000			04847cam a2200421Ki 4500
988			_aSpringer_Medicine_2017
999			_c96078 _d96078 _x1
001			96078
003			ES-MaUEC
005			20230102112737.0
006			m o d
007			cr |n|||||||||
008			170530s2017 gw ob 001 0 eng d
020			_a3662541815 _q(electronic bk.)
020			_a9783662541814 _q(electronic bk.)
020			_z3662541807
020			_z9783662541807
040			_aYDX _cYDX _dN$T _dGW5XE _dEBLCP _dN$T _dYDX _dOCLCO _dUAB _dESU _dAZU _dUPM _dOCLCO _dIOG _dOCLCO _dCOO _dMERER _dOCLCO _dOCLCQ _dAUD _dOCLCO _dU3W _dES-MaUEC _bspa
050		4	_aRD732 _b2017 EB
245	0	0	_aBio-orthopaedics : _ba new approach _cAlberto Gobbi [and others], editors.
264		1	_aBerlin _bSpringer _c2017
300			_a1 recurso en línea
336			_aTexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_atext file _bPDF
500			_aSpringerLink
504			_aIncluye referencias bibliográficas e índice
505	0		_aForeword; Acknowledgments; Introductory Commentary; References; Contents; Part I: Overview; 1: The Optimization of Natural Healing; 1.1 Introduction; 1.2 The Phases of Tissue Healing; 1.2.1 Hemostasis Phase; 1.2.2 Inflammation Phase; 1.2.3 Proliferation Phase; 1.2.4 Remodeling Phase; 1.3 Impaired Tissue Healing; 1.4 Factors That Contribute to Impaired Healing; 1.4.1 Obesity; 1.4.2 Drugs; 1.5 Factors That Improve Natural Healing; 1.5.1 Sleep; 1.5.2 Circadian Rhythms; 1.5.3 Nutrition; 1.5.4 Dietary Supplements; 1.5.5 Physical Activity; 1.5.6 Cognitive Control/Biofeedback.
505	8		_a4.2.1 The Food and Drug Administration4.2.2 Regulatory Overview; 4.2.3 The Three-Tiered Approach; 4.2.4 Alternative Pathways; 4.2.5 Case Example of Carticel®; 4.3 Regulation of Orthobiologics Around the World; 4.3.1 Europe; 4.3.2 Australia; 4.3.3 Canada; 4.3.4 Russia; 4.3.5 India; 4.3.6 Mexico; 4.3.7 China; 4.3.8 Japan; 4.4 Stem Cell Tourism; 4.4.1 A Direct-to-Consumer Industry; 4.4.2 Domestic Tourism; 4.4.3 Dubious Practices; 4.5 The REGROW Act; 4.6 Reimbursement; 4.6.1 Coverage and Reimbursement in the United States; 4.6.2 Reimbursement of Orthobiologics in the EU.
505	8		_a4.7 Conclusion4.8 Cell Therapy Regulatory Toolkit; References; 5: Tissue Engineering and New Biomaterials; 5.1 Native Extracellular Matrix as a Host; 5.2 Humoral Response to a Scaffold; 5.2.1 Blood Material Interaction and Biofilm Formation; 5.2.2 Acute Inflammation; 5.2.3 Chronic Inflammation; 5.2.4 Granulation Tissue Formation, Foreign Body Reaction, and Tissue Encapsulation; 5.3 Signaling; References; 6: Physiology and Homeostasis of Musculoskeletal Structures, Injury Response, Healing Process, and Regenerative Medicine Approaches; 6.1 Introduction.
505	8		_a6.2 Physiology and Homeostasis of Musculoskeletal Structures6.2.1 Tendon; 6.2.2 Ligament; 6.2.3 Bone; 6.2.4 Skeletal Muscle; 6.2.5 Articular Cartilage and Fibrocartilage; 6.3 Injury Response, Healing Process, and Subsequent Diseases; 6.3.1 Biomarkers; 6.3.2 Osteoarthritis; 6.4 Regenerative Medicine Approaches; 6.4.1 Autologous Biologic Therapies; 6.4.2 Gene Therapy; 6.4.3 Stem Cells; 6.4.4 Tissue Engineering; 6.4.5 Anti-fibrotic therapy; 6.5 Conclusions and Future Directions; References.
520	3		_aThis book introduces the exciting field of orthobiology, which will usher in a new array of therapeutic approaches that stimulate the body's natural resources to regenerate musculoskeletal tissues damaged by trauma or disease. The book addresses a range of key topics and discusses emerging approaches that promise to offer effective alternatives to traditional treatments for injuries to bone, cartilage, muscles, ligaments, and tendons. It explains in detail how a variety of innovative products, including biomaterials, growth factors, and autogenous cells, together provide the basis for the regeneration of these musculoskeletal structures and how recent scientific progress has created unique opportunities to address pathological situations that until recently have been treated with unsatisfactory results. The authors are experts from across the world who come together to provide a truly global overview. The book is published in collaboration with ISAKOS. It will be invaluable for all with an interest in this area of medicine, which has already attained huge popularity in Orthopaedics and Sports Medicine and has also attracted the attention of the lay public.
650		7	_2embne _aCirugía ortopédica _9675145
700	1		_aGobbi, Alberto. _988921
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=http://link.springer.com/10.1007/978-3-662-54181-4 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
998			_b02/2018 _dz _e- _zSI