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007			cr |n|||||||||
008			170522s2017 sz ob 001 0 eng d
020			_a3319537741 _q(electronic bk.)
020			_a9783319537740 _q(electronic bk.)
020			_z3319537733
020			_z9783319537733
040			_aYDX _cYDX _dN$T _dEBLCP _dGW5XE _dN$T _dYDX _dOCLCO _dAZU _dUPM _dOCLCO _dCOO _dMERER _dOCLCQ _dOCLCO _dJG0 _dOCLCO _dOCLCA _dUAB _dES-MaUEC _bspa
050		4	_aRC846 _b.C455 2017 EB
245	0	0	_aCellular injury in liver diseases _cWen-Xing Ding, Xiao-Ming Yin, editors.
264		1	_aCham _bSpringer _c2017.
300			_a1 recurso en línea
336			_aTexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_atext file _bPDF
490	0		_aCell death in biology and diseases
500			_aSpringerLink
504			_aIncluye referencias bibliográficas e índice
505	0		_aSeries Preface; Preface; Contents; Contributors; Chapter 1: Cell Death in Drug-Induced Liver Injury; 1.1 Introduction; 1.2 Apoptosis in DILI; 1.2.1 FAS; 1.2.2 TRAIL; 1.2.3 Perforin/Granzyme; 1.2.4 TNF; 1.3 JNK in DILI; 1.4 Mitochondria in DILI; 1.5 ER Stress in DILI; 1.6 Regulated Necrosis DILI; 1.7 Autophagy in DILI; 1.8 Cell Death Biomarkers in DILI; 1.8.1 HMGB1; 1.8.2 Keratin 18 (K18); 1.8.3 miRNA; 1.9 Conclusion; References; Chapter 2: ER Stress in Drug-Induced Liver Injury; 2.1 Introduction; 2.2 ER Stress and the Unfolded Protein Response (UPR); 2.3 Drug-Induced Liver Injury (DILI).
505	8		_a2.4 HIV/AIDS and HIV PIs2.5 ER Stress and HIV PI-Induced Hepatotoxicity; 2.5.1 HIV PI-Induced Lipogenesis; 2.5.2 HIV PI-Induced Inflammation; 2.6 Summary; References; Chapter 3: Mechanisms of Acetaminophen-Induced Liver Injury; 3.1 Introduction; 3.2 Metabolism and Initiation of Toxicity; 3.3 The C-JUN-N-Terminal Kinase Pathway in APAP Toxicity; 3.4 The Role of the BCL-2 Protein Family in APAP Hepatotoxicity; 3.5 The Role of Receptor-Interacting Protein Kinase Family Members; 3.6 Oxidative and Nitrosative Stress in APAP Hepatotoxicity.
505	8		_a3.7 Mitochondria-Mediated DNA Fragmentation in APAP Toxicity3.8 Autophagy as an Adaptive Mechanism to APAP-Induced Cellular Stress; 3.9 The Sterile Inflammatory Response During APAP Hepatotoxicity; 3.10 Conclusions; References; Chapter 4: Cell Death and Liver Injuries in Hepatitis C Virus Infection; 4.1 Viral Hepatitis; 4.2 Hepatitis C Virus; 4.2.1 Hepatitis C Virus; 4.2.2 HCV Genome; 4.2.3 HCV Life Cycle; 4.3 Immune Evasion and Chronicity of HCV; 4.4 Cell Death and Liver Injury in Chronic HCV Infection; 4.4.1 Apoptosis: Implications in Inflammation.
505	8		_a4.4.2 Reactive Oxygen Species: Implications in Hepatic Cell Death and Tumorigenesis4.4.3 Autophagy: Implications in Cell Survival and Cancer; 4.4.4 Lipid Metabolism: Implications in Steatosis; 4.5 Conclusion and Future Perspective; References; Chapter 5: Hepatocyte Lethal and Nonlethal Lipotoxic Injury; 5.1 Introduction; 5.2 Lethal Hepatocyte Injury by Lipoapoptosis; 5.3 Lipoapoptosis and Liver Injury; 5.4 Nonlethal Hepatocyte Injury; 5.5 Conclusion; References; Chapter 6: Cell Death in Alcohol-Induced Liver Injury; 6.1 Introduction; 6.2 Alcohol Metabolism and Oxidative Stress.
505	8		_a6.3 Apoptosis, Necrosis, and Necroptosis in ALD6.4 Mechanisms of Alcohol-Induced Apoptosis in Hepatocytes; 6.5 Activation of Mitochondrial (Intrinsic) Apoptotic Pathway by Alcohol; 6.6 Activation of Death Receptor (Extrinsic) Apoptotic Pathway by Alcohol; 6.7 Necrosis and Necroptosis in ALD; 6.8 Other Forms of Regulated Programmed Cell Death in ALD; 6.8.1 Pyroptosis; 6.8.2 Ferroptosis; 6.9 Autophagy and Cell Death in ALD; 6.10 Concluding Remarks and Future Perspective; References; Chapter 7: Bile Acid-Induced Liver Injury in Cholestasis; 7.1 Introduction; 7.2 Bile Acid Biology.
520	3		_aThis comprehensive volume describes drug and virus-mediated hepatocyte injury, alcohol, lipid and bile acid-induced hepatocyte injury in addition to ischemia-reperfusion-mediated liver injury. The chapter authors who discuss these topics are leading experts on cell death in liver diseases. The authors link these different types of liver injury to the commonly associated liver inflammation, fibrosis and tumorigenesis. Other topics explored include the various forms of cell death and cell survival pathways that have been identified in the liver, such as apoptosis, necroptosis, pryoptosis and autophagy. This book, along with its companion volume, Molecules, Systems and Signaling in Hepatic Cell Death, provides a thorough and comprehensive discussion on the topic of cell death and liver disease. Cellular Injury in Liver Diseases is an essential addition to the Cell Death in Biology and Diseases series and will appeal to scientists, clinicians and those doing research for drug discovery.
988			_aEBOOK, EBSPRINGER_2017D
650		7	_2embne _9175413 _aPáncreas _xEnfermedades
650		7	_2embne _aGastroenterología _9141308
700	1		_aDing, Wen-Xing.
700	1		_aYin, Xiao-Ming.
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=http://link.springer.com/10.1007/978-3-319-53774-0 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
998			_b02/2018 _dz _e- _zSI