000			03231cam a2200433Ii 4500
999			_c96061 _d96061
001			96061
003			ES-MaUEC
005			20230102112736.0
006			m o d
007			cr cnu|||unuuu
008			170525s2017 sz ob 001 0 eng d
020			_a3319534556
020			_a3319534572 _q(electronic bk.)
020			_a9783319534558
020			_a9783319534572 _q(electronic bk.)
020			_z9783319534558
040			_aN$T _cN$T _dEBLCP _dN$T _dGW5XE _dYDX _dUAB _dESU _dAZU _dUPM _dOCLCO _dIOG _dCOO _dVT2 _dOCLCQ _dJG0 _dOCLCO _dU3W _dOCLCA _dES-MaUEC _bspa
050		4	_aRB155.8 _b2017 EB
245	0	0	_aSafety and efficacy of gene-based therapeutics for inherited disorders _cNicola Brunetti-Pierri, editor.
264		1	_aCham, Switzerland _bSpringer _c[2017]
264		4	_c2017
300			_a1 recurso en línea
336			_aTexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_atext file _bPDF
500			_aSpringerLink
504			_aIncluye referencias bibliográficas e índice
505	0		_aOverview: gene transfer strategies, principles, applications -- Manufacturing viral gene therapy vectors: general approaches and challenges -- Retrovirus- and lentivirus-based vectors -- Preclinical and clinical applications of retroviral vectors -- Preclinical and clinical applications of lentiviral vectors -- Retrovirus and lentivirus integration -- Adenovirus-based vectors for gene therapy -- Adenoviral vector-host interactions -- Helper-dependent adenoviral vectors -- Gene therapy for cancer treatment -- Oncolytic adenoviruses for cancer treatment -- Vaccination by gene transfer vectors -- AAV vectors: general features and applications -- Adaptive immune response to viral vector delivery -- Herpes viruses: general features and applications -- RNA interference-based strategy for treatment of human diseases -- Antisense oligonucleotide based therapeutics -- Gene editing strategies -- Nonviral vectors.
520	3		_aIn this book, leading international experts analyze state-of-the-art advances in gene transfer vectors for applications in inherited disorders and also examine the toxicity profiles of these methods. The authors discuss the strengths and weaknesses of available vectors in the clinical setting, and specifically focus on the challenges and possible solutions that researchers are testing in order to improve the safety of gene therapy for genetic diseases. This comprehensive and authoritative overview of vector development is a necessary text for researchers, toxicologists, pharmacologists, molecular biologists, physicians, and students in these fields.
588	0		_aOnline resource; title from PDF title page (EBSCO, viewed June 6, 2017).
988			_aEBOOK, EBSPRINGER_2017D
650		7	_2embne _aAnomalías cromosómicas _9677625
650		7	_2embne _aGenética médica _9144879
700	1		_aBrunetti-Pierri, Nicola, _eeditor literario
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=http://link.springer.com/10.1007/978-3-319-53457-2 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
998			_b02/2018 _dz _e- _zSI