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001			95980
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007			cr |n|||||||||
008			170512s2017 sz o 001 0 eng d
020			_a3319458337 _q(electronic bk.)
020			_a9783319458335 _q(electronic bk.)
020			_z3319458310
020			_z9783319458311
040			_aYDX _cYDX _dN$T _dEBLCP _dN$T _dGW5XE _dIDB _dUAB _dESU _dAZU _dUPM _dIOG _dCOO _dMERER _dOCLCQ _dOCLCF _dVT2 _dU3W _dES-MaUEC _bspa
050		4	_aQH581.2 _bM634 2017 EB
245	0	0	_aModeling cellular systems _cFrederik Graw, Franziska Matthäus, Jürgen Pahle, editors.
264		1	_aCham _bSpringer _c2017.
300			_a1 recurso en línea
336			_aTexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_atext file _bPDF
490	0		_aContributions in mathematical and computational sciences _vvolume 11
500			_aIncluye índice de autor
500			_aSpringerLink _bSpringer Engineering eBooks 2017 English+International
505	0		_aPreface; Organisation; Programme Chairs; Contents; 1 Spatiotemporal Modeling of Membrane Receptors; 1 Introduction; 1.1 Background: Chemical Reaction Networks, ODE Simulations; 2 Reactions (Stochastic); 2.1 Dealing with the Molecular Nature of Chemical Reactions; 2.2 Stochastic Simulation Algorithm; 3 Diffusion; 3.1 Diffusion Basics; 3.2 Brownian or Not Brownian?; 3.3 Brownian Motion Based Simulations; 3.4 Anomalous Diffusion/Barriers to Movement; 4 Reaction -- Diffusion Systems; 4.1 First-Order Reactions and Diffusion; 4.2 Second-Order Reactions.
505	8		_a3.1 Modeling Mitochondria as Obstacles for Diffusion of Calcium IonsReferences; 6 Dynamical Features of the MAP Kinase Cascade; 1 Introduction; 2 The Simple Futile Cycle; 3 The Dual Futile Cycle; 4 The MAPK Cascade; 5 Embedding the Cascade in Feedback Loops; 6 Alternative Phosphorylation Mechanisms; 7 Summary and Outlook; References; 7 Numerical Treatment of the Filament-Based Lamellipodium Model (FBLM); 1 Introduction; 2 Mathematical Modeling; 3 Numerical Method; 3.1 Reparametrization; 3.2 The Finite Element Formulation; 3.3 Time Discretization -- Implementation Issues.
505	8		_a3.1 Time to Reach a Threshold Number of Bound Complexes on the Cell Surface3.2 Number of Receptors Synthesised During the Time to Reach a Threshold Number of Bound Complexes on the Cell Surface; 4 Numerical Results; 5 Discussion; References; 5 Understanding the Role of Mitochondria Distribution in Calcium Dynamics and Secretion in Bovine Chromaffin Cells; 1 Introduction; 2 Experimental Results; 2.1 Experimental Materials and Methods; 2.2 Mitochondria Distribution in Bovine Chromaffin Cells in Culture; 3 Theoretical Model.
505	8		_a4.3 Smoluchowski Model -- Binding Radius Approach to Bimolecular Reactions5 Conclusion; References; 2 Distribution Approximations for the Chemical Master Equation: Comparison of the Method of Moments and the System Size Expansion; 1 Introduction; 2 Stochastic Chemical Kinetics; 3 Method of Moments; 3.1 Equations for Conditional Moments; 3.2 Maximum Entropy Distribution Reconstruction; 4 System Size Expansion of the Probability Distribution; 5 Results; 5.1 Example 1: Bursty Protein Production; 5.2 Example 2: Cooperative Self-Activation of Gene Expression; 5.3 Comparison of Numerical Results.
505	8		_a6 DiscussionReferences; 3 Sampling from T Cell Receptor Repertoires; 1 Introduction; 1.1 Sampling from a Repertoire; 2 Results; 2.1 The Mean Number of Repeats; 2.2 Number of Draws to Find the First Repeat; 2.3 Poisson Distribution of Number of Repeats in a Sample; 2.4 Estimating the Size of the Repertoire from One Repeat; 2.5 The Observed Distribution of Clonal Sizes; 2.6 Expansion of a Fraction of the Repertoire; 3 Discussion; References; 4 IL-2 Stimulation of Regulatory T Cells: A Stochastic and Algorithmic Approach; 1 Introduction; 2 Stochastic Model; 3 Stochastic Descriptors.
520	3		_aThis contributed volume comprises research articles and reviews on topics connected to the mathematical modeling of cellular systems. These contributions cover signaling pathways, stochastic effects, cell motility and mechanics, pattern formation processes, as well as multi-scale approaches. All authors attended the workshop on "Modeling Cellular Systems" which took place in Heidelberg in October 2014. The target audience primarily comprises researchers and experts in the field, but the book may also be beneficial for graduate students.
650		7	_aBiomatemáticas _2embne _0(OCoLC)fst00832555 _0 _9145951
700	1		_aGraw, Frederik.
700	1		_aMatthäus, Franziska.
700	1		_aPahle, Jürgen.
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=http://link.springer.com/10.1007/978-3-319-45833-5 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
988			_aEBOOK, asignarmaterias, EBSPRINGER_2017D
998			_b02/2018 _dz _e- _zSI
999			_c95980 _d95980 _x1