| 000 | 05271cam a2200445Ii 4500 | ||
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| 988 | _aSpringer_Medicine_2017 | ||
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_c95878 _d95878 _x1 |
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| 001 | 95878 | ||
| 003 | ES-MaUEC | ||
| 005 | 20230102112726.0 | ||
| 006 | m o d | ||
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| 008 | 170426s2017 sz a o 001 0 eng d | ||
| 020 |
_a3319397087 _q(electronic bk.) |
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| 020 |
_a9783319397085 _q(electronic bk.) |
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| 020 | _z3319397079 | ||
| 020 |
_z9783319397078 _q(print) |
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| 050 | 4 |
_aRJ416.L4 _b2017 EB |
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| 245 | 0 | 0 |
_aChildhood acute lymphoblastic leukemia _cAjay Vora, editor. |
| 264 | 1 |
_aCham, Switzerland _bSpringer _c2017. |
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| 300 |
_a1 recurso en línea (ix, 342 páginas) _bilustraciones (algunas a color) |
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| 336 |
_aTexto _btxt _2rdacontent |
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| 337 |
_aelectrónico _bc _2rdamedia |
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| 338 |
_arecurso electrónico _bcr _2rdacarrier |
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| 347 |
_atext file _bPDF _2rda |
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| 500 | _aIncluye índice | ||
| 500 | _aSpringerLink | ||
| 505 | 0 | _aContributors; Chapter 1: Epidemiology and Etiology of Childhood ALL; 1.1 Introduction; 1.2 General Epidemiology; 1.3 Natural History; 1.4 Environmental Risk Factors; 1.4.1 Infectious Disease and Immune Stimulation; 1.4.2 Other Risk Factors; 1.5 Heritability of ALL; 1.6 High-Penetrance Genetic Predisposition; 1.6.1 Syndromes Where ALL Is a Dominant Cancer Phenotype; 1.6.2 Syndromes Where ALL Is Part of a Mixed Cancer Phenotype; 1.7 Low-Penetrance Genetic Predisposition; 1.8 Future Directions; References; Chapter 2: Clinical Presentation and Prognostic Factors. | |
| 505 | 8 | _a2.1 Clinical Presentation2.1.1 Introduction; 2.1.2 Symptoms and Signs Related to Bone Marrow Involvement; 2.1.3 Symptoms and Signs Related to Extensive Bulk Disease; 2.1.4 Central Nervous System; 2.1.5 The Eye; 2.1.6 Genitourinary System; 2.1.7 Cardiovascular System; 2.1.8 The Skin; 2.1.9 Head and Neck; 2.1.10 Gastrointestinal System; 2.1.11 Hypercalcaemia; 2.1.12 Haemophagocytic Lymphohistiocytosis (HLH); 2.1.13 Aplastic Presentation; 2.1.14 Rare Presentations; 2.1.15 Asymptomatic Pancytopenia; 2.1.16 The Diagnostic Interval and Pathway; 2.1.17 Differential Diagnosis; 2.2 Laboratory Features. | |
| 505 | 8 | _a2.2.1 Haematology2.2.2 Biochemistry; 2.2.3 Bone Marrow Aspirate; 2.2.4 Lumbar Puncture; 2.3 Diagnostic Workup; 2.4 Prognostic Factors; 2.5 Individual Prognostic Factors; 2.5.1 Age; 2.5.2 White Cell Count; 2.5.3 NCI Risk Score; 2.5.4 Gender; 2.5.5 CNS Disease; 2.5.6 Disease Bulk; 2.5.7 Immunophenotype; 2.5.8 Genetics; 2.5.9 Response to Treatment; References; Chapter 3: Diagnostic Flow Cytometry and Immunophenotypic Classification; 3.1 Introduction; 3.2 Immunophenotype of T-Lymphoblastic Leukemia/Lymphoma; 3.3 Early T-Cell Precursor ALL; 3.4 Immunophenotype of B-Lymphoblastic Leukemia/Lymphoma. | |
| 505 | 8 | _a3.5 Acute Leukaemia of Ambiguous Lineage3.6 Antigen Expression: Correlation to Prognosis and Cytogenetics; 3.7 Extended Leukaemia Immunophenotyping; 3.8 Conclusions and Perspective; References; Chapter 4: Cytogenetics and Molecular Genetics; 4.1 Introduction; 4.2 Abnormality Detection Methodologies; 4.3 Chromosomal Abnormalities in BCP-ALL; 4.3.1 Favourable Risk Abnormalities; 4.3.1.1 High Hyperdiploidy; 4.3.1.2 t(12; 21)(p13; q22)/ETV6-RUNX1; 4.3.1.3 t(1; 19)(q23; p13)/TCF3-PBX1; 4.3.2 Poor-Risk Chromosomal Abnormalities; 4.3.2.1 t(9; 22)(q34; q11.1)/BCR-ABL1; 4.3.2.2 t(17; 19)(q22. | |
| 505 | 8 | _aP13)/TCF3-HLF4.3.2.3 11q23/KMT2A Gene Rearrangements; 4.3.2.4 Near-Haploidy and Low Hypodiploidy; 4.3.2.5 Intrachromosomal Amplification of Chromosome 21 (iAMP21); 4.3.3 B-ALL Lacking Sentinel Chromosomal Rearrangements; 4.3.3.1 Ph-Like or BCR-ABL1-Like ALL; 4.3.3.2 CRLF2 Rearrangements and Janus Kinase Mutations in ALL; 4.3.3.3 DUX4 and ERG-Deregulated ALL; 4.3.3.4 Translocations Involving the IGH Locus; 4.3.3.5 PAX5 Rearrangements; MEF2D and ZNF384 Gene Fusions; ETV6-RUNX1-Like; 4.3.4 Secondary Genetic Alterations in BCP-ALL; 4.4 Genetic Rearrangements in T-Lineage ALL. | |
| 520 | 3 | _aThis book provides a comprehensive and up-to-date review of all aspects of childhood Acute Lymphoblastic Leukemia, from basic biology to supportive care. It offers new insights into the genetic pre-disposition to the condition and discusses how response to early therapy and its basic biology are utilized to develop new prognostic stratification systems and target therapy. Readers will learn about current treatment and outcomes, such as immunotherapy and targeted therapy approaches. Supportive care and management of the condition in resource poor countries are also discussed in detail. This is an indispensable guide for research and laboratory scientists, pediatric hematologists as well as specialist nurses involved in the care of childhood leukemia. | |
| 588 | 0 | _aOnline resource; title from PDF title page (SpringerLink, viewed April 27, 2017). | |
| 650 | 7 |
_2embne _aLeucemia _9140673 |
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| 700 | 1 |
_aVora, Ajay, _eeditor literario |
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| 856 | 4 | 0 |
_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=http://link.springer.com/10.1007/978-3-319-39708-5 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid) |
| 942 |
_2lcc _cLE |
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| 998 |
_b02/2018 _dz _e- _zSI |
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