000			05563cam a2200457Mi 4500
988			_aSpringer_Medicine_2017
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005			20230102112752.0
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007			cr cnu---unuuu
008			170812s2017 xx o 000 0 eng d
020			_a3319574248
020			_a9783319574240 _q(electronic bk.)
020			_z331957423X
020			_z9783319574233
040			_aEBLCP _cEBLCP _dOCLCO _dYDX _dN$T _dGW5XE _dN$T _dDKU _dOCLCF _dUAB _dAZU _dOCLCQ _dUPM _dMERER _dOCLCQ _dESU _dIOG _dCOO _dOCLCO _dES-MaUEC _bspa
050		4	_aRC267 _b2017 EB
100	1		_aHoffman, Robert M., _9676022 _d1944-
245	1	0	_aPatient-Derived Mouse Models of Cancer : _bPatient-Derived Orthotopic Xenografts (PDOX)
264		1	_aCham _bSpringer International Publishing _c2017
300			_a1 recurso en línea (304 páginas)
336			_aTexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_atext file _bPDF
490	0		_aMolecular and Translational Medicine
500			_aSpringerLink
500			_aSurgical Orthotopic Implantation (SOI) of Tumor Fragments
505	0		_aPreface; Contents; List of Contributors; 1: In Memoriam: Jørgen Rygaard Ư (1934-2016), Father of Patient-Derived Mouse Models of Cancer and Modern Cancer Research; Patient-Derived Orthotopic Xenografts (PDOX); Transgenic Nude Mice Expressing Fluorescent Proteins in Almost All Tissues; References; 2: The Revival of Patient-Derived Xenograft Mouse Models of Cancer: Way Back to the Future; References; 3: Patient-Derived Xenograft Models for Human Cancer: The Freiburg Experience; Historical Aspects of PDX; Origin and Properties of Nude Mouse; Morphologic and Physiologic Characteristics.
505	8		_a5: The Effects of the Organ Microenvironment on Metastatic Cell Gene Signatures Introduction; Process of Metastasis; Cross-Species Hybridization of Microarrays for Studies of Metastasis; Experimental Approach; Cancer Type-Specific Gene Signatures; Organ Type-Specific Gene Signatures: Effects of the Organ Microenvironment on Cancer Cell Gene Signatures; Organ and Cancer Type-Specific Gene Signatures; Additional Studies; References; 6: Techniques for Surgical Orthotopic Implantation of Human Tumors to Immunodeficient Mice; Introduction; Early Nude-Mouse Models of Human Cancer.
505	8		_aBevacizumab as an Example of the Development of a Predictive Gene Signature PDX for the Identification of Targeted Therapy, Example: B-raf- Inhibitor Vemurafenib; Outlook; PDX for Anticancer Drug Development; PDX for Patient-Oriented Sensitivity Testing; Summary; References; 4: From Ectopic to Orthotopic Tumor Grafting Sites: Evidence for a Critical Role of the Host Tissue Microenvironment for the Actual Expression of the Malignant Phenotype; An Historical Account; The Popular Subcutaneous Route; The Orthos Way; Comments in Conclusion; References.
505	8		_aEvaluation Parameters for Tumor Response Comparison of Tumor Response; Potential of the Nude Mouse System as a Predictive Assay; Tumor Clonogenic Assay as a 3D Culture System to Preselect Sensitive Models; PDX as a Valuable Model System for Tumor Biology Studies; Combined In Vitro and In Vivo Testing Procedure; In Vitro and In Vivo Evaluation of Anticancer Agents from a German Drug Development Program, the EORTC and the NCI; The Concept of Preclinical In Vivo Phase II Studies; Molecular Characterization of the PDX Panel.
505	8		_aImmunological Properties Early Freiburg Experience in the Establishment, Characterization, and Therapeutic Use of PDX from 1978 Until 1988; Take Rate, Growth Behavior, and Drug Response from 1979 Until 1988; PDX Take/Growth as a Prognostic Factor for Survival of Cancer Patients; PDX Regrowth After Being Frozen in Liquid Nitrogen; Similarities and Changes of PDX Compared to the Donor Tumor; Tumor Models Available in 1991; Comparison of Drug Response of the Tumor Growing in the Nude Mouse and in the Patient; Experimental Design of Testing; Chemotherapy.
520	3		_aThis text highlights seminal discoveries and also provides comprehensive and state-of the-art approach to mouse models of human patient tumors. These areas include training, basic techniques, as well as general troubleshooting. Subsequent chapters focus on the different mouse models of patient tumors including the various strains of immunodeficient mice currently available and the transplantation techniques that can be used as well as state-of-the-art imaging techniques. Practical applications of the models from drug discovery, genome analysis to personalized treatment are also covered. Written by experts in that field, each of these sections address these critical issues. A brief review of the existing literature addressing the particular topic follows in each section. Presently, there is no single source to provide information on technique and uses of mouse models of human patient tumors. Patient-Derived Mouse Models of Cancer will satisfy this need for cancer researchers, oncologists, pharmaceutical and biotechnology industry scientists as well as molecular biologists studying in vivo systems.
650		7	_aCáncer _xInvestigación _2embne _9182523
650		7	_aTrasplante de órganos _2embne _9140365
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=http://link.springer.com/10.1007/978-3-319-57424-0 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
998			_b02/2018 _dz _e- _zSI