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001			95945
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007			cr cnu|||unuuu
008			170508s2017 gw a o 001 0 eng d
020			_a3662532735 _q(electronic bk.)
020			_a9783662532737 _q(electronic bk.)
020			_z3662532719
020			_z9783662532713 _q(print)
040			_aN$T _cN$T _dGW5XE _dEBLCP _dN$T _dYDX _dOCLCF _dOCLCO _dUAB _dESU _dAZU _dUPM _dIOG _dOCLCO _dCOO _dMERER _dOCLCO _dOCLCQ _dOCLCO _dU3W _dOCLCO _dOCLCA _dES-MaUEC _bspa
050		4	_aRL801 _b2017 EB
245	0	0	_aPercutaneous penetration enhancers physical methods in penetration enhancement _cNina Dragicevic, Howard I. Maibach, editors.
264		1	_aBerlin, Germany _bSpringer International Publishing _c2017
300			_a1 recurso en línea (xvii, 508 páginas) _bilustraciones (algunas a color)
336			_aTexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_atext file _bPDF
505	0		_aPreface; Contents; Contributors; Part I: Sonophoresis in Penetration Enhancement; 1: Sonophoresis: Ultrasound- Mediated Transdermal Drug Delivery; 1.1 Introduction; 1.2 Ultrasound and Sonophoresis; 1.3 Low-Frequency Sonophoresis; 1.4 Low-Frequency Sonophoresis: Choice of Parameters; 1.5 Mechanism of Low-ƯFrequency Sonophoresis; 1.6 Permeation Pathways of Low-Frequency Sonophoresis; 1.7 Macromolecular Delivery; 1.7.1 Peptides and Proteins; 1.7.2 Low-Molecular-Weight Heparin; 1.7.3 Oligonucleotides; 1.7.4 Vaccines; 1.8 Clinical Studies.
505	8		_a1.9 Transdermal Extraction of Analytes Using Sonophoresis1.10 Safety of Low-Frequency Ultrasound; References; 2: The Mechanism of Sonophoresis and the Penetration Pathways; 2.1 Introduction; 2.2 Mechanism of Sonophoresis; 2.2.1 Thermal Effect; 2.2.2 Cavitation Effect; 2.2.2.1 Stable Cavitation; 2.2.2.2 Inertial Cavitation; 2.3 Penetration Pathways Induced by Sonophoresis; 2.3.1 Pathways Through Hair Follicles; 2.3.2 Penetration Pathways Through the Stratum Corneum; 2.3.3 Transcellular Pathways.
505	8		_a2.4 Synergistic Effect of Low-ƯFrequency Sonophoresis and Other Enhancers for Transdermal Drug Delivery2.5 Factors Affecting Drug Delivery by Low-Frequency Sonophoresis; 2.6 Therapeutic Application of Sonophoresis; 2.6.1 Noninvasive Transdermal Monitoring; 2.6.2 Sonophoresis in Transcutaneous Immunization and Gene Therapy; 2.6.3 Safety Issues and Commercial Devices; References; 3: Therapeutic Applications of Sonophoresis and Sonophoretic Devices; 3.1 Introduction; 3.2 Ultrasound; 3.3 Advantages and Drawbacks of Sonophoresis; 3.4 Therapeutic Applications of ULS; 3.4.1 Drug Release.
505	8		_a3.4.1.1 Topical/Transdermal Drug Release3.4.1.2 Ocular Drug Delivery; 3.4.1.3 Nail Delivery; 3.4.2 Gene Delivery; 3.5 Sonophoretic Devices; 3.5.1 Sonophoretic Systems Available in the Market; 3.5.1.1 Patch-Cap, U-Strip, U-Wand, and A-Wand Systems; Sonoderm Technology; SonoLysis; SonoPrep® Skin Permeation System; 3.5.2 Combination of Sonophoretic Systems with Other Enhancing Technologies; 3.5.2.1 ULS and Chemical Penetration Enhancers; 3.5.2.2 ULS and Iontophoresis; 3.5.2.3 ULS and Microneedles; 3.5.2.4 ULS and Nanocarriers; References.
505	8		_aPart II: Iontophoresis in Penetration Enhancement4: Iontophoresis: Basic Principles; 4.1 Introduction; 4.2 Chronology: From First Reports to Recent Discoveries; 4.3 Application Sites Other than the Skin; References; 5: Iontophoretic Transport Mechanisms and Factors Affecting Electrically Assisted Delivery; 5.1 Introduction; 5.2 Factors Influencing Electrically Assisted Drug Delivery; 5.2.1 Current Density; 5.2.2 Formulation; 5.2.2.1 Drug Concentration; 5.2.2.2 pH; 5.2.3 Delivery System; References; 6: Iontophoresis for Therapeutic Drug Delivery and Non-invasive Sampling Applications.
520	3		_aPercutaneous Penetration Enhancers in a mini-series format comprising five volumes, represents the most comprehensive reference on enhancement methods - both well established and recently introduced - in the field of dermal/transdermal drug delivery. In detail the broad range of both chemical and physical methods used to enhance the skin delivery of drugs is described. All aspects of drug delivery and measurement of penetration are covered, and the latest findings are provided on skin structure and function, mathematics in skin permeation, and modern analytical techniques adapted to assess and measure penetration. In offering a detailed description of the methods currently in use for penetration enhancement, this book will be of value for researchers, pharmaceutical scientists, practitioners, and also students.
650		7	_aDermatología _xFórmulas y recetas _2embne _0(OCoLC)fst01766346 _0 _9367961
700	1		_aDragicevic, Nina, _eeditor literario _995560
700	1		_aMaibach, Howard I., _eeditor literario _937880
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=http://link.springer.com/10.1007/978-3-662-53273-7 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
988			_aSpringer_Medicine_2017
998			_b02/2018 _dz _e- _zSI
999			_c95945 _d95945 _x1