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007			cr |n|||||||||
008			170728s2017 sz o 000 0 eng d
020			_a3319573632 _q(electronic bk.)
020			_a9783319573632 _q(electronic bk.)
020			_z3319573624
020			_z9783319573625
040			_aYDX _cYDX _dN$T _dEBLCP _dGW5XE _dN$T _dUAB _dESU _dAZU _dUPM _dYDX _dOCLCF _dCOO _dSTF _dOCLCQ _dMERER _dVT2 _dOCLCQ _dIOG _dOCLCO _dJG0 _dOCLCO _dOCLCA _dES-MaUEC _bspa
050		4	_aQM451 _b2017 EB
245	0	0	_aDecoding neural circuit structure and function : _bcellular dissection using genetic model organisms _cArzu Çelik, Mathias F. Wernet, editors.
264		1	_aCham _bSpringer _c2017.
300			_a1 recurso en línea
336			_aTexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_atext file _bPDF
500			_aSpringerLink _bSpringer Biomedical and Life Sciences eBooks 2017 English+International
505	0		_aForeword; We Live in Exciting Times; Contents; Notes from the Editors; Anatomy: High-Resolution Neuroanatomy Using Molecular-Genetic Tools; 1 The Current State of the Neuroanatomy Toolkit in the Fruit Fly Drosophila melanogaster; Abstract; 1.1 Introduction; 1.2 Binary Activation Systems; 1.2.1 The GAL4 System; 1.2.2 The LexA System; 1.2.3 The Q System; 1.3 Neurogenetic Labeling; 1.3.1 Fluorescent Protein Reporters; 1.3.2 Non-fluorescent Protein Reporters; 1.4 Regulating Binary Activators; 1.4.1 Enhancer Trapping and Bashing; 1.4.2 Promoter Bashing and Trapping; 1.4.3 Protein Trapping.
505	8		_a1.5 Refining Genetic Targeting by Intersectional Perturbations1.5.1 OR Gates; 1.5.2 AND Gates; 1.5.3 NOT Gates; 1.5.4 Combinatorial AND/NOT Gating; 1.6 Mitotic Analysis and Multicolor Stochastic Labeling Strategies in D. melanogaster; 1.7 Conclusions and Future Directions; Acknowledgements; References; 2 Retinal Connectomics; Abstract; 2.1 Introduction; 2.2 Some Basic Retinal Anatomy; 2.3 Why Is Retinal Connectomics Difficult?; 2.4 The Long Overdue Automation of Electron Microscopy; 2.5 The Real Bottleneck-Data Analysis; 2.6 A Retinal 'Contactome'
505	8		_a2.7 Correlating Retinal Structure with Function2.8 Species-Dependent Differences in Retinal Wiring; 2.9 Future of Retinal Connectomics; References; 3 Recent Progress in the 3D Reconstruction of Drosophila Neural Circuits; Abstract; 3.1 Introduction; 3.1.1 The Fly CNS as a Model System of Connectomics Study; 3.1.2 Anatomy of the Drosophila CNS; 3.2 Reconstruction of Neuronal Circuits and Analysis Using CLSM Image Data; 3.2.1 Visualizing Neurons with Confocal Laser Microscopy; 3.2.2 Three-Dimensional Reconstruction of Neurons in the Fly Brain.
505	8		_a3.2.2.1 Algorithms for Three-Dimensional Reconstruction3.2.2.2 FluoRender: A Volume Rendering Tool Optimized for CLSM Volume Data; 3.2.3 3D Registration of Brains; 3.2.4 Application of 3D Reconstruction and Registration; 3.2.4.1 Clonal Unit Analysis; 3.2.4.2 Prediction of Synaptic Partners; 3.3 Electron Microscopy-Based Reconstruction and Connectomics; 3.3.1 Ultrastructures Visualized with EM; 3.3.2 Strategies of 3D Reconstruction; 3.3.2.1 Dense (Saturated) Reconstruction/Sparse Reconstruction; 3.3.2.2 Volumetric Reconstruction/Skeletonized Reconstruction.
505	8		_a3.3.2.3 Manual Tracing/Automatic Tracing3.3.3 3D EM Methods in Connectomics Studies of Drosophila CNS; 3.3.3.1 Serial-Section Transmission EM (ssTEM); 3.3.3.2 Serial Block-Face Scanning EM (SBF-SEM); 3.3.3.3 Focused-Ion Beam-Aided Scanning EM (FIB-SEM); 3.3.4 EM Connectomics Studies in the Fly CNS; 3.3.4.1 Connectivity Analysis in the Optic Lobe Neuropils Using ssTEM and FIB-SEM Methods; 3.3.4.2 Imaging the Blowfly Brain with SBF-SEM; 3.3.4.3 Reconstruction of the Larval CNS with ssTEM; 3.3.5 Other Imaging Techniques for Large-Scale Connectomics.
520	3		_aThis book offers representative examples from fly and mouse models to illustrate the ongoing success of the synergistic, state-of-the-art strategy, focusing on the ways it enhances our understanding of sensory processing. The authors focus on sensory systems (vision, olfaction), which are particularly powerful models for probing the development, connectivity, and function of neural circuits, to answer this question: How do individual nerve cells functionally cooperate to guide behavioral responses? Two genetically tractable species, mice and flies, together significantly further our understanding of these processes. Current efforts focus on integrating knowledge gained from three interrelated fields of research: (1) understanding how the fates of different cell types are specified during development, (2) revealing the synaptic connections between identified cell types ("connectomics") using high-resolution three-dimensional circuit anatomy, and (3) causal testing of how iden tified circuit elements contribute to visual perception and behavior.
650		7	_aRedes neuronales artificiales _2embne _0(OCoLC)fst01036245 _0 _9678664
700	1		_aCelik, Arzu.
700	1		_aWernet, Mathias F.
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=http://link.springer.com/10.1007/978-3-319-57363-2 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
988			_aEBOOK, asignarmaterias, EBSPRINGER_2017D
998			_b02/2018 _dz _e- _zSI
999			_c96370 _d96370 _x1