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008			170819s2017 si a ob 001 0 eng d
020			_a9789811045677 _q(electronic bk.)
020			_a9811045674 _q(electronic bk.)
020			_z9789811045660 _q(hardback : alk. paper)
020			_z9811045666 _q(hardback : alk. paper)
040			_aEBLCP _beng _erda _cEBLCP _dOCLCO _dN$T _dMMU _dOCLCO _dYDX _dN$T _dGW5XE _dUAB _dAZU _dUPM _dMERER _dCASUM _dOCLCQ _dESU _dIOG _dCOO _dOCLCO _dJG0 _dOCLCO _dOCLCA _dES-MaUEC _bspa
050		4	_aQH601 _b2017 EB
245	0	0	_aOrganelle contact sites : _bfrom molecular mechanism to disease _cMitsuo Tagaya, Thomas Simmen, editors.
264		1	_aSingapore _bSpringer International Publishing _c2017
264		4	_c2017
300			_a1 recurso en línea (viii, 257 páginas) _bilustraciones (algunas a color)
336			_astill image _bsti _2rdacontent
336			_aTexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_atext file _bPDF
490	0		_aAdvances in experimental medicine and biology _x2214-8019 _vvolume 997
500			_a
504			_aIncluye referencias bibliográficas e índice
505	0		_aOrganelle communication at membrane contact sites (MCS): from curiosity to center stage in cell biology and biomedical research / Thomas Simmen, Mitsuo Tagaya -- Over six decades of discovery and characterization of the architecture at mitochondria-associated membranes (MAMS) / Maria Sol Herrera-Cruz, Thomas Simmen -- Regulation of mitochondrial dynamics and autophagy by the mitochondria-associated membrane / Mitsuo Tagaya, Kohei Arasaki -- Endoplasmic reticulum-mitochondria communication through Ca2+ signaling: the importance of mitochondria-associated membranes (MAMS) / Saverio Marchi, Mart Bittremieux, Sonia Missiroli, Claudia Morganti, Simone Patergnani [and others] -- Ceramide transport from the endoplasmic reticulum to the trans Golgi region at organelle membrane contact sites / Kentaro Hanada -- Endoplasmic reticulum-plasma membrane crosstalk mediated by the extended synaptotagmins / Yasunori Saheki -- Endoplasmic reticulum-plasma membrane contacts regulate cellular excitability / Eamonn J. Dickson -- The lipid droplet and the endoplasmic reticulum / Yuki Ohsaki, Kamil Sołtysik, Toyoshi Fujimoto -- Role of intra- and inter-mitochondrial membrane contact sites in yeast phospholipid biogenesis / Yasushi Tamura, Toshiya Endo -- Discovery and roles of ER-endolysosomal contact sites in disease / William Mike Henne -- Alzheimer disease / Estela Area-Gomez, Eric A. Schon -- Mitochondrial-associated membranes in Parkinson's disease / Nobutaka Hattori, Taku Arano, Taku Hatano, Akio Mori, Yuzuru Imai -- Role of endoplasmic reticulum-mitochondria communication in type 2 diabetes / Jennifer Rieusset -- Mitochondrial-endoplasmic reticulum contact sites mediate innate immune responses / Takuma Misawa, Michihiro Takahama, Tatsuya Saitoh -- Hepatitis C virus replication / Tetsuro Suzuki -- Hijacking of membrane contact sites by intracellular bacterial pathogens / Isabelle Derré -- Alterations in Ca2+ signalling via ER-mitochondria contact site remodelling in cancer / Martijn Kerkhofs, Carlotta Giorgi, Saverio Marchi, Bruno Seitaj, Jan B. Parys [and others].
520	3		_a"This book provides the first comprehensive coverage of the quickly evolving research field of membrane contact sites (MCS). A total of 16 chapters explain their organization and role and unveil the significance of MCS for various diseases. MCS, the intracellular structures where organellar membranes come in close contact with one another, mediate the exchange of proteins, lipids, and ions. Via these functions, MCS are critical for the survival and the growth of the cell. Owing to that central role in the functioning of cells, MCS dysfunctions lead to important defects of human physiology, influence viral and bacterial infection, and cause disease such as inflammation, type II diabetes, neurodegenerative disorders, and cancer. To approach such a multifaceted topic, this volume assembles a series of chapters dealing with the full array of research about MCS and their respective roles for diseases. Most chapters also introduce the history and the state of the art of MCS research, which will initiate discussion points for the respective types of MCS for years to come. This work will appeal to all cell biologists as well as researchers on diseases that are impacted by MCS dysfunction. Additionally, it will stimulate graduate students and postdocs who will energize, drive, and develop the research field in the near future"--Publisher's description.
588	0		_aOnline resource; title from PDF title page (EBSCO, viewed August 29, 2017)
988			_aEBOOK, EBSPRINGER_2017
650		7	_2embne _aMembranas celulares _9142266
650		7	_2embne _aCitología _9139477
700	1		_aSimmen, Thomas, _eeditor literario
700	1		_aTagaya, Mitsuo, _d1958- _eeditor literario
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=http://link.springer.com/10.1007/978-981-10-4567-7 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
998			_b02/2018 _dz _e- _zSI