000			03699cam a2200421M 4500
988			_aSpringer_Medicine_2017
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008			170809s2017 sz o 001 0 eng d
020			_a331939147X _q(electronic bk.)
020			_a9783319391472 _q(electronic bk.)
020			_z3319391453
020			_z9783319391458
040			_aYDX _cYDX _dN$T _dEBLCP _dGW5XE _dN$T _dDKU _dOCLCF _dUAB _dAZU _dUPM _dMERER _dOCLCQ _dESU _dIOG _dCOO _dES-MaUEC _bspa
050		4	_aRC270.3.T84 _b2017 EB
066			_c(S
245	0	0	_aBiomarkers of the tumor microenvironment : _bbasic studies and practical applications _cLars A. Akslen, Randolph S. Watnick, editors.
264		1	_aCham _bSpringer _c2017.
300			_a1 recurso en línea
336			_aTexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_atext file _bPDF
500			_aIncluye índice
500			_aSpringerLink
505	0		_aMarkers of tumor-vascular interactions -- Extracellular matrix, especially integrins, importance for tumor progression -- Role of Axl for epithelial-mesenchymal transition and tumor spread -- Models of tumour progression in prostate cancer -- Biomarkers of tumor progression in malignant melanoma -- Biomarker signatures and tumor progress in breast cancer -- Biomarker panels and contemporary practice in clinical trials of targeted treatment -- Role of prosaposin in niche regulation and metastatic spread -- Regulators of microenvironment and metastases in prostate cancer -- Semaphorins and angiogenesis -- Heterogeneity of angiogenesis phenotypes -- Biology of metastatic niches -- Lymphangiogenesis and tumor progress -- Extracellular matrix -- Paracrine signalling and tumor progress -- Cancer associated fibroblasts -- Tumor immunology -- Interleukins and inflammatory programs in tumor progress -- Global gene expression signatures of the tumor microenvironment -- Microarray analysis of the tumour microenvironment -- Studies of the tumor microenvironment.
520	3		_aThis book reviews different aspects of the cancer microenvironment, and its regulation and importance for tumor progression. Practical applications, in terms of how biomarkers are increasingly included in therapy protocols, will also be discussed. Biomarkers of the Tumour Microenvironment: Basic Studies and Practical Applications is aimed at research pathologists in the cancer field, and also cancer researchers from other backgrounds, especially those using morphology techniques and models focusing on cross-talk between different cell types in tumors.
650		7	_aMarcadores biológicos _2embne _9162047
700	1		_aAkslen, Lars A.
700	1		_aWatnick, Randolph S.
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=http://link.springer.com/10.1007/978-3-319-39147-2 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
880	0		_6505-00/(S _aForeword; Preface; The Tumor Microenvironment: A Prologue; Contents; Part I: Basic Mechanisms and Biomarkers; Chapter 1: The Role of the Tumor Microenvironment in Regulating Angiogenesis; Introduction; Cell Signaling Mechanisms and Factors Influencing Stromal Angiogenesis; VEGF; Basic Fibroblast Growth Factor (bFGF); TGF-β; PDGF; Hormones and Nuclear Receptors; Matrix Metalloproteases; Thrombospondin-1; Nonprotein Mediators of Angiogenesis; Carcinoma-Associated Fibroblasts; Bone Marrow-Derived Cells; Macrophages; Mast Cells; Mesenchymal Stem Cells; Neutrophils; Conclusion
942			_2lcc _cLE
998			_b02/2018 _dz _e- _zSI