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020 _a9402410880
_q(electronic bk.)
020 _a9789402410884
_q(electronic bk.)
020 _z9402410864
_q(hardcover ;
_qalk. paper)
020 _z9789402410860
_q(hardcover ;
_qalk. paper)
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050 4 _aRC346
_b.T736 2017 EB
245 0 0 _aTransient receptor potential canonical channels and brain diseases
_cYizheng Wang, editor.
246 3 _aTRPC channels and brain diseases
264 1 _aDordrecht, the Netherlands
_bSpringer
_c[2017]
264 4 _c2017
300 _a1 recurso en línea (viii, 165 páginas)
_bilustraciones (algunas a color)
336 _astill image
_bsti
_2rdacontent
336 _aTexto
_btxt
_2rdacontent
337 _aelectrónico
_bc
_2rdamedia
338 _arecurso electrónico
_bcr
_2rdacarrier
347 _atext file
_bPDF
490 0 _aAdvances in experimental medicine and biology
_x2214-8019
_vvolume 976
500 _aSpringerLink
504 _aIncluye referencias bibliográficas
505 0 _aTRP channel classification / Hongyu Li -- TRPC channel structure and properties / Shengjie Feng -- TRPC channel downstream signaling cascades / Zhuohao He -- TRPC channels in health and disease / Yilin Tai, Shenglian Yang, Yong Liu, Wei Shao -- TRPC channels and programmed cell death / Jian Zhou, Yichang Jia -- TRPC channels and stroke / Junbo Huang -- TRPC channels and Alzheimer's disease / Rui Lu, Qian He, Junfeng Wang -- TRPC channels and Parkinson's disease / Pramod Sukumaran, Yuyang Sun, Anne Schaar, Senthil Selvaraj, Brij B. Singh -- TRPC channels and neuron development, plasticity, and activities / Yilin Tai, Yichang Jia -- TRPC channels and brain inflammation / Yoshito Mizoguchi, Akira Monji -- TRPC channels and epilepsy / Fang Zheng -- TRPC channels and mental disorders / Karina Griesi-Oliveira, Angela May Suzuki, Alysson Renato Muotri -- TRPC channels and cell proliferation / Cheng Zhan, Yu Shi -- TRPC channels and glioma / Shanshan Li, Xia Ding.
520 3 _a"This book discusses the latest findings on the physiological and pathological functions of transient receptor potential canonical/classical (TRPC) proteins in the brain. In addition to reviewing the functions of TRPCs in brain development and neuron transmission, it mainly covers the potential roles of TRPCs in brain disorders. TRPC proteins belong to the TRP channel superfamily, which has around 30 members. Just like TRP channels, TRPCs are non-selectively permeable to cations, with a selectivity of calcium over sodium that varies among different members. The TRPC subfamily consists of six members, grouped on the basis of the similarities in gene sequence and protein structure in mammalians. What sets TRPCs apart from other subfamilies in TRPs is that their activation, stimulated by a membrane receptor-phospholipid C (PLC) cascade, contributes to the slow and sustained elevation of intracellular free calcium. Calcium ions, one of the most important types of second messengers, mediate a variety of physiological functions in the brain, including progenitor cell proliferation, dendritic formation, synaptic transmission and neuronal survival. All TRPCs except TRPC7 have been found in various regions of the brain, including the cerebrum, cerebellum, forebrain and hippocampus. This book provides students and investigators with comprehensive information on the regulation, function and potential of TRPCs and brain diseases in order to attract more attention to this field"--Publisher's description.
988 _aEBOOK, asignarmaterias, EBSPRINGER_2017D
650 7 _aCerebro
_xDiseases.
_2embne
_0(OCoLC)fst00837607
_0
_9139532
700 1 _aWang, Yizheng
_c(Neuroscientist),
_eeditor literario
856 4 0 _uhttps://go.openathens.net/redirector/universidadeuropea.es?url=http://link.springer.com/10.1007/978-94-024-1088-4
_zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942 _2lcc
_cLE
998 _b02/2018
_dz
_e-
_zSI