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_aQP551 _b.P768 2017 EB |
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| 245 | 0 | 0 |
_aProtein reviews. _nVolume 17 _cM. Zouhair Atassi, editor. |
| 264 | 1 |
_aSingapore _bSpringer _c2017. |
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| 300 |
_a1 recurso en línea (vii, 163 páginas) _bilustraciones (algunas a color) |
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| 336 |
_aTexto _btxt _2rdacontent |
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_aelectrónico _bc _2rdamedia |
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_arecurso electrónico _bcr _2rdacarrier |
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_atext file _bPDF |
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_aAdvances in experimental medicine and biology _x0065-2598 _vvolume 925 |
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| 490 | 0 |
_aProtein reviews _vvolume 17 |
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| 500 | _aIncluye índice | ||
| 500 |
_aSpringerLink _bSpringer Biomedical and Life Sciences eBooks 2017 English+International |
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| 505 | 0 | _aPreface; Contents; Aggregation of FET Proteins as a Pathological Change in Amyotrophic Lateral Sclerosis; 1 Introduction; 2 Structure and Physiological Functions of FET Proteins; 3 Pathological Inclusions Containing FET Proteins in ALS Cases; 4 In vitro Aggregation of Recombinant FET Proteins; 5 Concluding Remarks; References; Structural Changes Fundamental to Gating of the Cystic Fibrosis Transmembrane Conductance Regulator Anion Channel Pore; 1 Introduction: Cystic Fibrosis and CFTR; 2 Understanding the Transport Mechanism in CFTR -- A Channel Derived from a Pump. | |
| 505 | 8 | _a1 ESRP1 and ESRP2: Splicing Regulatory Proteins Specifically Expressed in Epithelial Cells2 ESRP Expression Is Upregulated in Cancer Cells; 3 ESRPs Negatively Regulate Cell Motility Through Multiple Mechanisms; 4 Dual Roles of ESRPs on Cancer Progression; 5 Possible Functional Differences Between ESRP1 and ESRP2; 6 Concluding Remarks; References; Controlling Autolysis During Flagella Insertion in Gram-Negative Bacteria; 1 Introduction; 2 Bacterial Flagellum Biosynthesis; 3 Peptidoglycan Degrading Enzymes; 3.1 Role in Flagella Assembly; 3.2 beta-N-Acetylglucosaminidases; 3.2.1 Families. | |
| 505 | 8 | _a3 The Structure and Function of the CFTR Anion Channel4 CFTR Channel Gating; 5 Inferring the Structural Rearrangements During Gating; 5.1 Global Structure of the Pore; 5.2 Location of the Channel Gate(s); 5.3 What Kinds of Movements Do the MSDs Undergo During Gating?; 5.4 Effect of Mutations on Channel Gating; 6 How Can the Conformation of the Channel Pore Be Manipulated to Control CFTR Activity?; 7 Conclusions and Future Perspectives; References; Dual Roles for Epithelial Splicing Regulatory Proteins 1 (ESRP1) and 2 (ESRP2) in Cancer Progression. | |
| 505 | 8 | _a3.2.2 Mechanism of Action3.3 Lytic Transglycosylases; 3.3.1 Families; 3.3.2 Mechanism of Action; 4 Modulation of Flagella-Specific Autolysins; 4.1 Control of Autolysins at the Enzyme Level; 4.2 Control and Modulation of Flagella-Specific Autolytic Activity; 5 Concluding Remarks; References; Regulation of Skeletal Muscle Myoblast Differentiation and Proliferation by Pannexins; 1 Pannexins; 2 Pannexin Expression in Skeletal Muscle; 3 Post-translational Modifications of Panx1 and Panx3; 3.1 Glycosylation; 3.2 Phosphorylation; 3.3 Caspase Cleavage; 3.4 S-Nitrosylation. | |
| 505 | 8 | _a4 Skeletal Muscle Myogenesis and Regeneration4.1 Panx1 Channels Mediate the Acquisition of Myogenic Commitment; 4.2 Panx1 Channels Promote Skeletal Muscle Myoblast Differentiation and Fusion; 4.3 Panx3 Channels Regulate the Proliferation, Differentiation, and Fusion of Skeletal Muscle Myoblasts; 5 Pannexins in Skeletal Muscle Health and Disease; 6 Concluding Remarks; References; Hyaluronidase and Chondroitinase; 1 Glycosaminoglycans; 2 CS/DS and HA-Degrading Enzymes; 2.1 Hyaluronidases (HAases); 2.1.1 Endo-beta-N-Acetylhexosaminidase; 2.1.2 Endo-beta-D-Glucuronidase; 2.1.3 HA Lyase. | |
| 520 | 3 | _aThe aim of the Protein Reviews is to serve as a publication vehicle for review articles that focus on crucial current vigorous aspects of protein structure, function, evolution and genetics. Volume 17 of Protein Reviews is the beginning of a new publication format. The volumes will appear online before they are published in a printed book. Articles will be selected according to their importance to the understanding of biological systems, their relevance to the unravelling of issues associated with health and disease or their impact on scientific or technological advances and developments. The chapters in this volume are authored by experts in the field. They deal with aspects of structure and biological activity of selected proteins. Specific chapters deal with the aggregation of FET proteins (FUS, EWSR1, TAF15) as a pathological change in amyotrophic lateral sclerosis, structural changes fundamental to gating of the cystic fibrosis transmembrane conductance regulator anion channel pore, the dual roles for epithelial splicing regulatory proteins 1 (ESRP1) and 2 (ESRP2) in cancer progression, controlling autolysis during flagella insertion in Gram-negative bacteria, the regulation of skeletal muscle myoblast differentiation and the proliferation by pannexins, hyaluronidase and chondroitinase, factors that control mitotic spindle elongation, how secreted phospholipase A2 type IIA (sPLA2-IIA) activates integrins in an allosteric manner, the simple and unique allosteric machinery of Thermus caldophilus lactate dehydrogenase, and the reduction of chemically stable multibonds: Nitrogenase-like biosynthesis of tetrapyrroles. This volume is intended for research scientists, clinicians, physicians, and graduate students in fields of biochemistry, cell biology, molecular biology microbiology, immunology and genetics. | |
| 650 | 7 |
_aProteínas _2embne _0(OCoLC)fst01079711 _0 _9139861 |
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| 700 | 1 |
_aAtassi, M. Zouhair, _eeditor literario |
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| 856 | 4 | 0 |
_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=http://link.springer.com/10.1007/978-981-10-3710-8 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid) |
| 988 | _aEBOOK, asignarmaterias, EBSPRINGER_2017D | ||
| 998 |
_b02/2018 _dz _e- _zSI |
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