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008			170419s2017 si o 000 0 eng d
020			_a9789811044991 _q(electronic bk.)
020			_a9811044996 _q(electronic bk.)
020			_z9789811044984 _q(print)
020			_z9811044988
040			_aN$T _cN$T _dEBLCP _dN$T _dGW5XE _dOCLCF _dYDX _dUAB _dOCLCO _dESU _dAZU _dUPM _dOCLCO _dIOG _dOCLCO _dCOO _dOTZ _dVT2 _dOCLCQ _dOCLCO _dOCLCA _dU3W _dOCLCO _dES-MaUEC _bspa
050		4	_aQH585.5.F56 _bS564 2017 EB
245	0	0	_aSingle cell analysis : _bcontemporary research and clinical applications _cJ. Paul Robinson, Andrea Cossarizza, editors.
264		1	_aSingapore _bSpringer _c2017.
300			_a1 recurso en línea
336			_aTexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	0		_aSeries in bioengineering
500			_aSpringerLink _bSpringer Engineering eBooks 2017 English+International
505	0		_aPreface; Acknowledgements; Contents; Contributors; 1 Microenvironment Cytometry; Abstract; 1 Microcommunities and Microenvironments; 1.1 Introduction; 1.1.1 Boundaries and Niches; 1.1.2 Tumor Microenvironment [TME]; 2 Plasticity of Cellular Communities; 2.1 Landscapes and Attractor States; 2.2 Cell Transitions and Interactions: The Glycome; 2.3 Cellular Interactions in a Microcommunity: Transitions in NCAM Polysialylation; 3 Chromosomal Instability (CIN) and the Microenvironment; 3.1 Cytometric Analysis of Chromosomal Instability; 3.2 Mitotic Bypass; 3.3 Mitotic Bypass and the p53 Network.
505	8		_a4 Cytomics of Oxidative Stress: Probes and ProblemsAbstract; 1 Introduction to Reactive Oxygen (ROS) and Nitrogen (RNS) Species; 2 The Physiological Side of ROS and NOS; 2.1 Sources of ROS and RNS; 2.2 ROS in Phagocytosis; 2.3 ROS and RNS in Cellular Signaling; 3 Oxidative Stress: Definition, Causes, and Consequences; 3.1 Definition of Oxidative Stress; 3.2 Causes of Oxidative Stress; 3.3 Consequences of Oxidative Stress; 3.3.1 Protein Damage; 3.3.2 Lipid Peroxidation; 3.3.3 Oxidative Lesions to DNA; 4 Strategies and Reagents for Cytomic Analysis of Oxidative Stress.
505	8		_a4 In Vitro Microenvironment Models and Hollow Fiber Technology4.1 3D Models: Multicellular Tumor Spheroids; 4.2 Encapsulation Systems; 4.2.1 Microencapsulation and Macroencapsulation; 4.2.2 HF Bioreactor (HFB) Cell-Culture Systems; 4.2.3 HF Microenvironment Control; 4.2.4 HF Implant Assay; 4.2.5 HFA Cytometry; 5 Microenvironment and Hypoxia; 5.1 Modeling the Hypoxic Microenvironment; 5.2 Stromal-Tumor Hypoxia; 5.3 Hypoxia Detection; 5.4 Cellular Responses to the Hypoxic Tumor Environment; 6 Targeting Hypoxia; 6.1 The Therapeutic Paradigm; 6.2 Hypoxia-Activated Prodrugs: HAPs.
505	8		_a6.3 Unidirectional HAPs (uHAPs) and Multilevel Targeting7 The Continuing Challenge; Acknowledgements and Declarations; References; 2 Rare Cells: Focus on Detection and Clinical Relevance; Abstract; 1 Introduction; 2 Ag-Specific T Cells; 3 Invariant Natural Killer T (iNKT) Cells; 4 Circulating Endothelial Cells and Their Precursors; 5 Circulating Tumor Cells; 6 Analysis of Rare Events by Flow Cytometry: The First Step; 6.1 Enrichment and Choice of Markers; 6.2 Number of Acquired Events; 6.3 Sample Concentration and Flow Rate; 6.4 Thresholds, Gating, and DUMP Channel; 6.5 Data Analysis.
520	3		_aThis book highlights the current state of the art in single cell analysis, an area that involves many fields of science - from clinical hematology, functional analysis and drug screening, to platelet and microparticle analysis, marine biology and fundamental cancer research. This book brings together an eclectic group of current applications, all of which have a significant impact on our current state of knowledge. The authors of these chapters are all pioneering researchers in the field of single cell analysis. The book will not only appeal to those readers more focused on clinical applications, but also those interested in highly technical aspects of the technologies. All of the technologies identified utilize unique applications of photon detection systems.
650		7	_aCitometría de flujo _2embne _0(OCoLC)fst00927770 _0 _9668358
700	1		_aCossarizza, Andrea, _d1958- _eeditor literario
700	1		_aRobinson, J. Paul, _eeditor literario
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=http://link.springer.com/10.1007/978-981-10-4499-1 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
988			_aEBOOK, asignarmaterias, EBSPRINGER_2017C
998			_b02/2018 _dz _e- _zSI
999			_c95830 _d95830 _x1