000			03201cam a2200421Mi 4500
988			_aSpringer_Medicine_2017
999			_c96291 _d96291 _x1
001			96291
003			ES-MaUEC
005			20230102112747.0
006			m o d
007			cr |n|||||||||
008			170704s2017 sz o 001 0 eng d
020			_a3319558250 _q(electronic bk.)
020			_a9783319558257 _q(electronic bk.)
020			_z3319558242
020			_z9783319558240
040			_aYDX _cYDX _dN$T _dEBLCP _dGW5XE _dN$T _dUAB _dAZU _dUPM _dMERER _dESU _dOCLCQ _dCOO _dOCLCQ _dIOG _dOCLCA _dES-MaUEC _bspa
050		4	_aRC267 _b2017 EB
245	0	0	_aPatient-derived xenograft models of human cancer _cYuzhuo Wang, Dong Lin, Peter W. Gout, editors.
264		1	_aCham _bHumana Press _c2017.
300			_a1 recurso en línea
336			_aTexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_atext file _bPDF
490	0		_aMolecular and translational medicine
500			_aIncluye índice
500			_aSpringerLink
505	0		_aIntroduction -- History and Evolution of PDX Cancer Models -- Establishment and Characterization of PDX Models -- Methods of Generating PDX Models -- Fidelity and Stability of PDX Models -- Applications of PDX Models -- Studies of Cancer Heterogeneity -- PDX and Cancer Stem Cells -- Modeling Cancer Metastasis -- Modeling Drug Resistance -- PDX and Biomarker Development -- PDX and Preclinical Drug Screening -- Co-clinical Trials and Personalized Cancer Therapy/Precision Medicine -- Epilogue -- Future Perspective.
520	3		_aThis book provides a comprehensive, state-of-the-art review of PDX cancer models. In separately produced chapters, the history and evolution of PDX models is reviewed, methods of PDX model development are compared in detail, characteristics of available established models are presented, current applications are summarized and new perspectives about use of PDX models are proposed. Each chapter is written by a world-renowned expert who is conducting cutting-edge research in the field. Each of the subsections provide a comprehensive review of existing literature addressing the particular topic followed by a conclusive paragraph detailing future directions. Extensive illustrations make this an interactive text. Patient-Derived Xenograft Models of Human Cancer will serve as a highly useful resource for researchers and clinicians dealing with, or interested in, this important topic. It will provide a concise yet comprehensive summary of the current status of the field that will help guide preclinical and clinical applications as well as stimulate investigative efforts. This book will propagate innovative concepts and prompt the development of ground-breaking technological solutions in this field.
650		7	_2embne _aOncología _9139207
700	1		_aGout, Peter W.
700	1		_aLin, Dong.
700	1		_aWang, Yuzhuo.
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=http://link.springer.com/10.1007/978-3-319-55825-7 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
998			_b02/2018 _dz _e- _zSI