000			05040cam a2200433Ki 4500
001			96075
003			ES-MaUEC
005			20230102112737.0
006			m o d
007			cr |n|||||||||
008			170530s2017 sz ob 000 0 eng d
020			_a3319527150 _q(electronic bk.)
020			_a9783319527154 _q(electronic bk.)
020			_z3319527142
020			_z9783319527147
040			_aYDX _cYDX _dN$T _dGW5XE _dEBLCP _dN$T _dYDX _dOCLCO _dUAB _dAZU _dESU _dOCLCF _dOCLCO _dIOG _dOCLCO _dCOO _dMIA _dOCLCO _dSTF _dOCLCO _dMERER _dOCLCO _dVT2 _dOCLCQ _dAUD _dOCLCO _dU3W _dES-MaUEC _bspa
050		4	_aQR74.8 _bT446 2017 EB
245	0	4	_aThe molecular biology of photorhabdus bacteria _cRichard H. Ffrench-Constant, editor.
264		1	_aCham _bSpringer _c2017.
300			_a1 recurso en línea
336			_astill image _bsti _2rdacontent
336			_aTexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_atext file _bPDF
490	0		_aCurrent topics in microbiology and immunology _vv. 402
500			_aSpringerLink _bSpringer Biomedical and Life Sciences eBooks 2017 English+International
504			_aIncluye referencias bibliográficas
505	0		_aPreface; Photorhabdus as a Bug for All Seasons; Bugs that Kill Bugs; Bugs that do Drugs; Bugs that Infect Both Insects and Man; Bugs that Just Keep Giving; Contents; Insecticidal Toxins and Virulence Regulation; 55 Insecticidal Toxin Complexes from Photorhabdus luminescens; Abstract; 1 Introduction; 1.1 The Life Cycle of Insecticidal Nematodes; 1.2 Specificity of Insecticidal Toxins; 2 'Toxin Complex' (Tc) Toxins; 2.1 Nomenclature of Tc Toxins; 2.2 TcA-like Proteins of the Toxin Complex; 2.2.1 Interaction of TcA-like Proteins with the Host Cell Membrane
505	8		_a2.2.2 The Molecular and Atomic Structure of TcA-like Proteins2.2.3 Is TcA per se Insecticidal?; 2.3 TcB-like Proteins of the Toxin Complex; 2.4 TcC-like Proteins of the Toxin Complex; 2.5 Structure of the Complete TC Complex; 3 Biological Activities of Tc Toxins; 3.1 TccC3 Is an ADP-Ribosyltransferase that Targets Actin; 3.1.1 Modification of Actin by TccC3 at Threonine148; 3.1.2 Photorhabdus Toxin Photox Modifies Actin at Arginine177; 3.2 TccC5 Is an ADP-Ribosyltransferase that Targets Rho Proteins; 3.2.1 Rho Proteins Are Substrates of TccC5
505	8		_a3.2.2 Functional Consequences of Rho ADP-Ribosylation by TccC54 Conclusions; References; 51 Identifying Anti-host Effectors in Photorhabdus; Abstract; 1 Introduction; 2 A Forward Genetics Approach; 2.1 Rapid Virulence Annotation; 2.2 Secondary Metabolites as Virulence Factors; 2.3 Host Specificity; 3 The Drosophila Embryo System; 4 Immune Cell Phenotype Screen; 5 In Silico Screens; 5.1 Photox-A Toxin Unique to P. luminescens; 5.2 PaTox-A Toxin Unique to P. asymbiotica; 5.3 The Photorhabdus Virulence Cassettes; 6 Future Approaches; References
505	8		_a53 Flagellar Regulation and Virulence in the Entomopathogenic Bacteria-Xenorhabdus nematophila and Photorhabdus luminescensAbstract; 1 Bacterial Motility and Virulence in Pathogenic Bacteria; 2 Flagella Affect Virulence by Facilitating Motility; 3 Flagellar Regulators Affect Virulence by Regulating Non-flagellar Virulence Factors; 4 The Flagella Apparatus as Virulence Factor Secretion System; 5 In Situ Flagellar Gene Expression During Invertebrate Infection; 6 Phenotypic Variation and Bimodal Expression of Flagellar and Virulence Genes; 7 Conclusions and Future Work on P. luminescens
520	3		_aThis book provides an essential update on the startling array of novel insecticidal toxins and drugs produced by the fascinating bacterium Photorhabdus. The respective chapters describe everything from the detailed molecular biology of the 'Toxin complexes' or Tc's to the complexity of insect immune response in relation to both the bacterium and its nematode vector. The volume covers both primary (toxin production and regulation) and secondary (natural product synthesis and regulation) metabolism and emphasises the potential use of toxins and drugs in both agriculture and medicine. It also discusses in detail two totally novel quorum sensing mechanisms and the likely role of LuxR solos in sensing the presence of different bacterial hosts. Lastly, the book explores the unique case of P. asymbiotica, which seems to have evolved the ability to infect both insects and humans. This synthesis proves that Photorhabdus truly does offer a 'gold mine' for the discovery of novel insecticidal proteins and novel natural products with potential uses in agriculture and medicine alike.
650		7	_aInsectos _2embne _0(OCoLC)fst00973988 _0 _9137904
700	1		_aFfrench-Constant, Richard H.
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=http://link.springer.com/10.1007/978-3-319-52715-4 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
988			_aEBOOK, asignarmaterias, EBSPRINGER_2017D
998			_b02/2018 _dz _e- _zSI
999			_c96075 _d96075 _x1