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020 _a9789811043109
_q(electronic bk.)
020 _a9811043108
_q(electronic bk.)
020 _z9789811043093
_q(hardcover ;
_qalk. paper)
020 _z9811043094
_q(hardcover ;
_qalk. paper)
040 _aN$T
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_bspa
050 4 _aQP623
_b.R533 2017 EB
066 _c(S
245 0 0 _aRNA activation
_cLong-Cheng Li, editor.
264 1 _aSingapore
_bSpringer
_c[2017]
264 4 _c2017
300 _a1 recurso en línea
_bilustraciones (algunas a color)
336 _astill image
_bsti
_2rdacontent
336 _aTexto
_btxt
_2rdacontent
337 _aelectrónico
_bc
_2rdamedia
338 _arecurso electrónico
_bcr
_2rdacarrier
347 _atext file
_bPDF
490 0 _aAdvances in experimental medicine and biology
_x2214-8019
_vvolume 983
500 _aSpringerLink
_bSpringer Biomedical and Life Sciences eBooks 2017 English+International
504 _aIncluye referencias bibliográficas e índice
505 0 _aSmall RNA-guided transcriptional gene activation (rnaa) in mammalian cells / Long-Cheng Li / Exogenous RNAa. Enhancing neuronogenesis and counteracting neuropathogenic gene haploinsufficiencies by RNA gene activation / Antonello Mallamaci -- Target-recognition mechanism and specificity of RNA activation / Huiqing Cao, Xing Meng, Xiaoxia Wang, Zicai Liang -- Promoter-targeted small activating rnas alter nucleosome positioning / Bin Wang, Yunzhang Hu -- Endogenous RNAa. Endogenous miRNAa: miRNA-mediated gene upregulation / Vera Huang -- Mirna-mediated RNA activation in mammalian cells / Ramani Ramchandran, Pradeep Chaluvally-Raghavan -- RNAa induced by tata box-targeting micrornas / Yijun Zhang, Hui Zhang -- miRNA-mediated RNAa by targeting enhancers / Qingping Zou, Ying Liang, Huaibing Luo, Wenqiang Yu -- RNA activation guided by other RNA. specific increase of protein levels by enhancing translation using antisense oligonucleotides targeting upstream open frames / Xue-Hai Liang, Wen Shen, Stanley T. Crooke -- Repurposing CRISPR system for transcriptional activation / Meng Chen, Lei Stanley Qi -- Developing RNAa-based therapeutics. RNA-mediated gene activation: identifying a candidate RNA for preclinical development / David R. Corey -- Treatment of pancreatic cancer by aptamer conjugated C/EBP[alpha]-saRNA / Sorah Yoon, John J. Rossi -- Treatment of liver cancer by C/EBPA saRNA / Xiaoyang Zhao, Jon Voutila, Stephanos Ghobrial, Nagy A. Habib, Vikash Reebye -- Enhancing angiogenesis in mice by VEGF-targeting small activating RNAs / Tiia A. Turunen, Seppo Ylä-Herttuala, Mikko P. Turunen -- Suppression of prostate cancer metastasis by DPYSL3-targeted saRNA / Benyi Li, Changlin Li -- Development of therapeutic dsP21 for cancer treatment / Moo Rim Kang, Gongcheng Li, Tiejun Pan, Jin-Chun Xing, Long-Cheng Li.
520 3 _aThis book offers an essential guide to RNA activation (RNAa), an emerging and fascinating new field. RNAa is a small RNA-guided and Argonaute-dependent gene regulation phenomenon in which promoter-targeted short double-stranded RNAs (dsRNAs) induce target gene expression at the transcriptional level. It occurs primarily in the nucleus and can be mediated by artificially designed short duplex RNAs that target regulatory sequences (e.g., promoters, genes' 3' termini and enhancers) and naturally occurring small RNAs (e.g., miRNAs and C. elegans 22G-RNAs). With contributions from internationally respected RNA experts, this book provides comprehensive coverage of different RNAa mechanisms and a timely update on recent advances in RNAa research, with a focus on developing RNAa-based therapeutics. Special chapters are also devoted to the topics of gene activation induced by antisense oligonucleotides and the CRISPR system. As the first book to cover RNAa, it will be of interest to a wide audience, from scientists in academia and the pharmaceutical industry to clinicians who wish to further explore the biology of RNAa and related phenomena, so as to harness their full potential for use in biotechnology and drug development.
650 7 _9162770
_aExpresión génica
_2fast
_0(OCoLC)fst00939613
_0
700 1 _aLi, Long-Cheng,
_eeditor literario
856 4 0 _uhttps://go.openathens.net/redirector/universidadeuropea.es?url=http://link.springer.com/10.1007/978-981-10-4310-9
_zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
880 0 _6505-00/(S
_a1. Small RNA-guided transcriptional gene activation (RNAa) in mammalian cells -- 2. Enhancing neurogenesis and counteracting neuropathogenic gene haploinsufficiencies by RNA gene activation -- 3. Target-recognition mechanism and specificity of RNA -- 4. Promoter-targeting small activating RNAs alter nucleosome positioning -- 5. Endogenous miRNAa: miRNA-mediated gene upregulation -- 6. miRNA-mediated RNA activation in mammalian cells -- 7. RNAa induced by TATA box-targeting microRNAs -- 8. miRNA-mediated RNAa by targeting enhancers -- 9. Specific increase of protein levels by enhancing translation using antisense oligonucleotides targeting upstream open frames -- 10. Repurposing CRISPR system for transcriptional activation -- 11. RNA-mediated gene activation: identifying a candidate RNA for preclinical development -- 12. Treatment of pancreatic cancer by aptamer conjugated C/EBPα-saRNA -- 13. Treatment of liver cancer by C/EBPA saRNA -- 14. Enhancing angiogeneis in mice by VEGF-targeting small activating RNAs -- 15. Suppression of prostate cancer metastasis by DPYSL3-targeted saRNA -- 16. Development of therapeutic dsP21-322 for cancer treatment -- Index.
988 _aEBOOK, asignarmaterias, EBSPRINGER_2017D
998 _b02/2018
_dz
_e-
_zSI
999 _c96250
_d96250
_x1