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005			20230102112754.0
006			m o d
007			cr cnu---unuuu
008			170819s2017 xx ob 001 0 eng d
020			_a3319639536 _q(electronic bk.)
020			_a9783319639536 _q(electronic bk.)
020			_z3319639528
020			_z9783319639529
040			_aEBLCP _beng _epn _cEBLCP _dN$T _dYDX _dGW5XE _dOCLCF _dUAB _dAZU _dUPM _dMERER _dOCLCQ _dESU _dIOG _dCOO _dOCLCQ _dES-MaUEC _bspa
050		4	_aQP551 _b2017 EB
100	1		_aJežek, Jan.
245	1	0	_aBiomedical Applications of Acridines : _bDerivatives, Syntheses, Properties and Biological Activities with a Focus on Neurodegenerative Diseases.
264		1	_aCham, Switzerland _bSpringer International Publishing _c2017
300			_a1 recurso en línea (243 páginas)
336			_aTexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_atext file _bPDF
490	0		_aProgress in Drug Research _vv. 72
500			_a
504			_aIncluye referencias bibliográficas e índice
505	0		_aAcknowledgements; Contents; Acronyms; 1 Introduction; References; 2 Nomenclature; References; 3 Syntheses; 3.1 Syntheses of Acridine Ring and Its Precursors; 3.2 Acridine-Peptide Conjugates; 3.3 Acridines as Catalysts; References; 4 Interactions of Acridines with Nucleic Acids; 4.1 DNA; 4.2 DNA Quadruplexes; 4.3 RNA; 4.4 PNA; 4.5 Acridine Metal Complexes; 4.6 Structural Aspects of Nucleic Acid Binding; References; 5 Interactions with Proteins; 5.1 Interactions with Nucleic Acids Processing Proteins; 5.1.1 Topoisomerases; 5.1.2 Transcription Factors; 5.1.3 RecA Protein; 5.1.4 Telomerase.
505	8		_a5.2 Interactions with Other Proteins5.3 Structural Aspects of Acridine Interactions with Proteins; References; 6 Applications for Treatment of Neurodegenerative Diseases; 6.1 Alzheimer's Disease; 6.1.1 Multitargeted Strategy in AD; 6.2 Parkinson's Disease; 6.3 Prion Diseases; 6.4 Other Neurodegenerative Diseases; References; 7 Some Application of Selective Toxicities of Acridines; 7.1 Antiparasitic Drug; 7.2 Cancer Treatment; 7.3 Antibacterial Drugs; 7.4 Antiviral Drugs; References; 8 Pharmacokinetics and Metabolism of Acridine Drugs; References; 9 Acridine on Dendrimeric Carriers.
505	8		_a9.1 Application for Drug and Gene DeliveryReferences; 10 Acridines Used for Staining; References; 11 Miscellaneous; References; 12 Conclusions and Outlook; Index.
520	3		_aThis book describes applications of acridines for the treatment of various neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and various prion diseases, and discusses the potential of acridines in neuro-regenerative medicine. Using modern data-mining software, it presents structures of acridines with nucleic acids and proteins and compares them with the native structures. Furthermore, the book presents modern methods of acridine synthesis, comparing them with the most useful conventional methods. Acridines interact with both nucleic acids and proteins, and due to their direct interactions with various enzymes, they can be suitable for the treatment of neurodegenerative diseases, inflammation, immunological disorders, and protozoal diseases. The characteristic spectral properties of acridines can be employed in labeling proteins, nucleic acids, lipids, and even cells and their compartments. Moreover, they can be applied in photodynamic therapy.
988			_aEBOOK, asignarmaterias, EBSPRINGER_2017
650		7	_aCompuestos orgánicos _xSíntesis _2embne _9187864
700	1		_aHlaváček, Jan.
700	1		_aŠebestík, Jaroslav.
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=http://link.springer.com/10.1007/978-3-319-63953-6 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
998			_b02/2018 _dz _e- _zSI