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| 008 | 170809s2017 sz o 000 0 eng d | ||
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_a3319603248 _qelectronic bk. |
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| 020 |
_a9783319603247 _qelectronic bk. |
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| 020 | _z9783319603230 | ||
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| 066 | _c(S | ||
| 050 | 4 |
_aRC700.D5 _b2017 EB |
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| 245 | 0 | 0 | _aMechanisms of vascular defects in diabetes mellitus. |
| 264 | 1 |
_aCham _bSpringer _c2017. |
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| 300 | _a1 recurso en línea | ||
| 336 |
_aTexto _btxt _2rdacontent |
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| 337 |
_aelectrónico _bc _2rdamedia |
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| 338 |
_arecurso electrónico _bcr _2rdacarrier |
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| 347 |
_atext file _bPDF |
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| 490 | 0 |
_aAdvances in biochemistry in health and disease _vv. 17 |
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| 500 |
_aSpringerLink _bSpringer Biomedical and Life Sciences eBooks 2017 English+International |
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| 505 | 0 | _aPreface; Contents; Contributors; About the Editors; Part I: Introduction; Chapter 1: The Global Burden of Diabetes and Its Vascular Complications; 1.1 Introduction; 1.2 Global Burden of Diabetes; 1.3 Vascular Complications; 1.3.1 Microvascular Complications; 1.3.1.1 Diabetic Retinopathy (DR); 1.3.1.2 Diabetic Nephropathy; 1.3.1.3 Diabetic Neuropathy; 1.3.2 Macrovascular Complications; 1.3.2.1 Cardiovascular Disease; 1.3.2.2 Peripheral Vascular Disease; 1.3.2.3 Cerebrovascular Disease; 1.3.3 Overlap Between Micro and Macrovascular Complications | |
| 505 | 8 | _a1.4 Mortality Due to Diabetes Associated Complications1.5 Conclusions and the Way Forward; References; Part II: Pathogenesis; Chapter 2: Genetic Basis for Increased Risk for Vascular Diseases in Diabetes; 2.1 Introduction; 2.2 Clinical Presentations of Type 2 Diabetes; 2.3 Vascular Diseases; 2.3.1 Microvascular Diseases; 2.3.2 Macrovascular Diseases; 2.4 Pathophysiology of Diabetic Complications; 2.5 Risk Assessment in the Diabetic Patient; 2.6 Risk Factors for Development of Diabetic Vascular Complications; 2.6.1 Insulin Resistance; 2.6.2 Atherogenic Dyslipidemia; 2.6.3 Hypertension | |
| 505 | 8 | _a2.11.3 GWAS for Coronary Heart Diseases in Type 2 Diabetes2.11.3.1 Insights from GWAS for CHD; 2.12 Epigenetics and Diabetic Complications; 2.13 Conclusions; References; Chapter 3: Vascular Remodeling in Diabetes Mellitus; 3.1 Introduction; 3.2 Overview of Vascular Remodeling; 3.3 Mediators of DM Induce VRM; 3.3.1 Hyperglycemia and Related Metabolic Abnormalities; 3.3.1.1 Polyol and Hexosamine Pathway; 3.3.1.2 Diacyglycerol (DAG); 3.3.2 Advanced Glycation End Products (AGE); 3.3.2.1 Receptor Mediated Mechanisms; 3.3.2.2 Non-receptor Mediated Mechanisms; 3.3.3 Insulin Abnormalities | |
| 505 | 8 | _a3.3.4 Excess Free Fatty Acid Production3.3.5 Increased Angiotensin II and Endothelin-1; 3.3.6 DM Associated Hyperlipidemia and Hypertension; 3.3.7 Abnormal Shear Stress; 3.4 Pathophysiological Mechanisms of Diabetes Induced Vascular Remodeling; 3.4.1 Oxidative Stress and Endothelial Dysfunction; 3.4.2 Endoplasmic Reticulum Stress and Autophagy; 3.4.3 Inflammation; 3.4.4 Vascular Calcification; 3.4.4.1 Mechanisms of Vascular Calcification; 3.4.5 Genetic and Epigenetic Effects on Diabetic VRM; 3.5 Overview of Morphological Changes in DM Induced VRM; 3.5.1 Endothelial Cell Alterations | |
| 520 | 3 | _aThis book comprising 24 chapters is devoted to the mechanisms for the pathogenesis of the spectrum of vascular diseases in diabetes. Cellular events and molecular pathways that regulate the structure and function of both small and large arteries, the dysregulation in these vessels caused by hyperglycemia, oxidative stress, metabolic and haemostatic derangements secondary to diabetes, are discussed. Mechanisms of vascular remodelling and rupture of atherosclerotic plaques in diabetes are also covered. Several of the reviews also discuss therapeutic targets and drugs employed to reduce endothelial dysfunction and vascular inflammation in diabetes. All articles are authored by experts in their respective research fields. This compendium will be of interest to both basic scientists and clinicians in the pursuit of unravelling the molecular basis of vascular diseases and also to those who seek to identify targets for therapy of vascular complications of diabetes. | |
| 650 | 7 |
_aEnfermedades vasculares _2embne _0(OCoLC)fst00892225 _0 _9668848 |
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| 700 | 1 | _aKartha, C. C. | |
| 700 | 1 | _aPillai, Radhakrishna. | |
| 700 | 1 | _aRamachandran, Surya. | |
| 856 | 4 | 0 |
_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=http://link.springer.com/10.1007/978-3-319-60324-7 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid) |
| 880 | 8 |
_6505-00/(S _a2.6.4 Elevated Plasma Glucose2.6.5 Inflammatory Mediators; 2.6.6 Homocysteine; 2.7 Approaches to Identify Genetic Factors for Diabetes; 2.8 Genetics of Type 2 Diabetes; 2.8.1 Current Status in Indian Population; 2.9 Link Between CAD and Diabetes; 2.9.1 PPARγ; 2.9.2 TCF7L2; 2.9.3 ACE (Angiotensin 1 Converting Enzyme); 2.9.4 TNF α; 2.9.5 Adiponectin; 2.9.6 IRS1; 2.9.7 Other Genes; 2.10 Genetic Factors for Coronary Heart Diseases in Type 1 Diabetes; 2.11 Genetic Factors for Coronary Heart Diseases in Type 2 Diabetes; 2.11.1 Linkage Studies; 2.11.2 Candidate Gene Studies |
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| 988 | _aEBOOK, asignarmaterias, EBSPRINGER_2017D | ||
| 998 |
_b02/2018 _dz _e- _zSI |
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| 999 |
_c96401 _d96401 _x1 |
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