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007			cr cnu|||unuuu
008			170526s2017 sz ob 000 0 eng d
020			_a3319536575
020			_a3319536591 _q(electronic bk.)
020			_a9783319536576
020			_a9783319536590 _q(electronic bk.)
020			_z9783319536576 _q(print)
040			_aN$T _cN$T _dEBLCP _dGW5XE _dN$T _dYDX _dUAB _dESU _dAZU _dUPM _dOCLCF _dIOG _dCOO _dMERER _dVT2 _dOCLCQ _dU3W _dES-MaUEC _bspa
050		4	_aRC268.5 _bM434 2017 EB
066			_c(S
245	0	0	_aMechanisms of molecular carcinogenesis. _nVolume 1 _cJohannes Haybaeck, editor.
264		1	_aCham, Switzerland _bSpringer _c2017.
300			_a1 recurso en línea
336			_aTexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_atext file _bPDF
500			_aSpringerLink _bSpringer Biomedical and Life Sciences eBooks 2017 English+International
504			_aIncluye referencias bibliográficas
505	0		_6880-01 _aPreface; Contents; 1: The Endocannabinoid System in Carcinogenesis; 1.1 The Endocannabinoid System and Its Components; 1.2 The Endocannabinoid System and Cancer; 1.3 Receptors of the Endocannabinoid System Involved in Carcinogenesis; 1.4 Mechanisms of Anti-tumorigenic Effects by Cannabinoids/Endocannabinoids; 1.4.1 Apoptosis; 1.4.2 Autophagy; 1.4.3 Cell Proliferation and Cell Cycle Arrest; 1.4.4 Metastasis; 1.5 Anti-tumorigenic Effects of Cannabinoids/Endocannabinoids: Non-CB Receptor-Mediated; 1.6 Potential Pro-tumorigenic Effects of the Endocannabinoid System; 1.7 Synopsis.
505	8		_a2.3.1 MACC1 as Cancer Inducer2.3.2 MACC1 as Prognostic Marker; 2.3.3 MACC1 as Predictive Marker; 2.3.4 MACC1 as Druggable Target; 2.4 Outlook; References; 3: Axl and Its Mediated Signaling Axis in Cancer; 3.1 Axl Structure, Stimuli, and Expression; 3.1.1 Discovery and Structure of Axl; 3.1.2 Activation of Axl Signaling; 3.1.3 Axl Is Upregulated in Cancer; 3.2 Axl-Mediated Hallmarks of Cancer; 3.2.1 Axl Signaling in Cell Proliferation; 3.2.2 Antiapoptotic Functions of Axl Signaling; 3.2.3 Axl Signaling Induces Angiogenesis.
505	8		_a3.2.4 Axl Signaling Induces Epithelial-Mesenchymal Transition3.2.5 Axl Signaling in Cancer Metastasis; 3.2.6 Axl in Cancer Stemness; 3.3 Axl as Regulator of Drug Resistance in Cancer; References; 4: Insulin Signaling Linking Metabolism and Malignancy; 4.1 Introduction; 4.2 IGF1 in Cancer; 4.3 IGF2 in Cancer; 4.4 Insulin and IGF Signaling and Its Implication in Carcinogenesis; 4.4.1 Insulin Receptors, IGF Receptors, and Hybrid Receptors; 4.4.2 Insulin Receptor Substrates; 4.4.3 PI3K-Related Signaling; 4.4.4 MAPK-Related Signaling; References.
520	3		_aDivided into two volumes the work offers a so far unmatched broad and at the same time deep knowledge on molecular and cellular mechanisms of carcinogenesis and offers comprehensive insight into clinical, therapeutic and technological aspects. This 1st Volume presents tumor entities of the ocular system, the thyroid organ, the oesophagus, gliomas, non-glial brain tumors, head and neck as well as lung cancer. In addition it also discusses in-depth potential novel molecular players and the role of stem cells as well as the endocannabinoid system in carcinogenesis, it furthermore explains tumor metabolism components and signaling pathways. Each of the chapters discusses potential therapeutic strategies and novel drug targets. The book addresses basic scientists and medical researchers interested in translational cancer research.
650		7	_aCarcinogénesis _xMolecular aspects. _2embne _0(OCoLC)fst00846978 _0comprobar BNE19923478372 _9146492
700	1		_aHaybaeck, Johannes, _eeditor literario
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=http://link.springer.com/10.1007/978-3-319-53659-0 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
880	8		_6505-00/(S _a6.7 NF-κB and Its Critical Role for Liver Homeostasis.
880	8		_6505-01/(S _a5: Translational Control and mTOR in Cancer5.1 mTOR Signaling; 5.2 Eukaryotic Translation Initiation Factors (eIFs) in Cancer; 5.3 Targeting the mTOR Pathway in Glioblastoma; 5.4 mTOR Targeting in Colorectal Cancer; References; 6: NF-κB and Its Implication in Liver Health and Cancer Development; 6.1 Introduction; 6.2 Members of the NF-κB/Rel Family; 6.3 The Negative Controllers of NF-κB: IκBs; 6.4 The Canonical NF-κB Pathway; 6.5 The Noncanonical or Alternative NF-κB Pathway; 6.6 NF-κB-Associated Human Diseases and Genetic Mouse Models.
988			_aEBOOK, asignarmaterias, EBSPRINGER_2017D
998			_b02/2018 _dz _e- _zSI
999			_c96066 _d96066 _x1