eeditor literario
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=http://link.springer.com/10.1007/978-3-319-56170-7 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
998			_b02/2018 _dz _e- _zSI