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008			170520s2017 ja ob 001 0 eng d
020			_a4431565299 _q(electronic bk.)
020			_a9784431565291 _q(electronic bk.)
020			_z4431565272
020			_z9784431565277
040			_aEBLCP _cEBLCP _dGW5XE _dN$T _dYDX _dOCLCQ _dOCLCF _dUAB _dESU _dAZU _dUPM _dIOG _dCOO _dMERER _dOCLCQ _dOHI _dOCLCQ _dU3W _dES-MaUEC _bspa
050		4	_aQP519.9.M64 _bB567 2017 EB
245	0	0	_aBioprobes : _bbiochemical tools for investigating cell function _cHiroyuki Osada, editor.
250			_a2nd ed.
264		1	_aTokyo _bSpringer _c2017.
300			_a1 recurso en línea (387 páginas)
336			_aTexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_atext file _bPDF
500			_aSpringerLink _bSpringer Biomedical and Life Sciences eBooks 2017 English+International
504			_aIncluye referencias bibliográficas e índice
505	0		_aPreface; Contents; Chapter 1: Trends in Bioprobe Research; 1.1 Introduction; 1.2 Screening of New Bioactive Compounds; 1.2.1 Cell-Based Screening; 1.2.2 Target-Based Screening; 1.3 Target Identification of Bioactive Compounds; 1.3.1 Cell Morphology-Based Profiling; 1.3.2 Proteomic Profiling; 1.3.3 Affinity Beads; 1.3.4 DARTS and CESTA; 1.4 Trends and Prospects; References; Chapter 2: Cell Proliferation and Differentiation; 2.1 Cell Growth Signaling Pathway; 2.1.1 Growth Factors and Receptors; 2.1.1.1 EGF Receptors; 2.1.1.2 Ras-MAP Kinase Pathway.
505	8		_a2.1.2 Cytokine Receptors Without Kinase Domains; 2.1.3 Cell Adhesion Receptors; 2.1.4 Dysregulation of Signaling Pathways in Cancer Cells; 2.1.4.1 Bcr-Abl Oncoprotein; 2.1.4.2 Other Abl Fusion Genes in Cancer Cells; 2.1.4.3 Inhibitor of Bcr-Abl Fusion Gene Products; 2.1.4.4 EML4-ALK Oncoprotein; 2.1.4.5 Inhibitor of EML4-ALK Fusion Gene Products; 2.1.4.6 Drug-Resistant Mutation in ALK; 2.1.4.7 Other Fusion Protein Tyrosine Kinases; 2.2 Cell Cycle Regulation; 2.2.1 Cell Cycle Regulators; 2.2.2 Cyclins and CDKs; 2.2.2.1 Cyclin and CDKs; 2.2.2.2 CDKs; 2.2.2.3 Cyclins; 2.2.2.4 CDK Inhibitors.
505	8		_a2.2.3 M-Phase Kinases and Their Inhibitors; 2.2.3.1 Plk1; 2.2.3.2 Plk1 Inhibitors; 2.2.3.3 PBD-Dependent Binding Inhibitors; 2.2.3.4 Aurora Kinases; 2.2.3.5 Aurora Kinase Inhibitors; 2.2.3.6 First-Generation Inhibitors of Aurora Kinases; 2.2.3.7 Pan-Aurora Inhibitors; 2.2.3.8 Aurora A-Specific Inhibitors; 2.2.3.9 Aurora B-Specific Inhibitors; 2.3 Cell Differentiation; 2.3.1 iPS Cells; 2.3.2 iPS Cells Induced by Small-Molecule Compounds; 2.3.3 Medical Purposes; 2.3.4 Cancer Stem Cells; 2.3.5 Small Molecules that Target CSCs; References; Chapter 3: Epigenetics; 3.1 Introduction.
505	8		_a3.2 Histone Acetylation; 3.2.1 Histone Deacetylases; 3.2.2 Histone Deacetylase Inhibitors; 3.2.2.1 Zinc-Dependent Histone Deacetylase Inhibitors; 3.2.2.1.1 Carboxylates; 3.2.2.1.2 Hydroxamic Acids; 3.2.2.1.3 Anilides; 3.2.2.1.4 Cyclic Tetrapeptides; 3.2.2.1.5 Thiols; 3.2.2.1.6 Dietary Inhibitors; 3.2.2.2 Sirtuin Inhibitors; 3.2.2.2.1 NAD Analogs; 3.2.2.2.2 Nicotinamide and Its Analogs; 3.2.2.2.3 beta-Naphthol Analogs; 3.2.2.2.4 Indoles; 3.2.2.2.5 Other Sirtuin Inhibitors; 3.2.3 Histone Acetyltransferases; 3.2.4 Histone Acetyltransferases Inhibitors; 3.2.4.1 Natural Product Inhibitors.
505	8		_a3.2.4.2 Bisubstrate Inhibitors; 3.2.4.3 C646; 3.2.5 Bromodomain and Extraterminal Protein Inhibitors; 3.3 Histone Methylation; 3.3.1 Histone Methyltransferases; 3.3.2 Lys-Specific Histone Methyltransferase Inhibitors; 3.3.2.1 G9a Inhibitors; 3.3.2.2 EZH2 Inhibitors; 3.3.2.3 Dot1L Inhibitors; 3.3.3 Histone Demethylases; 3.3.4 Lysine Demethylases Inhibitors; 3.3.4.1 Lysine Specific Demethylase 1 Inhibitors; 3.3.4.2 Jumonji Domain-Containing Histone Demethylase Inhibitors; 3.4 DNA Methylation; 3.4.1 DNA Methyltransferase Inhibitors; 3.5 Conclusions; References; Chapter 4: Apoptosis and Autophagy; 4.1 Introduction.
520	3		_aThis new edition provides the most advanced research using bioprobes on the chemical control of 1) cell cycle and differentiation, 2) epigenetics, 3) apoptosis and autophagy, and 4) immune response. The "bioprobe", first proposed in the first edition, has become an indispensable tool for chemical biology and has substantially assisted in the investigation of complex biochemical processes of cells. New areas of investigation such as stem cell research, epigenetic research, and autophagy research have rapidly advanced in the past 10 years. Including these new findings, this second edition supplies up-to-date information on the biochemical tools called bioprobes. Data on each bioprobe, such as chemical structure, origin, function, and references, are presented as one item in this volume. Readers will easily find useful information and will be able to determine the appropriate bioprobes to investigate cell functions. The information on bioprobes and their use in research makes this book a valuable source for researchers in diverse fields. Not only scientists in academia but also in the pharmaceutical industries will discover the most important information about small molecules useful for drug discovery.
650		7	_aCitología _xMethodology. _2embne _0(OCoLC)fst00886294 _0 _9139477
700	1		_aOsada, H. _q(Hiroyuki), _d1954-
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=http://link.springer.com/10.1007/978-4-431-56529-1 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
988			_aEBOOK, asignarmaterias, EBSPRINGER_2017D
998			_b02/2018 _dz _e- _zSI
999			_c96027 _d96027 _x1