000			03365cam a2200385Ii 4500
001			96180
003			ES-MaUEC
005			20230102112742.0
006			m o d
007			cr cnu|||unuuu
008			170615s2017 gw a ob 000 0 eng d
020			_a3658186232 _q(electronic bk.)
020			_a9783658186234 _q(electronic bk.)
020			_z3658186224
020			_z9783658186227 _q(print)
040			_aGW5XE _cGW5XE _dN$T _dYDX _dOCLCF _dUAB _dAZU _dUPM _dMERER _dESU _dOCLCQ _dCOO _dOCLCQ _dIOG _dES-MaUEC _bspa
050		4	_aQP171 _b.D366 2017 EB
100	1		_aDannheisig, David, _eautor
245	1	0	_aImpact of survivin acetylation on its biological function _cDavid Dannheisig.
264		1	_aWiesbaden, Germany _bSpringer Spektrum _c2017.
300			_a1 recurso en línea (xxiii, 104 páginas) _bilustraciones (algunas a color)
336			_aTexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_atext file _bPDF
490	0		_aBestMasters
500			_aSpringerLink _bSpringer Biomedical and Life Sciences eBooks 2017 English+International
504			_aIncluye referencias bibliográficas
505	0		_aApoptosis -- The Programmed Suicide -- Cancer -- The Enemy Inside -- Nucleocytoplasmic Transport- Cellular Navigation -- Biological Function of Survivin -- Protein modification -- Make-Up for Proteins -- Cell cycle -- Virchow's Heritage.
520	3		_aIn his research, David Dannheisig investigates the influence of lysine129 acetylation on the biological function of survivin including alteration of nucleocytoplasmic shuttling as well as dimerization behavior. Since survivin participates in two major hallmarks of oncogenesis, namely cell death inhibition and chromosomal segregation during the cell cycle, it reflects a valuable target in cancer therapy and research. The author establishes proximity-dependent, fluorescence-microscopic methods to quantify the interaction of survivin with the export receptor Crm1 as well as the homodimerization itself. In the future, those systems can be used to examine the feasible effect of chemical modulators which are targeting these interactions in a cellular background. The outcome achieved is an essential step towards the enhancement of potential cancer therapies. Contents Apoptosis - The Programmed Suicide Cancer - The Enemy Inside Nucleocytoplasmic Transport- Cellular Navigation Biological Function of Survivin Protein modification - Make-Up for Proteins Cell cycle - Virchow's Heritage Target Groups Lecturers, students and researchers in the biological-medical sector Practitioners in the fields of molecular biology, cell biology, fluorescence microscopy, medical biology, protein interaction studies The Author David Dannheisig currently is a student of the International Graduate School in Molecular Medicine (IGradU) pursuing his PhD (Dr. rer. nat) degree at the Institute of Biochemistry and Molecular Biology (iBMB) at Ulm University, Germany.
650		7	_aAcetileno _2embne _0(OCoLC)fst00795601 _0 _9677516
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=http://link.springer.com/10.1007/978-3-658-18623-4 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
988			_aEBOOK, asignarmaterias, EBSPRINGER_2017D
998			_b02/2018 _dz _e- _zSI
999			_c96180 _d96180 _x1