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020 _a3319484273
_q(electronic bk.)
020 _a9783319484273
_q(electronic bk.)
020 _z3319484257
_q(print)
020 _z9783319484259
_q(print)
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050 4 _aQP251
_b2017 EB
245 0 0 _aOxidative stress in human reproduction :
_bshedding light on a complicated phenomenon
_cAshok Agarwal, Rakesh Sharma, Sajal Gupta, Avi Harlev, Gulfam Ahmad, Stefan S. du Plessis, Sandro C. Esteves, Siew May Wang, Damayanthi Durairajanayagam, editors.
264 1 _aCham, Switzerland
_bSpringer International Publishing
_c2017
300 _a1 recurso en línea (xiv, 190 páginas)
_bilustraciones (algunas a color)
336 _aTexto
_btxt
_2rdacontent
337 _aelectrónico
_bc
_2rdamedia
338 _arecurso electrónico
_bcr
_2rdacarrier
347 _atext file
_bPDF
504 _aIncluye referencias bibliográficas
505 0 _aForeword; Reference ; Contents; About the Editors; Contributors; Chapter 1: Overview and Sources of Reactive Oxygen Species (ROS) in the Reproductive System; 1.1 Introduction; 1.1.1 Free Radicals; 1.1.1.1 Superoxide Anion (O2−); 1.1.1.2 Hydroxyl Radical (OH); 1.1.2 Oxidation-Reduction (Redox) Reactions; 1.1.2.1 Haber-Weiss Reaction; 1.1.2.2 Electron Transport Chain (ETC); 1.1.3 Reactive Oxygen Species (ROS); 1.1.3.1 Physiological Roles; 1.1.4 Reactive Nitrogen Species (RNS); 1.1.4.1 Physiological Roles; 1.1.5 Sources of ROS in Male Reproductive System; 1.1.5.1 Generation of ROS
505 8 _a2.1 Introduction2.1.1 Types of Semen Sample Used to Detect ROS; 2.1.2 Measurement of ROS; 2.1.2.1 Nitroblue Tetrazolium Test; 2.1.2.2 Chemiluminescence Assay; 2.1.3 Measurement of DNA Fragmentation; 2.1.3.1 Sperm Chromatin Structure Assay (SCSA); 2.1.3.2 Terminal deoxynucleotidyl Transferees dUTP Nick End Labeling (TUNEL) Assay; 2.1.3.3 Epifluorescence Using Acridine Orange Dye; 2.1.3.4 Comet Assay; 2.1.3.5 Sperm Chromatin Dispersion (SCD) Assay; 2.1.4 Other Methods for Measuring ROS; 2.1.4.1 Measurement of Total Antioxidant Capacity; Colorimetric Analysis; Oxygen Radical Absorbance
505 8 _a3.1 Introduction3.1.1 Physiological Roles of ROS in Male Reproductive System; 3.1.1.1 Spermatogenesis and Sperm Maturation; 3.1.1.2 Sperm Capacitation; 3.1.1.3 Acrosome Reaction; 3.1.1.4 Sperm-oocyte Fusion; 3.2 Conclusion; 3.2.1 Physiological Roles of ROS in the Female Reproductive System; 3.2.1.1 Follicular Development; 3.2.1.2 Ovarian Steroidogenesis; 3.2.1.3 Ovulation; 3.2.1.4 Corpus Luteum; Formation; Luteolysis; 3.2.1.5 Maintenance of Pregnancy; 3.2.1.6 Parturition; 3.3 Conclusion; References; Chapter 4: Negative Effects of Oxidative Stress (OS) on Reproductive System at Cellular Level
505 8 _aFerric Reducing Ability Assay2.1.4.2 ROS-TAC Score; 2.1.4.3 Measurement of Redox Potential; 2.1.5 Measurement of Lipid Peroxidation; 2.1.5.1 HNE-His Adduct ELISA/HNE Adduct Competitive ELISA; 2.1.5.2 Isprostane (IsoP) Method; 2.1.5.3 TBARS Assay; 2.1.6 Measurement of ROS-Induced Post-Translational Modifications; 2.1.7 Measurement of ROS-Induced Protein Alterations-Proteomic Analysis; 2.1.7.1 Validation of Proteins of Interest; Western Blot Analysis; Immunochemistry; ELISA; 2.2 Conclusion; References; Chapter 3: Physiological Roles of Reactive Oxygen Species (ROS) in the Reproductive System
505 8 _aNADPH OxidasesElectron Leakage in the Mitochondria; 1.1.5.2 Sources of ROS in Seminal Plasma; Immature/Abnormal Spermatozoa; Leukocytes; Varicocele; 1.2 Conclusion; 1.2.1 Sources of ROS in Female Reproductive System; 1.2.2 Steroidogenesis and Ovulation; 1.2.3 Graffian Follicle; 1.2.4 Granulosa Cells and Cumulus Mass Cells; 1.2.5 Follicular Fluid; 1.2.6 Fallopian Tube; 1.2.7 Peritoneal Cavity; 1.2.8 Endometrium; 1.3 Conclusion; 1.3.1 Oxidative Stress (OS); References; Chapter 2: Methods to Measure Reactive Oxygen Species (ROS) and Total Antioxidant Capacity (TAC) in the Reproductive System
520 3 _aThis book discusses the role of oxidative stress in the reproductive system. The book reviews endogenous sources, methods of determining its levels in body fluid/tissues, the physiological roles of ROS, as well as its negative effects on the human reproductive processes. Also discussed are multiple extrinsic factors that could induce oxidative stress in the reproductive system. This brief covers various clinical pathologies related to the reproductive system that arise from or produce oxidative stress, both in the male and female. The use of antioxidants as a therapeutic measure to keep ROS levels in check are highlighted, describing the outcome of various clinical studies involving antioxidant supplementation in infertile patients. Infertility is a global disease that affects 15-25% of all couples, and oxidative stress arising from a multitude of sources has been implicated as one of the major contributing factors to the decline in human fertility. As such, this book provides an up-to-date review on the significance of ROS in human reproduction.
650 7 _aOxígeno
_xPhysiological effect.
_2embne
_0(OCoLC)fst00796285
_0
_9146654
700 1 _aAgarwal, Ashok
_c(Physician),
_eeditor literario
_985093
700 1 _aAhmad, Gulfam,
_eeditor literario
700 1 _aDu Plessis, Stefan S.,
_eeditor literario
_986864
700 1 _aDurairajanayagam, Damayanthi
_eeditor literario
_986862
700 1 _aEsteves, Sandro,
_eeditor literario
700 1 _aGupta, Sajal,
_eeditor literario
_995343
700 1 _aHarlev, Avi,
_eeditor literario
_995344
700 1 _aSharma, Rakesh,
_eeditor literario
_998052
700 1 _aWang, Siew May,
_eeditor literario
856 4 0 _uhttps://go.openathens.net/redirector/universidadeuropea.es?url=http://link.springer.com/10.1007/978-3-319-48427-3
_zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
988 _aSpringer_Medicine_2017
998 _b02/2018
_dz
_e-
_zSI
999 _c95959
_d95959
_x1