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020 _a3319630016
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020 _a9783319630014
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066 _c(S
050 4 _aRA776.75
_b2017 EB
245 0 0 _aHormones in ageing and longevity
_cSuresh Rattan, Ramesh Sharma, editors.
264 1 _aCham, Switzerland
_bSpringer International Publishing
_c2017
300 _a1 recurso en línea
336 _aTexto
_btxt
_2rdacontent
337 _aelectrónico
_bc
_2rdamedia
338 _arecurso electrónico
_bcr
_2rdacarrier
347 _atext file
_bPDF
490 0 _aHealthy ageing and longevity
_vv. 6
500 _a
_bSpringer Biomedical and Life Sciences eBooks 2017 English+International
504 _aIncluye referencias bibliográficas e índice
505 0 _aPreface; Contents; History and Conflux; 1 How Hormones, as Ancient Signalling Molecules, Regulate Diverse Biological Processes Through Evolution; Abstract; 1.1 Introduction; 1.2 Evolution: Hormones Are Messengers but Do not Carry Any Information; 1.3 Environmental Cues and Endocrine Cascades; 1.4 Receptors: Key to the Understanding of the Mechanism of Hormone Action; 1.5 Membrane Receptors; 1.6 Nuclear Receptors; 1.7 Chromatin Structure and Hormonal Regulation; 1.8 Integration of the Membrane- and Nuclear Receptor-Linked Hormonal Pathways; 1.9 Hormones and Their Actions Through Evolution
505 8 _a3.2 Glucocorticoid Cascade Hypothesis3.2.1 Glucocorticoids in Health; 3.2.2 Glucocorticoids in Clinical Science; 3.2.3 Glucocorticoids Side Effects; 3.3 Glucocorticoids in Aging; 3.3.1 Glucocorticoids, HPA Axis and Aging; 3.3.2 Glucocorticoids Extra- and Intra-cellular Bioavailability with Age; 3.3.3 Glucocorticoids Genomic Signaling as a Function of Age; 3.3.4 Glucocorticoids Non-genomic Signaling in Aging; 3.4 Management of Glucocorticoids Induced Age-Related Complications via GR Signaling Pathway Modulation; 3.5 Conclusion; Acknowledgements; References
505 8 _a4 Zinc, Insulin and IGF-I Interplay in AgingAbstract; 4.1 Introduction; 4.2 Biological Functions of Zn; 4.3 Zinc in Biogerontology; 4.3.1 Zn Supplements and Longevity; 4.3.2 Zn Regulatory Mechanisms and Longevity; 4.4 Zinc Insulin Interplay; 4.4.1 Zinc Action on Insulin Activity; 4.4.2 Influence of Zinc Machinery on Insulin Activity; 4.4.3 Insulin Action on Zn Homeostasis; 4.5 Zinc IGF-1 Interplay; 4.5.1 Modulation of IGF-1 Action by Zn Signals; 4.5.2 Modulation of Zn Homeostasis by IGF-1; 4.6 Conclusions; References; Supplementary Data; Human:; Mus Musculus:
505 8 _a5 Growth Hormone and IGF-1 Axis in Aging and LongevityAbstract; 5.1 Introduction; 5.2 Decline of the GH-IGF-1 Axis and Replacement Therapy in Elderly People; 5.3 Loss-of- or Reduction-of Function Mutations of Genes in the GH Signal Transduction Pathway Consistently Extend Lifespan in a Range of Experimental Animals; 5.4 Lifespan Extension by Single Gene Mutations Related to the Reduction of the GH-IGF-1 Axis; 5.5 Genes Downstream of IGF-1 Signaling that Lead to Lifespan Extension; 5.6 Evidence in Humans Indicating a Relation Between Longevity and Inhibition of the GH-IGF-1 Axis
520 3 _aThis multi-chapter book focuses on one of the hottest topics in ageing research - the role of hormones in health and longevity, offering a comprehensive and up-to-date overview of their mechanistic roles in health, ageing and longevity. Hormones are an excellent system of communication between cells and tissues within an organism, and they coordinate a wide range of processes in biological systems, including neuroendocrine and immunological controls. The book offers insights into the latest significant advances in our understanding of the mechanisms of hormonal signaling that control a variety of processes involved in development and ageing. It is divided into four parts: Part I includes a review of the hundred-year history of hormones by the illustrious hormone biochemist Dr. J.R. Tata. Part II presents various chapters on the hormones involved in growth, stress and metabolism, while Part III addresses the hormones controlling cognition and rhythms in ageing processes. Lastly, Part IV discusses the hormones affecting reproduction, immunity and life span. It also explores the use of hormones as pharmaceuticals to maintain health in the elderly. It is a valuable resource for those working in the area of hormone signaling in general and in the field of ageing research in particular.
650 7 _9141231
_aEnvejecimiento
_xHormone therapy.
_2fast
_0(OCoLC)fst00800312
_0
700 1 _aRattan, Suresh I. S.,
_eeditor literario
_984397
700 1 _aSharma, Ramesh,
_eeditor literario
856 4 0 _uhttps://go.openathens.net/redirector/universidadeuropea.es?url=http://link.springer.com/10.1007/978-3-319-63001-4
_zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
880 0 _6505-00
_aPart I: History And Conflux -- How Hormones, As Ancient Signalling Molecules, Regulate Diverse Biological Processes Through Evolution -- Somatotropic Axis' Role In Ageing And Longevity Could Depend On Life-History Strategies Of Species -- Part Ii: Growth, Stress And Metabolism -- Glucocorticoid Hormones In Aging -- Zinc, Insulin And Igf-I Interplay In Aging -- Growth Hormone And Igf-1 Axis In Aging And Longevity -- Thyroid Function In Healthy Ageing And Longevity -- Tgf-Β In Development And Ageing -- Part Iii: Neuroendocrine And Rhythms -- Hormones Of Hypothalamus In Aging -- Environmental And Physiological Cues On The Hypothalamus During Aging -- Melatonin In Healthy Aging And Longevity -- Horm ones In Clock Regulation During Ageing -- Part Iv: Brain, Immunity And Cytokinins -- Estrogens In Aging -- Cytokines And Aging -- Plant Hormone Cytokinins For Modulating Human Aging And Age-Related Diseases.
988 _aEBOOK, asignarmaterias, EBSPRINGER_2017
998 _b02/2018
_dz
_e-
_zSI
999 _c96451
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