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988			_aSpringer_Medicine_2017
999			_c96287 _d96287 _x1
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005			20230102112747.0
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007			cr |n|||||||||
008			170705s2017 sz o 001 0 eng d
020			_a3319568205 _q(electronic bk.)
020			_a9783319568201 _q(electronic bk.)
020			_z3319568191
020			_z9783319568195
040			_aYDX _cYDX _dN$T _dEBLCP _dGW5XE _dN$T _dUAB _dYDX _dOCLCO _dAZU _dUPM _dOCLCO _dIOG _dOCLCO _dMERER _dESU _dOCLCQ _dCOO _dOCLCQ _dOCLCO _dOCLCA _dES-MaUEC _bspa
050		4	_aRC280 .B7 _b2017 EB
245	0	0	_aAdvances in biology and treatment of glioblastoma _cKumaravel Somasundaram, editor.
264		1	_aCham _bSpringer _c2017
300			_a1 recurso en línea (272 páginas)
336			_aTexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_atext file _bPDF
490	0		_aCurrent cancer research
500			_aIncludes index
500			_aSpringerLink
505	0		_aPreface; Contents; Author Biography; Chapter 1: Maximal Safe Resection in Glioblastoma: Use of Adjuncts; 1.1 Introduction; 1.2 Preoperative Investigations; 1.2.1 Magnetic Resonance Imaging; 1.2.2 Functional MRI; 1.2.3 Magnetoencephalography; 1.2.4 Navigated Transcranial Magnetic Stimulation; 1.2.5 Diffusion Tensor Imaging; 1.2.6 Deformable Anatomic Templates; 1.3 Intraoperative Adjuncts; 1.3.1 Intraoperative Image Guidance Techniques; 1.3.2 5-Aminolevulinic Acid; 1.3.3 Functional Cortical and Subcortical Mapping; 1.3.4 Principles of Direct Electrical Stimulation.
505	8		_a1.3.5 Motor Mapping and Monitoring1.3.5.1 Somatosensory Evoked Potentials; 1.3.5.2 Motor Evoked Potentials; 1.3.5.3 Cortical Stimulation; 1.3.5.4 Subcortical Stimulation; 1.3.6 Language Mapping; 1.3.7 Resection Principles; 1.4 Conclusion; References; Chapter 2: Molecular Pathology of Glioblastoma- An Update; 2.1 Introduction to Adult Diffuse Gliomas and Glioblastoma with Emphasis on Changing Concepts; 2.2 ISN Haarlem Guidelines and Evolution of WHO 2016; 2.3 WHO 2007 Classification Versus 2016 Classification w.r.t Glioblastoma (Table 2.2).
505	8		_a2.4 Glioblastoma: Gross Pathology, Histomorphology and the New Definitions2.4.1 Glioblastoma, IDH-Wild Type; 2.4.2 Glioblastoma, IDH Mutant (Fig. 2.7); 2.5 Molecules That Define Glioblastoma in Detail; 2.5.1 IDH Mutations; 2.5.2 O6-Methyl Guanine DNA Methyl Transferase (MGMT) Gene Promoter Methylation; 2.5.3 ATRX Mutation; 2.5.4 TP53 Mutation; 2.5.5 TERT Promoter Mutation; 2.5.6 Cytogenetic Abnormalities; 2.5.7 EGFR Amplification and Mutation; 2.5.8 PTEN Mutation; 2.5.9 Platelet Derived Growth Factor Receptor Alpha(PDGFRA); 2.5.10 Neurofibromatosis Type 1 Gene (NF1)Inactivation.
505	8		_a2.5.11 Signaling Pathways Altered in Glioblastoma:2.6 Molecular Biology of Recurrence in Glioblastoma Tumors; 2.7 Summary; 2.8 Clinical Trials; 2.9 Need of the Hour; References; Chapter 3: Current Therapies and Future Directions in Treatment of Glioblastoma; 3.1 Introduction; 3.2 Newly Diagnosed Glioblastoma; 3.2.1 Surgical Resection; 3.2.2 First Line Therapy for Newly Diagnosed GBM; 3.3 Recurrent Glioblastoma; 3.4 Glioblastoma in Older Adults; 3.5 Gliomatosis Cerebrii; 3.6 Targeted Agents in Treatment of GBM; 3.6.1 EGFR Inhibitors; 3.6.2 PI3K and mTOR Inhibitors.
505	8		_a3.6.3 VEGF and VEGFR Inhibitors3.7 Biological Agents in Clinical Trials Against Glioblastoma; 3.7.1 Virus-Based Therapies; 3.7.2 Immunotherapies; 3.7.2.1 Immune Checkpoint Inhibitors; 3.7.2.2 Genetically Engineered T-cells; 3.8 Conclusions; References; Chapter 4: Recent Advances for Targeted Therapies in Glioblastoma; 4.1 Recent Advances for Targeted Therapies in Glioblastoma; 4.2 The Cancer Genome Atlas; 4.3 Tumor Protein P53 Signaling Pathway; 4.4 Retinoblastoma (Rb) Pathway; 4.5 Receptor Tyrosine Kinases Pathway; 4.5.1 VEGFR; 4.5.2 EGFR; 4.5.3 PDGFR; 4.5.4 PI3K/AKT/PTEN/mTOR.
520	3		_aThis volume covers the most important areas of glioblastoma - surgical resection, molecular pathology, targeted therapies, cancer stem cells, the role of DNA methylation, targeted sequencing for personalized therapy, animal models and advances in pediatric glioblastoma. Chapter authors are junior and senior investigators, who are well established in their particular areas and include neurosurgeons, neuropathologists, neurooncologists and basic scientists.
650		7	_2embne _9144370 _aGlioma
650		7	_2embne _aSistema nervioso central _xEnfermedades _9188115
700	1		_aSomasundaram, Kumaravel, _eeditor literario
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=http://link.springer.com/10.1007/978-3-319-56820-1 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
998			_b02/2018 _dz _e- _zSI