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008			170830s2017 sz a ob 000 0 eng d
020			_a3319585924 _q(electronic bk.)
020			_a9783319585925 _q(electronic bk.)
020			_z3319585916
020			_z9783319585918
040			_aYDX _beng _erda _cYDX _dN$T _dGW5XE _dEBLCP _dN$T _dUAB _dAZU _dUPM _dOCLCF _dMERER _dYDX _dOCLCQ _dESU _dIOG _dSTF _dCOO _dOCLCO _dJG0 _dOCLCO _dOCLCA _dES-MaUEC _bspa
050		4	_aQH600.2 _b2017 EB
245	0	0	_aCentromeres and kinetochores : _bdiscovering the molecular mechanisms underlying chromosome inheritance _cBen E. Black, editor.
264		1	_aCham, Switzerland _bSpringer International Publishing _c2017
300			_a1 recurso en línea _bilustraciones
336			_aTexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_atext file _bPDF
490	0		_aProgress in molecular and subcellular biology _x0079-6484 _vv. 56
500			_a
504			_aIncluye referencias bibliográficas
505	0		_aPreface; Contents; Identification, Organization, and Regulation of Centromere and Kinetochore Components; 1 Use of Mass Spectrometry to Study the Centromere and Kinetochore; Abstract; 1 Discovery of Centromere Proteins Using Anti-centromere Autoantibodies; 2 Identification of Centromere Proteins Using Yeast Genetic Screens; 3 Post-genomics Approaches to Discover Centromere Proteins: RNAi Screening in C. elegans; 4 Identification of Centromere/Kinetochore Proteins by Affinity-Purification Mass Spectrometry (AP-MS); 5 Shotgun Proteomics of Isolated Yeast Kinetochores
505	8		_a2 Reconstituting Centromere and Kinetochore Functions In Vitro2.1 Xenopus Egg Extract as a Versatile System for In Vitro Reconstitution; 3 Application of Frog Egg Extracts to Study Centromere and Kinetochore Function; 3.1 Epigenetic Maintenance of Centromere Identity; 3.2 CCAN Assembly; 3.3 Kinetochore Assembly; 3.4 The Spindle Assembly Checkpoint; 4 Conclusion; References; 4 Centrochromatin of Fungi; Abstract; 1 Introduction; 2 Centromeric DNA Sequence: Many Ways to Shape a Remarkable Genetic Locus; 2.1 The Dark Matter of Fungal Centromeres Lies in the Basal Lineages
505	8		_a2.2 Fission Yeast, Budding Yeast, and the Dimorphic Candida as Models for Centromere Research2.3 Filamentous Fungi Contain Diverse Types of Centromeres; 3 Centrochromatin; 4 Summary; References; 5 Evolutionary Lessons from Species with Unique Kinetochores; Abstract; 1 Introduction; 2 The Kinetochore Complex in Animals and Fungi; 2.1 Similarities and Variations of the Inner Kinetochore in Animals and Fungi; 2.2 The Composition of the Outer Kinetochore Is Highly Conserved in Animals and Fungi; 3 Glimpses into Kinetochore Compositions in Diverse Eukaryotes; 3.1 Supergroup Amoebozoa
505	8		_a3.1.4 CENP-O/P/Q/R/U3.1.5 CENP-T/S/W/X; 3.2 CCAN Organization and Functions; 3.2.1 CCAN Interaction; 3.2.2 The CCAN as a Bridge Between Centromere and Microtubule; 3.2.3 In Vitro Reconstitution of the CCAN; 3.2.4 The CCAN-Dependent Stabilization of Centromere Position; 4 Dynamic Rearrangement of CCAN Organization; 4.1 Reorganization of the CCAN During the Cell Cycle; 4.2 CCAN Organization During Development; 5 Conclusion; Acknowledgements; References; 3 The Power of Xenopus Egg Extract for Reconstitution of Centromere and Kinetochore Function; Abstract; 1 Introduction
505	8		_a6 Shotgun Proteomics of Whole Isolated Mitotic Chromosomes7 Use of Mass Spectrometry to Study Kinetochore Protein Complexes; 8 Use of CLMS Mass Spectrometry to Study the Ultra-structure of Kinetochore Protein Complexes; 9 Future Prospects; Acknowledgements; References; 2 Critical Foundation of the Kinetochore: The Constitutive Centromere-Associated Network (CCAN); Abstract; 1 Introduction; 2 Centromere; 2.1 Centromere Organization; 2.2 CENP-A Is a Critical Epigenetic Mark for Centromere Specification; 3 CCAN Organization; 3.1 CCAN Subcomplexes; 3.1.1 CENP-C; 3.1.2 CENP-H/I/K/M; 3.1.3 CENP-L/N
520	3		_aThis book presents the latest advances concerning the regulation of chromosome segregation during cell division by means of centromeres and kinetochores. The authors cover both state-of-the-art techniques and a range of species and model systems, shedding new light on the molecular mechanisms controlling the transmission of genetic material between cell divisions and from parent to offspring. The chapters cover five major areas related to the current study of centromeres and kinetochores: 1) their genetic and epigenetic features, 2) key breakthroughs at the molecular, proteomic, imaging and biochemical level, 3) the constitutive centromere proteins, 4) the role of centromere proteins in the physical process of chromosome segregation and its careful orchestration through elaborate regulation, and 5) intersections with reproductive biology, human health and disease, as well as chromosome evolution. The book offers an informative and provocative guide for newcomers as well as those already acquainted with the field.
988			_aEBOOK, asignarmaterias, EBSPRINGER_2017
650		7	_aCromosomas _2embne _0(OCoLC)fst00850278 _9139992
700	1		_aBlack, Ben E.
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=http://link.springer.com/10.1007/978-3-319-58592-5 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
998			_b02/2018 _dz _e- _zSI