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003			ES-MaUEC
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006			m o d
007			cr |n|||||||||
008			170718s2017 si a ob 000 0 eng d
020			_a9789811031625 _q(electronic bk.)
020			_a9811031622 _q(electronic bk.)
020			_z9789811031618
020			_z9811031614
040			_aYDX _cYDX _dN$T _dGW5XE _dEBLCP _dN$T _dNJR _dYDX _dUAB _dESU _dAZU _dUPM _dIOG _dCOO _dOCLCQ _dMERER _dVT2 _dOCLCQ _dOCLCO _dES-MaUEC _bspa
050		4	_aQP609.P78 _b2017 EB
245	0	0	_aProteases in human diseases _cSajal Chakraborti, Tapati Chakraborti, Naranjan S. Dhalla, editors.
264		1	_aSingapore _bSpringer _c2017.
300			_a1 recurso en línea _bilustraciones (algunas a color)
336			_aTexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_atext file _bPDF
500			_aSpringerLink
504			_aIncluye referencias bibliográficas
505	0		_a1. Matrix metalloproteases in breast carcinoma, immunohistology and prognosis -- 2. Matrix metalloproteases in parasite infection -- 3. Cysteine cathepsins: In health and rheumatoid arthritis -- 4. Protective role of antiproteases in radiation induced damage -- 5. Role of proteases in the regulation of N-myristoyltransferase -- 6. Proteases in cancer: Potential therapeutic targets -- 7. MMPs in oral squamous cell carcinoma -- 8. Caspase regulatory mechanisms: Implications in pathogenesis and therapeutics -- 9. Physiological and pathological functions of mitochondrial proteases -- 10. Proteases of parasitic helminths: their metabolic role in establishment of infection in the host -- 11. Cysteine proteases of parasitic helminths -- 12. targeting proteases in urine for bladder cancer diagnosis -- 13. Intramembrane cleaving proteases (ICLiPs), particularly the gamma secretase protease and its role in neurodegeneration, cancer and innate immune signalling -- 14. Contribution of matrix metalloproteases in cardiovascular diseases -- 15. OPG/RANKL-protease axis in cardiometabolic diseases -- 16. Proteases and protease inhibitors in male reproduction -- 17. The role of MMP-2 and -9 in embryonic neural crest cells and their derivatives -- 18. Proteolytic ubiquitin like proteins -- 19. C.albicans aspartic proteases: role of these enzymes in degradation of crucial human host proteins at the place of infection and a possible implications of the protease action for propagation of infection. -- 20. MMPs in cancer -- 21. Pathophysiological roles played by proteases of Psedomonas aeruginosa: crucial multifunctional molecules involved in the host infection -- 22. Role of proteases on activating cell death pathways -- 23. varying faces of matrix metalloproteinases in cardiovascular diseases -- 24. kallikreins and kallikrein related peptides (KLKs) in health and disease -- 25. Endogenous proteases in tumoral progression.
520	3		_aThis book bridges the gap between fundamental research and biomedical and pharmacological applications on proteases. It represents a comprehensive overview of the multifaceted field of proteases in cellular environment and highlights the recently elucidated functions of complex proteolytic systems in different diseases. Several established investigators have elucidated the crucial role of proteases in biological processes, including how proteolytic function and regulation can be combined to develop new strategies of therapeutic interventions. Proteases form one of the largest and most diverse families of enzymes known. It is now clear that proteases are involved in every aspect of life functions of an organism. Under physiological conditions, proteases are regulated by their endogenous inhibitors; however, when the activity of proteases is not regulated appropriately, disease processes can result in. So, there is absolute need for a stringent control of proteolytic activities in cells and tissues. Dysregulation of proteases may cause derangement of cellular signalling network resulting in different pathophysiological conditions such as vascular remodelling, atherosclerotic plaque progression, ulcer and rheumatoid arthritis, Alzheimer disease, cancer metastasis, tumor progression and inflammation. Additionally, many infective microorganisms require proteases for replication or use proteases as virulence factors, which have facilitated the development of protease-targeted therapies for a variety of parasitic diseases.
988			_aEBOOK, EBSPRINGER_2017D
650		7	_2embne _9146220 _aEnzimas proteolíticas
650		7	_2embne _aProteínas _9139861
700	1		_aChakraborti, Sajal. _984935
700	1		_aChakraborti, Tapati.
700	1		_aDhalla, Naranjan S. _984616
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=http://link.springer.com/10.1007/978-981-10-3162-5 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
998			_b02/2018 _dz _e- _zSI